Efficacy of different routes of acetaminophen administration for postoperative pain in children: a systematic review and network meta-analysis

CONCLUSION: The available evidence on the effect of the administration route of acetaminophen on postoperative pain in children is very uncertain. The outcomes of postoperative pain control and postoperative vomiting may differ very little between the oral and rectal route. Better designed and executed RCTs are required to address this important clinical question.STUDY REGISTRATION: PROSPERO (CRD42021286495); first submitted 19 November 2021.PMID:38622469 | DOI:10.1007/s12630-024-02760-y

Source: Canadian Journal of Anaesthesia - April 15, 2024 Category: Anesthesiology Authors: Danilo Osorio Diana Maldonado Koen Rijs Caroline van der Marel Markus Klimek Jose A Calvache Source Type: research