Atorvastatin ‐induced intracerebral hemorrhage is inhibited by berberine in zebrafish
In this study, we aimed to investigate the protective action and mechanisms of berberine (BBR) against ATV-induced brain hemorrhage. We established an ICH model in zebrafish induced by ATV (2 μM) and demonstrated the effects of BBR (10, 50, and 100 μM) on ICH via protecting the vascular network using hemocyte staining and three transgenic zebrafish. BBR was found to reduce brain inflammation and locomotion injury in ICH-zebrafish. Mechanism research showed that ATV increased the l evels of VE-cadherin and occludin proteins but disturbed their localization at the cell membrane by abnormal phosphorylation, which decre...
Source: Journal of Applied Toxicology - April 20, 2024 Category: Toxicology Authors: Xin ‐Yan Liu,
Bo Chen,
Rui Zhang,
Miao‐Qing Zhang,
Yuan‐Yuan Ma,
Ying Han,
Jian‐Dong Jiang,
Jing‐Pu Zhang Tags: RESEARCH ARTICLE Source Type: research
Extract of Gualou-Xiebai Herb Pair Improves Lipid Metabolism Disorders by Enhancing the Reverse Cholesterol Transport in Atherosclerosis Mice
CONCLUSION: In summary, our results suggested that GXE improved lipid metabolism disorders by enhancing RCT, providing a scientific basis for the clinical use of GXE in AS treatment.PMID:38629368 | DOI:10.2174/0115672026308438240405055719 (Source: Cell Research)
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Yarong Liu Tian Wang Lidan Ding Zhenglong Li Yexiang Zhang Min Dai Hongfei Wu Source Type: research
Extract of Gualou-Xiebai Herb Pair Improves Lipid Metabolism Disorders by Enhancing the Reverse Cholesterol Transport in Atherosclerosis Mice
CONCLUSION: In summary, our results suggested that GXE improved lipid metabolism disorders by enhancing RCT, providing a scientific basis for the clinical use of GXE in AS treatment.PMID:38629368 | DOI:10.2174/0115672026308438240405055719 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Yarong Liu Tian Wang Lidan Ding Zhenglong Li Yexiang Zhang Min Dai Hongfei Wu Source Type: research
Pharmacokinetic interaction between regorafenib and atorvastatin in rats
CONCLUSIONS: This animal model study showed a significant pharmacokinetic interaction between regorafenib and atorvastatin. While this interaction may be clinically significant, this needs to be confirmed in clinical trials involving cancer patients.PMID:38632186 | DOI:10.1007/s43440-024-00570-z (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 17, 2024 Category: Drugs & Pharmacology Authors: Danuta Szkutnik-Fiedler Edyta Sza łek Filip Otto Andrzej Czyrski Marta Kara źniewicz-Łada Anna Wolc Edmund Grze śkowiak Konrad Lewandowski Agnieszka Karbownik Source Type: research
Extract of Gualou-Xiebai Herb Pair Improves Lipid Metabolism Disorders by Enhancing the Reverse Cholesterol Transport in Atherosclerosis Mice
CONCLUSION: In summary, our results suggested that GXE improved lipid metabolism disorders by enhancing RCT, providing a scientific basis for the clinical use of GXE in AS treatment.PMID:38629368 | DOI:10.2174/0115672026308438240405055719 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - April 17, 2024 Category: Neurology Authors: Yarong Liu Tian Wang Lidan Ding Zhenglong Li Yexiang Zhang Min Dai Hongfei Wu Source Type: research
Extract of Gualou-Xiebai Herb Pair Improves Lipid Metabolism Disorders by Enhancing the Reverse Cholesterol Transport in Atherosclerosis Mice
CONCLUSION: In summary, our results suggested that GXE improved lipid metabolism disorders by enhancing RCT, providing a scientific basis for the clinical use of GXE in AS treatment.PMID:38629368 | DOI:10.2174/0115672026308438240405055719 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Yarong Liu Tian Wang Lidan Ding Zhenglong Li Yexiang Zhang Min Dai Hongfei Wu Source Type: research
Pharmacokinetic interaction between regorafenib and atorvastatin in rats
CONCLUSIONS: This animal model study showed a significant pharmacokinetic interaction between regorafenib and atorvastatin. While this interaction may be clinically significant, this needs to be confirmed in clinical trials involving cancer patients.PMID:38632186 | DOI:10.1007/s43440-024-00570-z (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 17, 2024 Category: Drugs & Pharmacology Authors: Danuta Szkutnik-Fiedler Edyta Sza łek Filip Otto Andrzej Czyrski Marta Kara źniewicz-Łada Anna Wolc Edmund Grze śkowiak Konrad Lewandowski Agnieszka Karbownik Source Type: research
