Efficacy of Jiangzhi Xiaoban tablet on toll-like receptor 4/nuclear factor-kappa B/nod-like receptor protein 3 signaling pathway in mice with atherosclerosis induced by high-fat diet
CONCLUSION: JZXB has inhibitory effect on atherosclerosis in mice, and its mechanism may be through regulating the TLR4/NF-κB/NLRP3 signaling pathway and reducing the inflammatory response, so as to play a role in inhibiting atherosclerosis.PMID:38213243 | PMC:PMC10774719 | DOI:10.19852/j.cnki.jtcm.20231121.002 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 12, 2024 Category: Complementary Medicine Authors: Liu Huihui Feng Jun Liu Jianhe Cheng Choufu H U Guoheng Source Type: research
Taohong Siwu decoction ameliorates atherosclerosis in rats possibly through toll-like receptor 4/myeloid differentiation primary response protein 88/nuclear factor- κB signal pathway
CONCLUSIONS: TSD can ameliorate atherosclerosis in rats, and the underlying mechanism is supposed be related to the suppression of inflammatory response by regulating TLR4/MyD88/NF-κB signal pathway.PMID:38213245 | PMC:PMC10774721 | DOI:10.19852/j.cnki.jtcm.20231215.003 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 12, 2024 Category: Complementary Medicine Authors: Chang Fengjin Zhou Peng L I Guoying Zhang Weizhi Zhang Yanyan Peng Daiyin Chen Guangliang Source Type: research
Efficacy of Jiangzhi Xiaoban tablet on toll-like receptor 4/nuclear factor-kappa B/nod-like receptor protein 3 signaling pathway in mice with atherosclerosis induced by high-fat diet
CONCLUSION: JZXB has inhibitory effect on atherosclerosis in mice, and its mechanism may be through regulating the TLR4/NF-κB/NLRP3 signaling pathway and reducing the inflammatory response, so as to play a role in inhibiting atherosclerosis.PMID:38213243 | PMC:PMC10774719 | DOI:10.19852/j.cnki.jtcm.20231121.002 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 12, 2024 Category: Complementary Medicine Authors: Liu Huihui Feng Jun Liu Jianhe Cheng Choufu H U Guoheng Source Type: research
Taohong Siwu decoction ameliorates atherosclerosis in rats possibly through toll-like receptor 4/myeloid differentiation primary response protein 88/nuclear factor- κB signal pathway
CONCLUSIONS: TSD can ameliorate atherosclerosis in rats, and the underlying mechanism is supposed be related to the suppression of inflammatory response by regulating TLR4/MyD88/NF-κB signal pathway.PMID:38213245 | PMC:PMC10774721 | DOI:10.19852/j.cnki.jtcm.20231215.003 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 12, 2024 Category: Complementary Medicine Authors: Chang Fengjin Zhou Peng L I Guoying Zhang Weizhi Zhang Yanyan Peng Daiyin Chen Guangliang Source Type: research
Efficacy of Jiangzhi Xiaoban tablet on toll-like receptor 4/nuclear factor-kappa B/nod-like receptor protein 3 signaling pathway in mice with atherosclerosis induced by high-fat diet
CONCLUSION: JZXB has inhibitory effect on atherosclerosis in mice, and its mechanism may be through regulating the TLR4/NF-κB/NLRP3 signaling pathway and reducing the inflammatory response, so as to play a role in inhibiting atherosclerosis.PMID:38213243 | PMC:PMC10774719 | DOI:10.19852/j.cnki.jtcm.20231121.002 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 12, 2024 Category: Complementary Medicine Authors: Liu Huihui Feng Jun Liu Jianhe Cheng Choufu H U Guoheng Source Type: research
Taohong Siwu decoction ameliorates atherosclerosis in rats possibly through toll-like receptor 4/myeloid differentiation primary response protein 88/nuclear factor- κB signal pathway
CONCLUSIONS: TSD can ameliorate atherosclerosis in rats, and the underlying mechanism is supposed be related to the suppression of inflammatory response by regulating TLR4/MyD88/NF-κB signal pathway.PMID:38213245 | PMC:PMC10774721 | DOI:10.19852/j.cnki.jtcm.20231215.003 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 12, 2024 Category: Complementary Medicine Authors: Chang Fengjin Zhou Peng L I Guoying Zhang Weizhi Zhang Yanyan Peng Daiyin Chen Guangliang Source Type: research
Efficacy of Jiangzhi Xiaoban tablet on toll-like receptor 4/nuclear factor-kappa B/nod-like receptor protein 3 signaling pathway in mice with atherosclerosis induced by high-fat diet
CONCLUSION: JZXB has inhibitory effect on atherosclerosis in mice, and its mechanism may be through regulating the TLR4/NF-κB/NLRP3 signaling pathway and reducing the inflammatory response, so as to play a role in inhibiting atherosclerosis.PMID:38213243 | PMC:PMC10774719 | DOI:10.19852/j.cnki.jtcm.20231121.002 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 12, 2024 Category: Complementary Medicine Authors: Liu Huihui Feng Jun Liu Jianhe Cheng Choufu H U Guoheng Source Type: research
