Safety of a 90-min duration of intravenous infusion of obinutuzumab in patients with B-cell non-Hodgkin's lymphoma in a tertiary hospital in China: a prospective, open-label, exploratory clinical trial
This study aimed to analyze the safety and applicability of a 90-min duration of infusion (SDI) of obinutuzumab in patients with B-cell non-Hodgkin's lymphoma (NHL) in a tertiary hospital in China. This exploratory clinical trial was performed at Jiangsu Province Hospital. All patients were treated with the standard infusion regimen for the first infusion. If no grade ≥3 infusion-related reactions (IRRs) occurred, the subsequent infusions were given as SDI. The primary endpoint was the incidence of IRR during the standard infusion (3-4 h) and 90-min SDI regimens. This study enrolled 208 patients and all completed cycle 1...
Source: Braz J Med Biol Res - February 15, 2024 Category: Research Authors: Shuangshuang Xing Yiqin Pu Xiaoqian Zhao Yan Hu Feiyan Zhang Zejuan Gu Wei Xu Lei Fan Yi Miao Jianyong Li Source Type: research
Sustainable Beckmann Rearrangement using Bead-Milling Technology: The Route to Paracetamol
ChemSusChem. 2024 Feb 14:e202301921. doi: 10.1002/cssc.202301921. Online ahead of print.ABSTRACTTo address the growing demand for more sustainable and greener chemistry, mechanochemical methodologies are emerging as key players. However, to date there has been little data highlighting the benefits of these rising mechanochemical technologies with regard to process scale-up activities or implementation in commercial production scale. Herein, we report the first application of bead-mill technology (Dyno®-mill) for the sustainable mechanochemical synthesis of Acetaminophen, known under the brand name Paracetamol. Using the B...
Source: ChemSusChem - February 14, 2024 Category: Chemistry Authors: Romain Geib Evelina Colacino Ludovic Gremaud Source Type: research
Inhibitory Effect of Acetaminophen on Ocular Pigmentation and its Relationship with Thyroxine in Zebrafish Embryos
Bull Environ Contam Toxicol. 2024 Feb 14;112(2):39. doi: 10.1007/s00128-024-03867-0.ABSTRACTAcetaminophen (N-acetyl-p-aminophenol; APAP) is one of the most widely used analgesics. To examine the toxicity of APAP, we used zebrafish embryos as model animals to detect the effect of APAP on the thyroid system of zebrafish embryos. The zebrafish embryos were exposed to APAP from 4 h post fertilization (4 hpf) until observation. The experimental results showed that APAP caused pericardial edema and decreased pigmentation in the zebrafish embryos or larvae. The APAP treatment caused a decrease in the expression of tpo and thrβ i...
Source: Bulletin of Environmental Contamination and Toxicology - February 14, 2024 Category: Environmental Health Authors: Huan Wang Guiying Kang Chenglong Ma Hua Lian Kexin Zhao Baoquan Zhao Yuanzhou Feng Wu Dong Source Type: research
CLEC-1 Restrains Acute Inflammatory Response and Recruitment of Neutrophils following Tissue Injury
J Immunol. 2024 Feb 14:ji2300479. doi: 10.4049/jimmunol.2300479. Online ahead of print.ABSTRACTThe inflammatory response is a key mechanism for the elimination of injurious agents but must be tightly controlled to prevent additional tissue damage and progression to persistent inflammation. C-type lectin receptors expressed mostly by myeloid cells play a crucial role in the regulation of inflammation by recognizing molecular patterns released by injured tissues. We recently showed that the C-type lectin receptor CLEC-1 is able to recognize necrotic cells. However, its role in the acute inflammatory response following tissue...
Source: Journal of Immunology - February 14, 2024 Category: Allergy & Immunology Authors: Camille Ligeron Javier Saenz Berangere Evrard Marion Drouin Emmanuel Merieau Caroline Mary Kevin Biteau Emmanuelle Wilhelm C écile Batty Vanessa Gauttier Irene Baccelli Nicolas Poirier Elise Chiffoleau Source Type: research
Inhibitory Effect of Acetaminophen on Ocular Pigmentation and its Relationship with Thyroxine in Zebrafish Embryos
Bull Environ Contam Toxicol. 2024 Feb 14;112(2):39. doi: 10.1007/s00128-024-03867-0.ABSTRACTAcetaminophen (N-acetyl-p-aminophenol; APAP) is one of the most widely used analgesics. To examine the toxicity of APAP, we used zebrafish embryos as model animals to detect the effect of APAP on the thyroid system of zebrafish embryos. The zebrafish embryos were exposed to APAP from 4 h post fertilization (4 hpf) until observation. The experimental results showed that APAP caused pericardial edema and decreased pigmentation in the zebrafish embryos or larvae. The APAP treatment caused a decrease in the expression of tpo and thrβ i...
