Early statin exposure influences cardiac and skeletal development with implications for ion channel transcriptomes in zebrafish
In this study, we investigated the developmental effects of two widely used statins, atorvastatin (ATO) and pravastatin (PRA), on zebrafish offspring. For ATO, we administered doses classified as low (1 μM), medium (5 μM), and high (10 μM), while for PRA, the corresponding concentrations were set at low (18 μM), medium (180 μM), and high (270 μM). Our results showed significant reductions in birth and hatching rates, along with decreased body length in offspring at all ATO concentrations and medium to high PRA concentrations. A notable increase in malformation rates, especially in the spine and heart, was observed ac...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Ying Zhao Hou-Zhi Yang Huinan Li Shuang Liang Meng Wang Chun-Di Li Donghai Zhuo Feifei Fan Miao Guo Xinxin Lv Lingzhu Zhang Xu Chen Shan-Shan Li Xin Jin Source Type: research
Early statin exposure influences cardiac and skeletal development with implications for ion channel transcriptomes in zebrafish
In this study, we investigated the developmental effects of two widely used statins, atorvastatin (ATO) and pravastatin (PRA), on zebrafish offspring. For ATO, we administered doses classified as low (1 μM), medium (5 μM), and high (10 μM), while for PRA, the corresponding concentrations were set at low (18 μM), medium (180 μM), and high (270 μM). Our results showed significant reductions in birth and hatching rates, along with decreased body length in offspring at all ATO concentrations and medium to high PRA concentrations. A notable increase in malformation rates, especially in the spine and heart, was observed ac...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Ying Zhao Hou-Zhi Yang Huinan Li Shuang Liang Meng Wang Chun-Di Li Donghai Zhuo Feifei Fan Miao Guo Xinxin Lv Lingzhu Zhang Xu Chen Shan-Shan Li Xin Jin Source Type: research
Early statin exposure influences cardiac and skeletal development with implications for ion channel transcriptomes in zebrafish
In this study, we investigated the developmental effects of two widely used statins, atorvastatin (ATO) and pravastatin (PRA), on zebrafish offspring. For ATO, we administered doses classified as low (1 μM), medium (5 μM), and high (10 μM), while for PRA, the corresponding concentrations were set at low (18 μM), medium (180 μM), and high (270 μM). Our results showed significant reductions in birth and hatching rates, along with decreased body length in offspring at all ATO concentrations and medium to high PRA concentrations. A notable increase in malformation rates, especially in the spine and heart, was observed ac...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Ying Zhao Hou-Zhi Yang Huinan Li Shuang Liang Meng Wang Chun-Di Li Donghai Zhuo Feifei Fan Miao Guo Xinxin Lv Lingzhu Zhang Xu Chen Shan-Shan Li Xin Jin Source Type: research
Early statin exposure influences cardiac and skeletal development with implications for ion channel transcriptomes in zebrafish
In this study, we investigated the developmental effects of two widely used statins, atorvastatin (ATO) and pravastatin (PRA), on zebrafish offspring. For ATO, we administered doses classified as low (1 μM), medium (5 μM), and high (10 μM), while for PRA, the corresponding concentrations were set at low (18 μM), medium (180 μM), and high (270 μM). Our results showed significant reductions in birth and hatching rates, along with decreased body length in offspring at all ATO concentrations and medium to high PRA concentrations. A notable increase in malformation rates, especially in the spine and heart, was observed ac...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Ying Zhao Hou-Zhi Yang Huinan Li Shuang Liang Meng Wang Chun-Di Li Donghai Zhuo Feifei Fan Miao Guo Xinxin Lv Lingzhu Zhang Xu Chen Shan-Shan Li Xin Jin Source Type: research
Early statin exposure influences cardiac and skeletal development with implications for ion channel transcriptomes in zebrafish
In this study, we investigated the developmental effects of two widely used statins, atorvastatin (ATO) and pravastatin (PRA), on zebrafish offspring. For ATO, we administered doses classified as low (1 μM), medium (5 μM), and high (10 μM), while for PRA, the corresponding concentrations were set at low (18 μM), medium (180 μM), and high (270 μM). Our results showed significant reductions in birth and hatching rates, along with decreased body length in offspring at all ATO concentrations and medium to high PRA concentrations. A notable increase in malformation rates, especially in the spine and heart, was observed ac...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Ying Zhao Hou-Zhi Yang Huinan Li Shuang Liang Meng Wang Chun-Di Li Donghai Zhuo Feifei Fan Miao Guo Xinxin Lv Lingzhu Zhang Xu Chen Shan-Shan Li Xin Jin Source Type: research
