Statins and thyroid eye disease (TED): a systematic review
ConclusionStatin therapy could be a potential adjunctive modality for preventing and treating TED.Trial registrationPROSPERO registration number: CRD42022315522. (Source: Endocrine)
Source: Endocrine - January 9, 2024 Category: Endocrinology Source Type: research
Zexieyin formula alleviates atherosclerosis with cognitive impairment: A novel role in the treatment of comorbidities and its underlying mechanisms
CONCLUSIONS: ZXYF mitigated AS, further alleviating CI by modulating MAPK signaling, relating to synaptic proteins enhancing and Aβ protein decreasing in the hippocampus. This study firstly lit up the new clinical application of ZXYF, which might promote the use of ZXYF in AS and CI patients.PMID:38181934 | DOI:10.1016/j.jep.2024.117715 (Source: Atherosclerosis)
Source: Atherosclerosis - January 5, 2024 Category: Cardiology Authors: Yan Sun Hailou Zhang Ruiyi Liu Shan Xing Rumin Huang Dong Di Xiyuan Zhang Boran Zhu Haoxin Wu Source Type: research
Atorvastatin-associated myotoxicity: A toxicokinetic review of pharmacogenetic associations to evaluate the feasibility of precision pharmacotherapy
Clin Biochem. 2024 Jan 3:110707. doi: 10.1016/j.clinbiochem.2024.110707. Online ahead of print.ABSTRACTAtorvastatin (ATV) and other statins are highly effective in reducing cholesterol levels. However, in some patients, the development of drug-associated muscle side effects remains an issue as it compromises the adherence to treatment. Since the toxicity is dose-dependent, exploring factors modulating pharmacokinetics (PK) appears fundamental. The purpose of this review aims at reporting the current state of knowledge about the singular genetic susceptibilities influencing the risk of developing ATV muscle adverse events t...
Source: Clinical Biochemistry - January 5, 2024 Category: Biochemistry Authors: Hoste Emilia Haufroid Vincent Deldicque Louise Balligand Jean-Luc Elens Laure Source Type: research
Atorvastatin-associated myotoxicity: A toxicokinetic review of pharmacogenetic associations to evaluate the feasibility of precision pharmacotherapy
Clin Biochem. 2024 Jan 3:110707. doi: 10.1016/j.clinbiochem.2024.110707. Online ahead of print.ABSTRACTAtorvastatin (ATV) and other statins are highly effective in reducing cholesterol levels. However, in some patients, the development of drug-associated muscle side effects remains an issue as it compromises the adherence to treatment. Since the toxicity is dose-dependent, exploring factors modulating pharmacokinetics (PK) appears fundamental. The purpose of this review aims at reporting the current state of knowledge about the singular genetic susceptibilities influencing the risk of developing ATV muscle adverse events t...
Source: Clinical Biochemistry - January 5, 2024 Category: Biochemistry Authors: Hoste Emilia Haufroid Vincent Deldicque Louise Balligand Jean-Luc Elens Laure Source Type: research
Atorvastatin-associated myotoxicity: A toxicokinetic review of pharmacogenetic associations to evaluate the feasibility of precision pharmacotherapy
Clin Biochem. 2024 Jan 3:110707. doi: 10.1016/j.clinbiochem.2024.110707. Online ahead of print.ABSTRACTAtorvastatin (ATV) and other statins are highly effective in reducing cholesterol levels. However, in some patients, the development of drug-associated muscle side effects remains an issue as it compromises the adherence to treatment. Since the toxicity is dose-dependent, exploring factors modulating pharmacokinetics (PK) appears fundamental. The purpose of this review aims at reporting the current state of knowledge about the singular genetic susceptibilities influencing the risk of developing ATV muscle adverse events t...
