Appropriateness of Intensive Statin Treatment in People with Type Two Diabetes and Mild Hypercholesterolemia: A Randomized Clinical Trial
CONCLUSION: Despite the general conception, moderate-intensity statins are not adequate for the majority of patients with T2DM and mild hyperlipidemia and greater numbers of patients could reach the LDL cholesterol target with high-intensity statin therapy.PMID:38310429 | PMC:PMC10685836 | DOI:10.34172/aim.2023.45 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - February 4, 2024 Category: Middle East Health Authors: Mohammad Taghi Gorji Fariba Alaei-Shahmiri Gisoo Darban Hosseini Amirkhiz Seyed Hashem Sezavar Mojtaba Malek Mohammad E Khamseh Source Type: research
Appropriateness of Intensive Statin Treatment in People with Type Two Diabetes and Mild Hypercholesterolemia: A Randomized Clinical Trial
CONCLUSION: Despite the general conception, moderate-intensity statins are not adequate for the majority of patients with T2DM and mild hyperlipidemia and greater numbers of patients could reach the LDL cholesterol target with high-intensity statin therapy.PMID:38310429 | PMC:PMC10685836 | DOI:10.34172/aim.2023.45 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - February 4, 2024 Category: Middle East Health Authors: Mohammad Taghi Gorji Fariba Alaei-Shahmiri Gisoo Darban Hosseini Amirkhiz Seyed Hashem Sezavar Mojtaba Malek Mohammad E Khamseh Source Type: research
Appropriateness of Intensive Statin Treatment in People with Type Two Diabetes and Mild Hypercholesterolemia: A Randomized Clinical Trial
CONCLUSION: Despite the general conception, moderate-intensity statins are not adequate for the majority of patients with T2DM and mild hyperlipidemia and greater numbers of patients could reach the LDL cholesterol target with high-intensity statin therapy.PMID:38310429 | PMC:PMC10685836 | DOI:10.34172/aim.2023.45 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - February 4, 2024 Category: Middle East Health Authors: Mohammad Taghi Gorji Fariba Alaei-Shahmiri Gisoo Darban Hosseini Amirkhiz Seyed Hashem Sezavar Mojtaba Malek Mohammad E Khamseh Source Type: research
Appropriateness of Intensive Statin Treatment in People with Type Two Diabetes and Mild Hypercholesterolemia: A Randomized Clinical Trial
CONCLUSION: Despite the general conception, moderate-intensity statins are not adequate for the majority of patients with T2DM and mild hyperlipidemia and greater numbers of patients could reach the LDL cholesterol target with high-intensity statin therapy.PMID:38310429 | PMC:PMC10685836 | DOI:10.34172/aim.2023.45 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - February 4, 2024 Category: Middle East Health Authors: Mohammad Taghi Gorji Fariba Alaei-Shahmiri Gisoo Darban Hosseini Amirkhiz Seyed Hashem Sezavar Mojtaba Malek Mohammad E Khamseh Source Type: research
Appropriateness of Intensive Statin Treatment in People with Type Two Diabetes and Mild Hypercholesterolemia: A Randomized Clinical Trial
CONCLUSION: Despite the general conception, moderate-intensity statins are not adequate for the majority of patients with T2DM and mild hyperlipidemia and greater numbers of patients could reach the LDL cholesterol target with high-intensity statin therapy.PMID:38310429 | PMC:PMC10685836 | DOI:10.34172/aim.2023.45 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - February 4, 2024 Category: Middle East Health Authors: Mohammad Taghi Gorji Fariba Alaei-Shahmiri Gisoo Darban Hosseini Amirkhiz Seyed Hashem Sezavar Mojtaba Malek Mohammad E Khamseh Source Type: research
Appropriateness of Intensive Statin Treatment in People with Type Two Diabetes and Mild Hypercholesterolemia: A Randomized Clinical Trial
CONCLUSION: Despite the general conception, moderate-intensity statins are not adequate for the majority of patients with T2DM and mild hyperlipidemia and greater numbers of patients could reach the LDL cholesterol target with high-intensity statin therapy.PMID:38310429 | PMC:PMC10685836 | DOI:10.34172/aim.2023.45 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - February 4, 2024 Category: Middle East Health Authors: Mohammad Taghi Gorji Fariba Alaei-Shahmiri Gisoo Darban Hosseini Amirkhiz Seyed Hashem Sezavar Mojtaba Malek Mohammad E Khamseh Source Type: research
Appropriateness of Intensive Statin Treatment in People with Type Two Diabetes and Mild Hypercholesterolemia: A Randomized Clinical Trial
CONCLUSION: Despite the general conception, moderate-intensity statins are not adequate for the majority of patients with T2DM and mild hyperlipidemia and greater numbers of patients could reach the LDL cholesterol target with high-intensity statin therapy.PMID:38310429 | PMC:PMC10685836 | DOI:10.34172/aim.2023.45 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - February 4, 2024 Category: Middle East Health Authors: Mohammad Taghi Gorji Fariba Alaei-Shahmiri Gisoo Darban Hosseini Amirkhiz Seyed Hashem Sezavar Mojtaba Malek Mohammad E Khamseh Source Type: research
Appropriateness of Intensive Statin Treatment in People with Type Two Diabetes and Mild Hypercholesterolemia: A Randomized Clinical Trial