Early statin exposure influences cardiac and skeletal development with implications for ion channel transcriptomes in zebrafish
In this study, we investigated the developmental effects of two widely used statins, atorvastatin (ATO) and pravastatin (PRA), on zebrafish offspring. For ATO, we administered doses classified as low (1 μM), medium (5 μM), and high (10 μM), while for PRA, the corresponding concentrations were set at low (18 μM), medium (180 μM), and high (270 μM). Our results showed significant reductions in birth and hatching rates, along with decreased body length in offspring at all ATO concentrations and medium to high PRA concentrations. A notable increase in malformation rates, especially in the spine and heart, was observed ac...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Ying Zhao Hou-Zhi Yang Huinan Li Shuang Liang Meng Wang Chun-Di Li Donghai Zhuo Feifei Fan Miao Guo Xinxin Lv Lingzhu Zhang Xu Chen Shan-Shan Li Xin Jin Source Type: research
Early statin exposure influences cardiac and skeletal development with implications for ion channel transcriptomes in zebrafish
In this study, we investigated the developmental effects of two widely used statins, atorvastatin (ATO) and pravastatin (PRA), on zebrafish offspring. For ATO, we administered doses classified as low (1 μM), medium (5 μM), and high (10 μM), while for PRA, the corresponding concentrations were set at low (18 μM), medium (180 μM), and high (270 μM). Our results showed significant reductions in birth and hatching rates, along with decreased body length in offspring at all ATO concentrations and medium to high PRA concentrations. A notable increase in malformation rates, especially in the spine and heart, was observed ac...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Ying Zhao Hou-Zhi Yang Huinan Li Shuang Liang Meng Wang Chun-Di Li Donghai Zhuo Feifei Fan Miao Guo Xinxin Lv Lingzhu Zhang Xu Chen Shan-Shan Li Xin Jin Source Type: research
Early microvascular coronary endothelial dysfunction precedes pembrolizumab-induced cardiotoxicity. Preventive role of high dose of atorvastatin
AbstractImmune checkpoint inhibitors (ICIs) exhibit remarkable antitumor activity and immune-related cardiotoxicity of unknown pathomechanism. The aim of the study was to investigate the ICI class-dependent cardiotoxicity in vitro and pembrolizumab ’s (Pem’s) cardiotoxicity in vivo, seeking for translational prevention means. Cytotoxicity was investigated in primary cardiomyocytes and splenocytes, incubated with ipilimumab, Pem and avelumab. Pem’s cross-reactivity was assessed by circular dichroism (CD) on biotechnologically produced hum an and murine PD-1 and in silico. C57BL6/J male mice received IgG4 or Pem for 2 ...
Source: Basic Research in Cardiology - March 23, 2024 Category: Cardiology Source Type: research
Clinical Analysis of Atorvastatin Calcium, Fenofibrate, and Acipimox in the Treatment of Hypertriglyceridemia-induced Acute Pancreatitis
CONCLUSION: The findings of this study highlight the effectiveness of combining fenofibrate and acipimox in the treatment of HTG-AP, leading to rapid disease recovery and significant improvement in clinical symptoms. These results have important implications for clinical practice, as the combination therapy can be widely adopted as an effective treatment strategy for HTG-AP patients. Moreover, this study provides valuable insights into the management of HTG-AP and suggests that lipid-lowering agents, such as atorvastatin calcium and fenofibrate, play a crucial role in the treatment of this condition. However, further resea...
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Limin Tong Suqiong Xu Zhiyong Chen Jian Gao Qinghua Huang Xinhua Lin Sihua Lin Zhiteng Lin Yongxuan Zheng Source Type: research
Clinical Analysis of Atorvastatin Calcium, Fenofibrate, and Acipimox in the Treatment of Hypertriglyceridemia-induced Acute Pancreatitis
CONCLUSION: The findings of this study highlight the effectiveness of combining fenofibrate and acipimox in the treatment of HTG-AP, leading to rapid disease recovery and significant improvement in clinical symptoms. These results have important implications for clinical practice, as the combination therapy can be widely adopted as an effective treatment strategy for HTG-AP patients. Moreover, this study provides valuable insights into the management of HTG-AP and suggests that lipid-lowering agents, such as atorvastatin calcium and fenofibrate, play a crucial role in the treatment of this condition. However, further resea...