Source: Clinical Biochemistry - January 5, 2024 Category: Biochemistry Authors: Hoste Emilia Haufroid Vincent Deldicque Louise Balligand Jean-Luc Elens Laure Source Type: research
Gelatin-decorated Graphene oxide: A nanocarrier for delivering pH-responsive drug for improving therapeutic efficacy against atherosclerotic plaque
Int J Pharm. 2024 Jan 2:123737. doi: 10.1016/j.ijpharm.2023.123737. Online ahead of print.ABSTRACTThe progressive inflammatory disease atherosclerosis promotes myocardial infection, stroke, and heart attack. Anti-inflammatory drugs treat severe atherosclerosis. They are inadequate bioavailability and cause adverse effects at higher doses. A new nanomaterial coupled pH-apperceptive drug delivery system for atherosclerotic plaque is outlined here. We have synthesized a Graphene Oxide-Gelatin-Atorvastatin (GO-Gel-ATR) nanodrug characterized by spectroscopic and imaging techniques. The encapsulation efficiency of GO-Gel-ATR (7...
Source: Atherosclerosis - January 4, 2024 Category: Cardiology Authors: Sandeep Kumar Yadav Shreyasi Das Abhijit Lincon Saradindu Saha Somdeb BoseDasgupta Samit K Ray Soumen Das Source Type: research
Gelatin-decorated Graphene oxide: A nanocarrier for delivering pH-responsive drug for improving therapeutic efficacy against atherosclerotic plaque
Int J Pharm. 2024 Jan 2:123737. doi: 10.1016/j.ijpharm.2023.123737. Online ahead of print.ABSTRACTThe progressive inflammatory disease atherosclerosis promotes myocardial infection, stroke, and heart attack. Anti-inflammatory drugs treat severe atherosclerosis. They are inadequate bioavailability and cause adverse effects at higher doses. A new nanomaterial coupled pH-apperceptive drug delivery system for atherosclerotic plaque is outlined here. We have synthesized a Graphene Oxide-Gelatin-Atorvastatin (GO-Gel-ATR) nanodrug characterized by spectroscopic and imaging techniques. The encapsulation efficiency of GO-Gel-ATR (7...
Source: Atherosclerosis - January 4, 2024 Category: Cardiology Authors: Sandeep Kumar Yadav Shreyasi Das Abhijit Lincon Saradindu Saha Somdeb BoseDasgupta Samit K Ray Soumen Das Source Type: research
Risk Factors Analysis of Severe Liver Injury Induced by
Statins
Horm Metab Res DOI: 10.1055/a-2210-3395The aim of this study is to report the risk factors of severe statin induced
liver injury (SILI). From the database of Shandong ADR Monitoring Center and
Outpatients and inpatients in our hospital, SILI cases reported from 2013 to
2021 were extracted and screened. The diagnostic criteria of SILI, the inclusion
and exclusion criteria of severe and general SILI were established separately.
After the SILI cases were selected and confirmed, the socio-demographic and
clinical characteristics were collected. Single factor chi-squar...
Source: Hormone and Metabolic Research - January 3, 2024 Category: Endocrinology Authors: Su, Feng-yun Li, Wen-hua Zhao, Xu-dong Han, Qian Xu, Xin Geng, Tao Tags: Original Article: Endocrine Care Source Type: research
GSE242401 The ROR ɣ/SREBP2 pathway is a master regulator of cholesterol metabolism and serves as potential therapeutic target in t(4;11) leukemia
Contributors : Estelle Erkner ; Thomas Hentrich ; Julia Schulze-Hentrich ; Corina SchneidawindSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDysregulated cholesterol homeostasis promotes tumorigenesis and progression. Therefore, metabolic reprogramming constitutes a new hallmark of cancer. However, until today, only few therapeutic approaches exist to target this pathway due to the often-observed negative feedback induced by agents like statins leading to controversially increased cholesterol synthesis upon inhibition. Sterol regulatory element-binding proteins (SREBPs) are key t...