Source: Bulletin of Environmental Contamination and Toxicology - February 14, 2024 Category: Environmental Health Authors: Huan Wang Guiying Kang Chenglong Ma Hua Lian Kexin Zhao Baoquan Zhao Yuanzhou Feng Wu Dong Source Type: research
Inhibitory Effect of Acetaminophen on Ocular Pigmentation and its Relationship with Thyroxine in Zebrafish Embryos
Bull Environ Contam Toxicol. 2024 Feb 14;112(2):39. doi: 10.1007/s00128-024-03867-0.ABSTRACTAcetaminophen (N-acetyl-p-aminophenol; APAP) is one of the most widely used analgesics. To examine the toxicity of APAP, we used zebrafish embryos as model animals to detect the effect of APAP on the thyroid system of zebrafish embryos. The zebrafish embryos were exposed to APAP from 4 h post fertilization (4 hpf) until observation. The experimental results showed that APAP caused pericardial edema and decreased pigmentation in the zebrafish embryos or larvae. The APAP treatment caused a decrease in the expression of tpo and thrβ i...
Source: Bulletin of Environmental Contamination and Toxicology - February 14, 2024 Category: Environmental Health Authors: Huan Wang Guiying Kang Chenglong Ma Hua Lian Kexin Zhao Baoquan Zhao Yuanzhou Feng Wu Dong Source Type: research
Inhibitory Effect of Acetaminophen on Ocular Pigmentation and its Relationship with Thyroxine in Zebrafish Embryos
Bull Environ Contam Toxicol. 2024 Feb 14;112(2):39. doi: 10.1007/s00128-024-03867-0.ABSTRACTAcetaminophen (N-acetyl-p-aminophenol; APAP) is one of the most widely used analgesics. To examine the toxicity of APAP, we used zebrafish embryos as model animals to detect the effect of APAP on the thyroid system of zebrafish embryos. The zebrafish embryos were exposed to APAP from 4 h post fertilization (4 hpf) until observation. The experimental results showed that APAP caused pericardial edema and decreased pigmentation in the zebrafish embryos or larvae. The APAP treatment caused a decrease in the expression of tpo and thrβ i...
Source: Bulletin of Environmental Contamination and Toxicology - February 14, 2024 Category: Environmental Health Authors: Huan Wang Guiying Kang Chenglong Ma Hua Lian Kexin Zhao Baoquan Zhao Yuanzhou Feng Wu Dong Source Type: research
Inhibitory Effect of Acetaminophen on Ocular Pigmentation and its Relationship with Thyroxine in Zebrafish Embryos
Bull Environ Contam Toxicol. 2024 Feb 14;112(2):39. doi: 10.1007/s00128-024-03867-0.ABSTRACTAcetaminophen (N-acetyl-p-aminophenol; APAP) is one of the most widely used analgesics. To examine the toxicity of APAP, we used zebrafish embryos as model animals to detect the effect of APAP on the thyroid system of zebrafish embryos. The zebrafish embryos were exposed to APAP from 4 h post fertilization (4 hpf) until observation. The experimental results showed that APAP caused pericardial edema and decreased pigmentation in the zebrafish embryos or larvae. The APAP treatment caused a decrease in the expression of tpo and thrβ i...
Source: Bulletin of Environmental Contamination and Toxicology - February 14, 2024 Category: Environmental Health Authors: Huan Wang Guiying Kang Chenglong Ma Hua Lian Kexin Zhao Baoquan Zhao Yuanzhou Feng Wu Dong Source Type: research
Pain Management for Ambulatory Surgery: Current Controversies and Concerns
AbstractPurpose of ReviewAdequate pain control is essential for ensuring optimal outcomes after ambulatory surgery. However, postoperative pain continues to be inadequately treated. This review presents the available evidence regarding strategies for pain management for ambulatory surgery with the aim of developing an optimal procedure-specific multimodal approach.Recent FindingsOptimal analgesic strategy should include preoperative identification of patients at high risk of postoperative pain, patient education, and an opioid-sparing multimodal analgesic technique using non-opioid analgesics such as acetaminophen and non-...