Taohong Siwu decoction ameliorates atherosclerosis in rats possibly through toll-like receptor 4/myeloid differentiation primary response protein 88/nuclear factor- κB signal pathway
CONCLUSIONS: TSD can ameliorate atherosclerosis in rats, and the underlying mechanism is supposed be related to the suppression of inflammatory response by regulating TLR4/MyD88/NF-κB signal pathway.PMID:38213245 | PMC:PMC10774721 | DOI:10.19852/j.cnki.jtcm.20231215.003 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 12, 2024 Category: Complementary Medicine Authors: Chang Fengjin Zhou Peng L I Guoying Zhang Weizhi Zhang Yanyan Peng Daiyin Chen Guangliang Source Type: research
Efficacy of Jiangzhi Xiaoban tablet on toll-like receptor 4/nuclear factor-kappa B/nod-like receptor protein 3 signaling pathway in mice with atherosclerosis induced by high-fat diet
CONCLUSION: JZXB has inhibitory effect on atherosclerosis in mice, and its mechanism may be through regulating the TLR4/NF-κB/NLRP3 signaling pathway and reducing the inflammatory response, so as to play a role in inhibiting atherosclerosis.PMID:38213243 | PMC:PMC10774719 | DOI:10.19852/j.cnki.jtcm.20231121.002 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - January 12, 2024 Category: Complementary Medicine Authors: Liu Huihui Feng Jun Liu Jianhe Cheng Choufu H U Guoheng Source Type: research
Genetic Determinants of Response to Statins in Cardiovascular Diseases
Curr Cardiol Rev. 2024 Jan 9. doi: 10.2174/011573403X267793231220114042. Online ahead of print.ABSTRACTDespite extensive efforts to identify patients with cardiovascular disease (CVD) who could most benefit from the treatment approach, patients vary in their benefit from therapy and propensity for adverse drug events. Genetic variability in individual responses to drugs (pharmacogenetics) is considered an essential determinant in responding to a drug. Thus, understanding these pharmacogenomic relationships has led to a substantial focus on mechanisms of disease and drug response. In turn, understanding the genomic and mole...
Source: Current Cardiology Reviews - January 11, 2024 Category: Cardiology Authors: Ghazaleh Ghorbannezhad Shima Mehrabadi Negar Golampour-Shamkani Amirhossein Barjasteh Poorya Etesamizadeh Mohammad Tayyebi Majid Khazaei Seyed Mahdi Hassanian Gordon A Ferns Amir Avan Source Type: research
Cholinesterase inhibitors-associated torsade de pointes/QT prolongation: a real-world pharmacovigilance study
Conclusion: The signals of TdP/QT prolongation related to ChEIs were strong and stable. It is necessary to be vigilant about the TdP/QT prolongation of various ChEIs, especially in elderly women, the initial stage after taking ChEIs, and when ChEIs combining with drugs that could prolong the QT interval. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 11, 2024 Category: Drugs & Pharmacology Source Type: research
The Effect of Original Russian Neurotropic Drugs on Organic Anion Transporting Polypeptides OATP1B1 and OATP1B3
In experiments on HepG2 cells, we studied the effect of the original domestic neurotropic drugs omberacetam, fabomotizole, and ethylmethylhydroxypyridine succinate (EMHPS) (1-500 μM) on the activity and content of organic anion transporting polypeptides OATP1B1 and OATP1B3. It was shown that omberacetam (500 μM) increased the content of OATP1B1 and OATP1B3, fabomotizole did not affect the level of both transporters, and EMHPS (500 μM) increased the content of OATP1B1 comp ared to the control and did not affect the level of OATP1B3. The tested substances also reduced the OATP1B1/OATP1B3 ratio, as evidenced by a decrease ...
Source: Bulletin of Experimental Biology and Medicine - January 10, 2024 Category: Biology Source Type: research
Effect of atorvastatin calcium plus clopidogrel in the treatment of patients with transient ischemic attacks and its effect on blood lipids and platelets
. (Source: International Journal of Neuroscience)
Source: International Journal of Neuroscience - January 10, 2024 Category: Neuroscience Authors: Maocheng BianFei ZhongJian WanEmergency and Critical Care Medicine, Shanghai Pudong New Area People ’s Hospital, Shanghai, China Source Type: research
Low-Dose Atorvastatin has Promoting Effect on Melanoma Tumor Growth and Angiogenesis in Mouse Model
CONCLUSION: Atorvastatin, at low therapeutic concentrations, has been observed to stimulate tumor growth and exhibit pro-angiogenic effects. Therefore, it is advised to exercise caution and recommend clinically relevant doses of statins to patients with cancer.PMID:38192896 | PMC:PMC10772795 | DOI:10.4103/abr.abr_120_22 (Source: Cancer Control)
Source: Cancer Control - January 9, 2024 Category: Cancer & Oncology Authors: Golnaz Vaseghi Elmira Ahmadzadeh Hajar Naji Esfahani Majed Bahri Najafi Nazgol Esmailian Shaghayegh Haghjooy Javanmard Source Type: research
