The maximum dose of atorvastatin and simvastatin as well as rosuvastatin should be restricted in East Asians
Hong Kong Med J. 2024 Apr 12. doi: 10.12809/hkmj2311348. Online ahead of print.NO ABSTRACTPMID:38605565 | DOI:10.12809/hkmj2311348 (Source: Hong Kong Medical Journal)
Source: Hong Kong Medical Journal - April 12, 2024 Category: General Medicine Authors: B Tomlinson E Chow Source Type: research
The maximum dose of atorvastatin and simvastatin as well as rosuvastatin should be restricted in East Asians
Hong Kong Med J. 2024 Apr 12. doi: 10.12809/hkmj2311348. Online ahead of print.NO ABSTRACTPMID:38605565 | DOI:10.12809/hkmj2311348 (Source: Hong Kong Med J)
Source: Hong Kong Med J - April 12, 2024 Category: General Medicine Authors: B Tomlinson E Chow Source Type: research
The maximum dose of atorvastatin and simvastatin as well as rosuvastatin should be restricted in East Asians
Hong Kong Med J. 2024 Apr 12. doi: 10.12809/hkmj2311348. Online ahead of print.NO ABSTRACTPMID:38605565 | DOI:10.12809/hkmj2311348 (Source: Hong Kong Medical Journal)
Source: Hong Kong Medical Journal - April 12, 2024 Category: General Medicine Authors: B Tomlinson E Chow Source Type: research
Atorvastatin reduces calcification in valve interstitial cells < i > via < /i > the NF- κB signalling pathway by promoting Atg5-mediated autophagy
In conclusion, atorvastatin inhibited the NF- κB signalling pathway by upregulating autophagy, thereby alleviating valve interstitial cell calcification, which was conducive to improving AVC. (Source: European Journal of Histochemistry)
Source: European Journal of Histochemistry - April 12, 2024 Category: Biomedical Science Authors: Menghui Chen, Su Liu Source Type: research
PCSK9i promoting the transformation of AS plaques into a stable plaque by targeting the miR-186-5p/Wipf2 and miR-375-3p/Pdk1/Yap1 in ApoE-/- mice
CONCLUSION: Aberrant miRNA expression may play a pivotal role in AS progression in murine models of AS. The subcutaneous administration of PCSK9i exerted anti-atherosclerotic effects by targeting the miR-186-5p/Wipf2 and miR-375-3p/Pdk1/Yap1 axes, thereby promoting the transition of AS plaques into a more stable form.PMID:38596793 | PMC:PMC11002805 | DOI:10.3389/fmed.2024.1284199 (Source: Atherosclerosis)
Source: Atherosclerosis - April 10, 2024 Category: Cardiology Authors: Yanlong Zhao Ning Liu Jifeng Zhang Lei Zhao Source Type: research
PCSK9i promoting the transformation of AS plaques into a stable plaque by targeting the miR-186-5p/Wipf2 and miR-375-3p/Pdk1/Yap1 in ApoE-/- mice
CONCLUSION: Aberrant miRNA expression may play a pivotal role in AS progression in murine models of AS. The subcutaneous administration of PCSK9i exerted anti-atherosclerotic effects by targeting the miR-186-5p/Wipf2 and miR-375-3p/Pdk1/Yap1 axes, thereby promoting the transition of AS plaques into a more stable form.PMID:38596793 | PMC:PMC11002805 | DOI:10.3389/fmed.2024.1284199 (Source: Atherosclerosis)
Source: Atherosclerosis - April 10, 2024 Category: Cardiology Authors: Yanlong Zhao Ning Liu Jifeng Zhang Lei Zhao Source Type: research
Atorvastatin causes developmental and behavioral toxicity in yellowstripe goby (Mugilogobius chulae) embryos/larvae via disrupting lipid metabolism and autophagy processes
Aquat Toxicol. 2024 Apr 6;271:106909. doi: 10.1016/j.aquatox.2024.106909. Online ahead of print.ABSTRACTAtorvastatin (ATV) is one of the most commonly prescribed lipid-lowering drugs detected frequently in the environment due to its high use and low degradation rate. However, the toxic effects of residual ATV in the aquatic environment on non-target organisms and its toxic mechanisms are still largely unknown. In the present study, embryos of a native estuarine benthic fish, Mugilogobius chulae, were employed to investigate the developmental and behavioral toxic effects of ATV including environmentally relevant concentrati...
Source: Aquatic Toxicology - April 9, 2024 Category: Toxicology Authors: Yufei Zhao Yimeng Wang Jinzhi Ren Weibo Gong Xiangping Nie Ying Peng Jianjun Li Chunni Duan Source Type: research
Assessing the structural stability and drug encapsulation efficiency of poly(ethylene glycol)-poly(L-lactic acid) nanoparticles loaded with atorvastatin calcium: Based on dissipative particle dynamics
This study aims to investigate the structural stability of drug-loading micelles formed by two diblock/triblock polymers with various block sequences through coarse-grained dissipative particle dynamics (DPD) simulations. From the perspectives of the binding strength of poly(L-lactic acid) (PLLA) and polyethylene glycol (PEG) in nanoparticles, hydrophilic bead surface coverage, and the morphological alteration of nanoparticles induced by shear force, the ratio of hydrophilic/hydrophobic sequence length has been observed to affect the stability of nanoparticles. We have found that for diblock polymers, PEG3kda-PLLA2kda has ...
