Efficacy of different routes of acetaminophen administration for postoperative pain in children: a systematic review and network meta-analysis
ConclusionThe available evidence on the effect of the administration route of acetaminophen on postoperative pain in children is very uncertain. The outcomes of postoperative pain control and postoperative vomiting may differ very little between the oral and rectal route. Better designed and executed RCTs are required to address this important clinical question.Study registrationPROSPERO (CRD42021286495); first submitted 19 November 2021. (Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - April 15, 2024 Category: Anesthesiology Source Type: research
GSE255835 The p21+ Perinecrotic Hepatocytes Produce the Chemokine Cxcl14 After a Severe Acetaminophen Overdose Promoting Hepatocyte Injury and Delaying Regeneration
Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 14, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Mus musculus Source Type: research
The p21 < sup > + < /sup > Perinecrotic Hepatocytes Produce the Chemokine CXCL14 After a Severe Acetaminophen Overdose Promoting Hepatocyte Injury and Delaying Regeneration
Toxicology. 2024 Apr 11:153804. doi: 10.1016/j.tox.2024.153804. Online ahead of print.ABSTRACTFifty percent of all acute liver failure (ALF) cases in the United States are due to acetaminophen (APAP) overdose. Assessment of canonical features of liver injury, such as plasma alanine aminotransferase activities are poor predictors of acute liver failure (ALF), suggesting the involvement of additional mechanisms independent of hepatocyte death. Previous work demonstrated a severe overdose of APAP results in impaired regeneration, the induction of senescence by p21, and increased mortality. We hypothesized that a discrete popu...
Source: Toxicology - April 13, 2024 Category: Toxicology Authors: David S Umbaugh Nga T Nguyen Sawyer H Smith Anup Ramachandran Hartmut Jaeschke Source Type: research
The p21 < sup > + < /sup > perinecrotic hepatocytes produce the chemokine CXCL14 after a severe acetaminophen overdose promoting hepatocyte injury and delaying regeneration
Toxicology. 2024 Apr 12;504:153804. doi: 10.1016/j.tox.2024.153804. Online ahead of print.ABSTRACTFifty percent of all acute liver failure (ALF) cases in the United States are due to acetaminophen (APAP) overdose. Assessment of canonical features of liver injury, such as plasma alanine aminotransferase activities are poor predictors of acute liver failure (ALF), suggesting the involvement of additional mechanisms independent of hepatocyte death. Previous work demonstrated a severe overdose of APAP results in impaired regeneration, the induction of senescence by p21, and increased mortality. We hypothesized that a discrete ...
Source: Toxicology - April 13, 2024 Category: Toxicology Authors: David S Umbaugh Nga T Nguyen Sawyer H Smith Anup Ramachandran Hartmut Jaeschke Source Type: research
Novel Topical Treatments for Itch
AbstractThe experience of itch often poses a burden on patient quality of life and has the capacity to inflict significant suffering. Topical therapies are a mainstay of treatment for many cutaneous and systemic diseases and afford patients the opportunity to manage their conditions without many of the systemic side effects of non-topical therapies. We review a multitude of new topical medications targeting the skin, immune system, and neural receptors. The list includes Janus kinase inhibitors, tyrosine kinase inhibitors, phosphodiesterase inhibitors, transient receptor vanilloid inhibitors, topical cannabinoids, and topi...
Source: Dermatology and Therapy - April 13, 2024 Category: Dermatology Source Type: research
Environmental risk assessment of selected pharmaceuticals in hospital wastewater in nothern vietnam
This study investigated the occurrence of selected pharmaceuticals in influent and effluent of wastewater treatment plants of 12 hospitals in Hanoi and 3 northern cities of Vietnam during dry and rainy seasons. In addition, environmental risk of pharmaceuticals in both hospital influents and effluents were evaluated based on risk quotients (RQs). Nine selected pharmaceutical compounds including sulfamethoxazole (SMX), naproxen (NPX), diclofenac (DCF), ibuprofen (IBU), acetaminophen (ACT), carbamazepine (CBM), iopromide (IOP), atenolol (ATN), and caffeine (CAF) were frequently detected in most influent and effluent wastewat...
Source: Chemosphere - April 12, 2024 Category: Chemistry Authors: Anh T P Hoang Manh Cuong Do Kyoung-Woong Kim Source Type: research
Effect of an intravenous acetaminophen/ibuprofen fixed-dose combination on postoperative opioid consumption and pain after video-assisted thoracic surgery: a double-blind randomized controlled trial
ConclusionPerioperative administration of acetaminophen/ibuprofen significantly decreased analgesic needs in patients undergoing VATS, providing an effective postoperative pain management strategy, and potentially minimizing the need for stronger analgesics. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 12, 2024 Category: Surgery Source Type: research
Is postnatal acetaminophen therapy problematic for preterm infants?