CONCLUSION: Despite the general conception, moderate-intensity statins are not adequate for the majority of patients with T2DM and mild hyperlipidemia and greater numbers of patients could reach the LDL cholesterol target with high-intensity statin therapy.PMID:38310429 | PMC:PMC10685836 | DOI:10.34172/aim.2023.45 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - February 4, 2024 Category: Middle East Health Authors: Mohammad Taghi Gorji Fariba Alaei-Shahmiri Gisoo Darban Hosseini Amirkhiz Seyed Hashem Sezavar Mojtaba Malek Mohammad E Khamseh Source Type: research
Appropriateness of Intensive Statin Treatment in People with Type Two Diabetes and Mild Hypercholesterolemia: A Randomized Clinical Trial
CONCLUSION: Despite the general conception, moderate-intensity statins are not adequate for the majority of patients with T2DM and mild hyperlipidemia and greater numbers of patients could reach the LDL cholesterol target with high-intensity statin therapy.PMID:38310429 | PMC:PMC10685836 | DOI:10.34172/aim.2023.45 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - February 4, 2024 Category: Middle East Health Authors: Mohammad Taghi Gorji Fariba Alaei-Shahmiri Gisoo Darban Hosseini Amirkhiz Seyed Hashem Sezavar Mojtaba Malek Mohammad E Khamseh Source Type: research
Appropriateness of Intensive Statin Treatment in People with Type Two Diabetes and Mild Hypercholesterolemia: A Randomized Clinical Trial
CONCLUSION: Despite the general conception, moderate-intensity statins are not adequate for the majority of patients with T2DM and mild hyperlipidemia and greater numbers of patients could reach the LDL cholesterol target with high-intensity statin therapy.PMID:38310429 | PMC:PMC10685836 | DOI:10.34172/aim.2023.45 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - February 4, 2024 Category: Middle East Health Authors: Mohammad Taghi Gorji Fariba Alaei-Shahmiri Gisoo Darban Hosseini Amirkhiz Seyed Hashem Sezavar Mojtaba Malek Mohammad E Khamseh Source Type: research
Statins affect human iPSC-derived cardiomyocytes by interfering with mitochondrial function and intracellular acidification
AbstractStatins are effective drugs in reducing cardiovascular morbidity and mortality by inhibiting cholesterol synthesis. These effects are primarily beneficial for the patient ’s vascular system. A significant number of statin users suffer from muscle complaints probably due to mitochondrial dysfunction, a mechanism that has recently been elucidated. This has raised our interest in exploring the effects of statins on cardiac muscle cells in an era where the elderly and patients with poorer functioning hearts and less metabolic spare capacity start dominating our patient population. Here, we investigated the effects of...
Source: Basic Research in Cardiology - February 2, 2024 Category: Cardiology Source Type: research
Activation of AMPK pathway by low ‑dose donafenib and atorvastatin combination improves high‑fat diet‑induced metabolic dysfunction‑associated steatotic liver disease
Mol Med Rep. 2024 Mar;29(3):51. doi: 10.3892/mmr.2024.13175. Epub 2024 Feb 1.ABSTRACTMetabolic dysfunction‑associated steatotic liver disease (MASLD) is an increasingly significant global health burden for which there is currently no effective treatment. The present study aimed to explore the underlying mechanisms and investigate the effects of donafenib and atorvastatin in MASLD. The effects of donafenib and atorvastatin on the activity and lipid metabolism of HepG2 cells were analyzed in vitro. A rat model of MASLD was established induced by a high‑fat diet in vivo. H&E and Oil red O staining were used to observe...
Source: Molecular Medicine Reports - February 1, 2024 Category: Molecular Biology Authors: Yaowei Bai Kequan Chen Jiacheng Liu Yingliang Wang Chaoyang Wang Shuguang Ju Chen Zhou Wei Yao Bin Xiong Chuansheng Zheng Source Type: research
Identification of MGMT promoter methylation as a specific lipid metabolism biomarker, reveals the feasibility of atorvastatin application in glioblastoma
Glioblastoma is one of the deadliest tumors, and limited improvement in managing glioblastoma has been achieved in the past decades. The unmethylated promoter area of 6-O-Methylguanine-DNA Methyltransferase (MGMT) is a significant biomarker for recognizing a subset of glioblastoma that is resistant to chemotherapy. Here we identified MGMT methylation can also work as a specific biomarker to classify the lipid metabolism patterns between methylated and unmethylated glioblastoma and verify the potential novel therapeutic strategy for unmethylated MGMT glioblastoma. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - January 30, 2024 Category: Biomedical Science Authors: Zhaonian Hao, Jiejun Wang, Yifan Lv, Weiqi Wu, Shaodong Zhang, Shuyu Hao, Junsheng Chu, Hong Wan, Jie Feng, Nan Ji Source Type: research
Statin-related neurocognitive disorder: a real-world pharmacovigilance study based on the FDA adverse event reporting system
CONCLUSIONS: This study suggests a significant association between the NCDE and statins, including atorvastatin, simvastatin, and pravastatin. The intensity of the association increased with age.PMID:38275183 | DOI:10.1080/17512433.2024.2311875 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - January 26, 2024 Category: Drugs & Pharmacology Authors: Min Xiao Li Li Weiwei Zhu Fengbo Wu Bin Wu Source Type: research