Source: International Journal of Biological Macromolecules - April 9, 2024 Category: Biochemistry Authors: Yun Hao Feng Wei Xin Guo Zhuo Lin Li Liu Fu Hu Yue Liu Li Yue Jing Jianhao Wang Mohammad-Ali Shahbazi Bo Zhi Chen Xin Dong Guo Source Type: research
Atorvastatin causes developmental and behavioral toxicity in yellowstripe goby (Mugilogobius chulae) embryos/larvae via disrupting lipid metabolism and autophagy processes
Aquat Toxicol. 2024 Apr 6;271:106909. doi: 10.1016/j.aquatox.2024.106909. Online ahead of print.ABSTRACTAtorvastatin (ATV) is one of the most commonly prescribed lipid-lowering drugs detected frequently in the environment due to its high use and low degradation rate. However, the toxic effects of residual ATV in the aquatic environment on non-target organisms and its toxic mechanisms are still largely unknown. In the present study, embryos of a native estuarine benthic fish, Mugilogobius chulae, were employed to investigate the developmental and behavioral toxic effects of ATV including environmentally relevant concentrati...
Source: Aquatic Toxicology - April 9, 2024 Category: Toxicology Authors: Yufei Zhao Yimeng Wang Jinzhi Ren Weibo Gong Xiangping Nie Ying Peng Jianjun Li Chunni Duan Source Type: research
Assessing the structural stability and drug encapsulation efficiency of poly(ethylene glycol)-poly(L-lactic acid) nanoparticles loaded with atorvastatin calcium: Based on dissipative particle dynamics
This study aims to investigate the structural stability of drug-loading micelles formed by two diblock/triblock polymers with various block sequences through coarse-grained dissipative particle dynamics (DPD) simulations. From the perspectives of the binding strength of poly(L-lactic acid) (PLLA) and polyethylene glycol (PEG) in nanoparticles, hydrophilic bead surface coverage, and the morphological alteration of nanoparticles induced by shear force, the ratio of hydrophilic/hydrophobic sequence length has been observed to affect the stability of nanoparticles. We have found that for diblock polymers, PEG3kda-PLLA2kda has ...
Source: International Journal of Biological Macromolecules - April 9, 2024 Category: Biochemistry Authors: Yun Hao Feng Wei Xin Guo Zhuo Lin Li Liu Fu Hu Yue Liu Li Yue Jing Jianhao Wang Mohammad-Ali Shahbazi Bo Zhi Chen Xin Dong Guo Source Type: research
Overcoming statin resistance in prostate cancer cells by targeting the 3-hydroxy-3-methylglutaryl-CoA-reductase
Biochem Biophys Res Commun. 2024 Mar 28;710:149841. doi: 10.1016/j.bbrc.2024.149841. Online ahead of print.ABSTRACTProstate cancer is the most prevalent malignancy in men. While diagnostic and therapeutic interventions have substantially improved in recent years, disease relapse, treatment resistance, and metastasis remain significant contributors to prostate cancer-related mortality. Therefore, novel therapeutic approaches are needed. Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway which plays an essential role in cholesterol homeostasis. N...
Source: Biochemical and Biophysical Research communications - April 8, 2024 Category: Biochemistry Authors: Andy G öbel Sophie P ählig Anja Motz Dorit Breining Sofia Traikov Lorenz C Hofbauer Tilman D Rachner Source Type: research
Overcoming statin resistance in prostate cancer cells by targeting the 3-hydroxy-3-methylglutaryl-CoA-reductase
Biochem Biophys Res Commun. 2024 Mar 28;710:149841. doi: 10.1016/j.bbrc.2024.149841. Online ahead of print.ABSTRACTProstate cancer is the most prevalent malignancy in men. While diagnostic and therapeutic interventions have substantially improved in recent years, disease relapse, treatment resistance, and metastasis remain significant contributors to prostate cancer-related mortality. Therefore, novel therapeutic approaches are needed. Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway which plays an essential role in cholesterol homeostasis. N...
Source: Cell Research - April 8, 2024 Category: Cytology Authors: Andy G öbel Sophie P ählig Anja Motz Dorit Breining Sofia Traikov Lorenz C Hofbauer Tilman D Rachner Source Type: research
Overcoming statin resistance in prostate cancer cells by targeting the 3-hydroxy-3-methylglutaryl-CoA-reductase
Biochem Biophys Res Commun. 2024 Mar 28;710:149841. doi: 10.1016/j.bbrc.2024.149841. Online ahead of print.ABSTRACTProstate cancer is the most prevalent malignancy in men. While diagnostic and therapeutic interventions have substantially improved in recent years, disease relapse, treatment resistance, and metastasis remain significant contributors to prostate cancer-related mortality. Therefore, novel therapeutic approaches are needed. Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway which plays an essential role in cholesterol homeostasis. N...
Source: Biochemical and Biophysical Research communications - April 8, 2024 Category: Biochemistry Authors: Andy G öbel Sophie P ählig Anja Motz Dorit Breining Sofia Traikov Lorenz C Hofbauer Tilman D Rachner Source Type: research
Establishment and validation of a CT-based prediction model for the good dissolution of mild chronic subdural hematoma with atorvastatin treatment
ConclusionThe imaging data-based prediction model has demonstrated great prediction accuracy for good hematoma dissolution in mild CSDH patients undergoing atorvastatin treatment. The study results emphasize the importance of imaging data evaluation in the management of CSDH patients. (Source: Neuroradiology)
Source: Neuroradiology - April 8, 2024 Category: Radiology Source Type: research
Clinical effects of atorvastatin combined with conbercept in the treatment of patients with macular edema secondary to retinal vein occlusion and carotid plaque: study protocol for a prospective randomized controlled trial
Intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) drugs have been widely used in patients with macular edema (ME) secondary to retinal vein occlusion (RVO); however, recurrence is ... (Source: Trials)
Source: Trials - April 8, 2024 Category: General Medicine Authors: Bangtao Yao, Bei Wang, Jun Yang, Yan Geng, Hao Yu, Yuhui Liu, Gang Liu and Xiuying Wang Tags: Study protocol Source Type: research