Pediatr Res. 2024 Apr 10. doi: 10.1038/s41390-024-03204-5. Online ahead of print.NO ABSTRACTPMID:38600300 | DOI:10.1038/s41390-024-03204-5 (Source: Pediatric Research)
Source: Pediatric Research - April 10, 2024 Category: Pediatrics Authors: Richard J Martin Anna Maria Hibbs Source Type: research
Is postnatal acetaminophen therapy problematic for preterm infants?
Pediatr Res. 2024 Apr 10. doi: 10.1038/s41390-024-03204-5. Online ahead of print.NO ABSTRACTPMID:38600300 | DOI:10.1038/s41390-024-03204-5 (Source: Pediatric Research)
Source: Pediatric Research - April 10, 2024 Category: Pediatrics Authors: Richard J Martin Anna Maria Hibbs Source Type: research
Study Finds No Link Between Acetaminophen Use During Pregnancy And Autism, ADHD Risk
Children exposed to acetaminophen in the womb do not appear to have an increased risk of autism or attention-deficit/hyperactivity disorder (ADHD), according to a studypublished today inJAMA. While a broad analysis of Swedish families found a slightly increased rate of these disorders in children exposed to acetaminophen in the womb, the researchers found no evidence acetaminophen was responsible when factoring in genetic or family influence.“Results of this study indicate that the association between acetaminophen use during pregnancy and neurodevelopmental disorders is a noncausal association.,” wrote Viktor H. Ahlqv...
Source: Psychiatr News - April 9, 2024 Category: Psychiatry Tags: acetaminophen ADHD attention deficit hyperactivity disorder autism JAMA pregnancy risk factor Sweden Tylenol Source Type: research
Acetaminophen Use During Pregnancy and Children ’s Risk of Autism, ADHD, and Intellectual Disability
This nationwide cohort study with sibling control analysis examines the association of acetaminophen use during pregnancy with children ’s risk of autism, ADHD, and intellectual disability. (Source: JAMA)
Source: JAMA - April 9, 2024 Category: General Medicine Source Type: research
Neutrophil extracellular traps promote acetaminophen-induced acute liver injury in mice via AIM2
In this study we investigated whether NETs were involved in hepatocyte injury and contributed to APAP-induced ALI progression. ALI mouse model was established by injecting overdose (350 mg/kg) of APAP. After 24 h, blood and livers were harvested for analyses. We showed that excessive APAP induced multiple programmed cell deaths of hepatocytes including pyroptosis, apoptosis and necroptosis, accompanied by significantly increased NETs markers (MPO, citH3) in the liver tissue and serum. Preinjection of DNase1 (10 U, i.p.) for two consecutive days significantly inhibited NETs formation, reduced PANoptosis and consequently all...
Source: Acta Pharmacologica Sinica - April 8, 2024 Category: Drugs & Pharmacology Authors: Fan-le Zeng Yuan Zhang Zhong-Hao Wang Hui Zhang Xue-Teng Meng Yi-Qin Wu Zhen-Zhen Qian Yu-Hao Ding Jun Li Tao-Tao Ma Cheng Huang Source Type: research
Neutrophil extracellular traps promote acetaminophen-induced acute liver injury in mice via AIM2
In this study we investigated whether NETs were involved in hepatocyte injury and contributed to APAP-induced ALI progression. ALI mouse model was established by injecting overdose (350 mg/kg) of APAP. After 24 h, blood and livers were harvested for analyses. We showed that excessive APAP induced multiple programmed cell deaths of hepatocytes including pyroptosis, apoptosis and necroptosis, accompanied by significantly increased NETs markers (MPO, citH3) in the liver tissue and serum. Preinjection of DNase1 (10 U, i.p.) for two consecutive days significantly inhibited NETs formation, reduced PANoptosis and consequently all...
Source: Acta Pharmacologica Sinica - April 8, 2024 Category: Drugs & Pharmacology Authors: Fan-le Zeng Yuan Zhang Zhong-Hao Wang Hui Zhang Xue-Teng Meng Yi-Qin Wu Zhen-Zhen Qian Yu-Hao Ding Jun Li Tao-Tao Ma Cheng Huang Source Type: research
