Cryopreserved cGMP-compliant human pluripotent stem cell-derived hepatic progenitors rescue mice from acute liver failure through rapid paracrine effects on liver cells

CONCLUSIONS: We generated cryopreserved and current good manufacturing practice-compliant human pluripotent stem cell-derived immature hepatic progenitors that were highly effective in treating acute liver failure through rapid paracrine effects reprogramming endogenous hepatocytes. This is also the first report highlighting that human allogeneic cells could be used as cryopreserved cells and in the absence of immunosuppression for human PSC-based regenerative medicine for acute liver failure.PMID:38475825 | DOI:10.1186/s13287-024-03673-9

Source: Cell Research - March 13, 2024 Category: Cytology Authors: Malika Gantier Rapha ël Rispal Ang élique Fourrier S éverine Ménoret Fr édéric Delbos Ignacio Anegon Tuan Huy Nguyen Source Type: research