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Limin Tong Suqiong Xu Zhiyong Chen Jian Gao Qinghua Huang Xinhua Lin Sihua Lin Zhiteng Lin Yongxuan Zheng Source Type: research
Clinical Analysis of Atorvastatin Calcium, Fenofibrate, and Acipimox in the Treatment of Hypertriglyceridemia-induced Acute Pancreatitis
CONCLUSION: The findings of this study highlight the effectiveness of combining fenofibrate and acipimox in the treatment of HTG-AP, leading to rapid disease recovery and significant improvement in clinical symptoms. These results have important implications for clinical practice, as the combination therapy can be widely adopted as an effective treatment strategy for HTG-AP patients. Moreover, this study provides valuable insights into the management of HTG-AP and suggests that lipid-lowering agents, such as atorvastatin calcium and fenofibrate, play a crucial role in the treatment of this condition. However, further resea...
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Limin Tong Suqiong Xu Zhiyong Chen Jian Gao Qinghua Huang Xinhua Lin Sihua Lin Zhiteng Lin Yongxuan Zheng Source Type: research
Clinical Analysis of Atorvastatin Calcium, Fenofibrate, and Acipimox in the Treatment of Hypertriglyceridemia-induced Acute Pancreatitis
CONCLUSION: The findings of this study highlight the effectiveness of combining fenofibrate and acipimox in the treatment of HTG-AP, leading to rapid disease recovery and significant improvement in clinical symptoms. These results have important implications for clinical practice, as the combination therapy can be widely adopted as an effective treatment strategy for HTG-AP patients. Moreover, this study provides valuable insights into the management of HTG-AP and suggests that lipid-lowering agents, such as atorvastatin calcium and fenofibrate, play a crucial role in the treatment of this condition. However, further resea...
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Limin Tong Suqiong Xu Zhiyong Chen Jian Gao Qinghua Huang Xinhua Lin Sihua Lin Zhiteng Lin Yongxuan Zheng Source Type: research
Astragaloside IV attenuates renal tubule injury in DKD rats via suppression of CD36-mediated NLRP3 inflammasome activation
Conclusion:AS-IV alleviated renal tubule interstitial inflammation and tubule epithelial cell apoptosis in DKD rats by inhibiting CD36-mediated lipid accumulation and NLRP3 inflammasome activation. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 20, 2024 Category: Drugs & Pharmacology Source Type: research
Genome-Wide Association Study of Atorvastatin Pharmacokinetics: Associations With SLCO1B1, UGT1A3, and LPP
Clin Pharmacol Ther. 2024 Mar 17. doi: 10.1002/cpt.3236. Online ahead of print.ABSTRACTIn a genome-wide association study of atorvastatin pharmacokinetics in 158 healthy volunteers, the SLCO1B1 c.521T>C (rs4149056) variant associated with increased area under the plasma concentration-time curve from time zero to infinity (AUC0-∞ ) of atorvastatin (P = 1.2 × 10-10 ), 2-hydroxy atorvastatin (P = 4.0 × 10-8 ), and 4-hydroxy atorvastatin (P = 2.9 × 10-8 ). An intronic LPP variant, rs1975991, associated with reduced atorvastatin lactone AUC0-∞ (P = 3.8 × 10-8 ). Three UGT1A variants linked with UGT1A3*2 associated wi...
Source: Clinical Pharmacology and Therapeutics - March 17, 2024 Category: Drugs & Pharmacology Authors: Anssi J H Mykk änen E Katriina Tarkiainen Suvi Taskinen Mikko Neuvonen Maria Paile-Hyv ärinen Tuomas O Lilius Tuija Tapaninen Kathrin Klein Matthias Schwab Janne T Backman Aleksi Tornio Mikko Niemi Source Type: research
Effect of combining evolocumab with statin on carotid intraplaque neovascularization in patients with premature coronary artery disease (EPOCH)
CONCLUSIONS: If compared to placebo, the PCSK9 inhibitor evolocumab combined with statins resulted in a greater decrease in LDL-C and plaque neovascularization in Chinese patients with PCAD.PMID:38493669 | DOI:10.1016/j.atherosclerosis.2024.117471 (Source: Atherosclerosis)
Source: Atherosclerosis - March 17, 2024 Category: Cardiology Authors: Yanyan Han Ling Ren Xiang Fei Jingjing Wang Tao Chen Jun Guo Qi Wang Source Type: research