Source: GEO: Gene Expression Omnibus - January 1, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Incidence Of Adverse Events Is Higher When Heart Transplant Recipients Are On High Versus Standard Dose Statin In Combination With Cyclosporine
Heart transplant recipients receive a calcineurin inhibitor (CNI) for immunosuppression. While tacrolimus is the CNI of choice, switching to cyclosporine (CSA) may be necessary due to side effects. Treatment with a statin decreases incidence of cardiac allograft vasculopathy and mortality post-transplant. CSA interacts with statins by increasing their levels, with high intensity statins often contraindicated. Per the AHA, maximum recommended statin doses for heart transplants on CSA include atorvastatin 10 mg, pravastatin 20 mg, rosuvastatin 5 mg, and fluvastatin 40 mg. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Gabriel E. Diaz, Besher Kashlan, Cole Block, Jenna Negrelli, Michelle Fine, Joshua Newman, Mingxi D. Yu, Max Liebo Tags: 153 Source Type: research
Huatanmaitong tablet alleviate cerebral ischemic reperfusion injury with hyperlipidaemia in rats by regulating OATPs/VEGF axis
Cell Mol Biol (Noisy-le-grand). 2023 Dec 10;69(13):235-240. doi: 10.14715/cmb/2023.69.13.35.ABSTRACTStroke is the top priority pathogenesis of disability and death globally, affecting people worldwide. The presence of high levels of lipids in the blood has been confirmed as a vital factor of ischemic stroke. We aim to examine the effectiveness of Huatanmaitong tablet in hyperlipidemia rats that have experienced an ischemic stroke. We created a rat model of middle cerebral artery occlusion (MCAO) with hyperlipidemia as a basis. Following 8 weeks of high-fat diet, the model rats underwent MCAO surgery. Subsequently, the rats...
Source: Cellular and Molecular Biology - December 30, 2023 Category: Molecular Biology Authors: Shuangxi Sun Qi Wang Hongxia Chen Ruihuan Pan Source Type: research
Macrophage-targeted ultrasound nanobubbles for highly efficient sonodynamic therapy of atherosclerotic plaques by modulating M1-to-M2 polarization
CONCLUSIONS: Macrophage-targeted nanoplatform SR-A-Ce6NB-mediated SDT provides a safe, effective and preferable anti-atherogenic therapy by mediating M1-to-M2 macrophage polarization.PMID:38159431 | DOI:10.1016/j.atherosclerosis.2023.117423 (Source: Atherosclerosis)
Source: Atherosclerosis - December 30, 2023 Category: Cardiology Authors: Yueying Chen Hao Wang Juhong Pan Yuxin Guo Yugang Hu Xin Huang Yanxiang Zhou Qing Deng Qing Zhou Source Type: research
Effects of Apex Size on Dissolution Profiles in the USP II Paddle Apparatus
This study aimed to clarify how different apex vessel sizes affect the dissolution behavior of cone-forming formulations. Five apex vessels with different heights, centralities, and compendial vessels were used. The paddle rotation speed at which the coning phenomenon resolved was measured using standard particles of different densities. Three model formulations-USP prednisone tablets, atorvastatin calcium hydrate tablets, and levofloxacin fine granules-were selected, and dissolution tests were conducted at 30-100 revolutions per minute (rpm). Compared to the compendial vessels, the disappearance of standard particles at t...
Source: AAPS PharmSciTech - December 29, 2023 Category: Drugs & Pharmacology Authors: Hiroyuki Yoshida Tokio Morita Yasuhiro Abe Aoi Inagaki Naomi Tomita Ken-Ichi Izutsu Yoji Sato Source Type: research
Effects of Apex Size on Dissolution Profiles in the USP II Paddle Apparatus
This study aimed to clarify how different apex vessel sizes affect the dissolution behavior of cone-forming formulations. Five apex vessels with different heights, centralities, and compendial vessels were used. The paddle rotation speed at which the coning phenomenon resolved was measured using standard particles of different densities. Three model formulations-USP prednisone tablets, atorvastatin calcium hydrate tablets, and levofloxacin fine granules-were selected, and dissolution tests were conducted at 30-100 revolutions per minute (rpm). Compared to the compendial vessels, the disappearance of standard particles at t...
Source: AAPS PharmSciTech - December 29, 2023 Category: Drugs & Pharmacology Authors: Hiroyuki Yoshida Tokio Morita Yasuhiro Abe Aoi Inagaki Naomi Tomita Ken-Ichi Izutsu Yoji Sato Source Type: research