Source: Current Anesthesiology Reports - February 13, 2024 Category: Anesthesiology Source Type: research
Maternal Administration of Acetaminophen Affects Meiosis Through its Metabolite NAPQI Targeting SIRT7 in Fetal Oocytes
Antioxidants&Redox Signaling, Ahead of Print. (Source: Antioxidants and Redox Signaling)
Source: Antioxidants and Redox Signaling - February 13, 2024 Category: Research Authors: Fangfei Liu Junlin He Xuemei Chen Ronglu Liu Fangfang Li Yanqing Geng Yuhan Dai Yan Zhang Yingxiong Wang Xinyi Mu Source Type: research
Clinically relevant therapeutic approaches against acetaminophen hepatotoxicity and acute liver failure
Biochem Pharmacol. 2024 Feb 10:116056. doi: 10.1016/j.bcp.2024.116056. Online ahead of print.ABSTRACTLiver injury and acute liver failure caused by an acetaminophen (APAP) overdose is a significant clinical problem in western countries. With the introduction of the mouse model of APAP hepatotoxicity in the 1970 s, fundamental mechanisms of cell death were discovered. This included the recognition that part of the APAP dose is metabolized by cytochrome P450 generating a reactive metabolite that is detoxified by glutathione. After the partial depletion of glutathione, the reactive metabolite will covalently bind to sulfhydry...
Source: Biochemical Pharmacology - February 12, 2024 Category: Drugs & Pharmacology Authors: Anup Ramachandran Jephte Y Akakpo Steven C Curry Barry H Rumack Hartmut Jaeschke Source Type: research
Potential of acetaminophen on the sublingual microcirculation and peripheral tissue perfusion of febrile septic patients: prospective observational study
Acetaminophen (ACT) has been studied in septic patients with detectable plasmatic levels of cell-free hemoglobin (Hb), where it demonstrated to inhibit the hemoprotein-mediated lipid peroxidation and oxidative... (Source: Annals of Intensive Care)
Source: Annals of Intensive Care - February 10, 2024 Category: Intensive Care Authors: R. Domizi, E. Damiani, A. Carsetti, L. Graciotti, A. D. Procopio, C. Scorcella, E. Casarotta, P. Giaccaglia, A. Donati and E. Adrario Tags: Research Source Type: research
Comparison of Properties of Acetaminophen Tablets Prepared by Wet Granulation Using Freeze-Dried Versus Phase-Inversion Bacterial Cellulose as Diluent
This study aimed to compare the properties of tablets prepared by the wet granulation method using bacterial cellulose prepared by different methods as a diluent, using acetaminophen as a model drug. BC used as diluents were prepared using two different methods: freeze-drying (BC-FD) and phase-inversion (BC-PI), and their characteristics were analyzed and compared with that of commercial microcrystalline cellulose PH 101 (Comprecel® M101). Acetaminophen tablets were prepared by wet granulation using BC-FD, BC-PI, or Comprecel® M101 as diluents, and their tablet properties were examined. The result showed that the morphol...
Source: AAPS PharmSciTech - February 9, 2024 Category: Drugs & Pharmacology Authors: Sirikanya Kaewpradit Jiraporn Chingunpitak Wannaphorn Samhadthai Thanyanit Suppawattana Chutima Jantarat Source Type: research
Beyond Traditional Pain Relief: A Review of Alternative Analgesics in Myocardial Infarction Patient Management
J Pain Palliat Care Pharmacother. 2024 Feb 8:1-13. doi: 10.1080/15360288.2024.2304008. Online ahead of print.ABSTRACTWhile morphine is the recommended first-line treatment for pain management in patients with acute coronary syndrome, recent studies have raised concerns about its association with adverse outcomes. Morphine has been found to cause delayed antiplatelet effects, decreased ticagrelor absorption, increased platelet reactivity, and compromised efficacy of dual antiplatelet therapy (DAPT). Alternative analgesics, such as lidocaine, fentanyl, and acetaminophen, have begun to emerge as viable alternatives, each with...
Source: Journal of Pain and Palliative Care Pharmacotherapy - February 8, 2024 Category: Palliative Care Authors: Swarali Yatin Chodnekar Nityanand Jain Edouard Lansiaux Deepkanwar Singh Panag Valdis Gibietis Source Type: research
Treatment patterns and characteristics of patients with migraine: results from a retrospective database study in Japan
ConclusionsThis study revealed that approximately one-fifth of the patients with migraine visiting medical facilities use preventive drugs. The presence of potential patients at risk of medication-overuse headache and the role of clinics in migraine treatment were also described. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - February 8, 2024 Category: Neurology Source Type: research