Pharmacokinetic interaction between regorafenib and atorvastatin in rats
CONCLUSIONS: This animal model study showed a significant pharmacokinetic interaction between regorafenib and atorvastatin. While this interaction may be clinically significant, this needs to be confirmed in clinical trials involving cancer patients.PMID:38632186 | DOI:10.1007/s43440-024-00570-z (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 17, 2024 Category: Drugs & Pharmacology Authors: Danuta Szkutnik-Fiedler Edyta Sza łek Filip Otto Andrzej Czyrski Marta Kara źniewicz-Łada Anna Wolc Edmund Grze śkowiak Konrad Lewandowski Agnieszka Karbownik Source Type: research
The pharmacokinetics of single-dose oral atorvastatin and its metabolites support therapeutic use in cockatiels (Nymphicus hollandicus)
Am J Vet Res. 2024 Apr 19:1-7. doi: 10.2460/ajvr.24.03.0068. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the plasma concentrations and determine the pharmacokinetic parameters of atorvastatin and its primary active metabolites (para- and orthohydroxyatorvastatin) after administration of a single oral dose in cockatiels (Nymphicus hollandicus).ANIMALS: 14 adult cockatiels (7 male, 7 female) around 2 years of age.METHODS: A compounded oral suspension of atorvastatin 10 mg/mL made with an oral suspending agent and an oral sweetener was administered via oral gavage at 20 mg/kg to each bird. Blood samples were collecte...
Source: American Journal of Veterinary Research - April 16, 2024 Category: Veterinary Research Authors: Michaela Mitchell David Sanchez-Migallon Guzman Heather Knych Hugues Beaufr ère Source Type: research
The pharmacokinetics of single-dose oral atorvastatin and its metabolites support therapeutic use in cockatiels (Nymphicus hollandicus)
Am J Vet Res. 2024 Apr 19:1-7. doi: 10.2460/ajvr.24.03.0068. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the plasma concentrations and determine the pharmacokinetic parameters of atorvastatin and its primary active metabolites (para- and orthohydroxyatorvastatin) after administration of a single oral dose in cockatiels (Nymphicus hollandicus).ANIMALS: 14 adult cockatiels (7 male, 7 female) around 2 years of age.METHODS: A compounded oral suspension of atorvastatin 10 mg/mL made with an oral suspending agent and an oral sweetener was administered via oral gavage at 20 mg/kg to each bird. Blood samples were collecte...
Source: Atherosclerosis - April 16, 2024 Category: Cardiology Authors: Michaela Mitchell David Sanchez-Migallon Guzman Heather Knych Hugues Beaufr ère Source Type: research
The pharmacokinetics of single-dose oral atorvastatin and its metabolites support therapeutic use in cockatiels (Nymphicus hollandicus)
Am J Vet Res. 2024 Apr 19:1-7. doi: 10.2460/ajvr.24.03.0068. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the plasma concentrations and determine the pharmacokinetic parameters of atorvastatin and its primary active metabolites (para- and orthohydroxyatorvastatin) after administration of a single oral dose in cockatiels (Nymphicus hollandicus).ANIMALS: 14 adult cockatiels (7 male, 7 female) around 2 years of age.METHODS: A compounded oral suspension of atorvastatin 10 mg/mL made with an oral suspending agent and an oral sweetener was administered via oral gavage at 20 mg/kg to each bird. Blood samples were collecte...
Source: American Journal of Veterinary Research - April 16, 2024 Category: Veterinary Research Authors: Michaela Mitchell David Sanchez-Migallon Guzman Heather Knych Hugues Beaufr ère Source Type: research
Impact of LDLR polymorphisms on lipid levels and atorvastatin ’s efficacy in a northern Chinese adult Han cohort with dyslipidemia
Dyslipidemia, a significant risk factor for atherosclerotic cardiovascular disease (ASCVD), is influenced by genetic variations, particularly those in the low-density lipoprotein receptor (LDLR) gene. This stu... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 14, 2024 Category: Lipidology Authors: Hong-Liang Zhao, Yang You, Yan Tian, Luyan Wang, Yongqiang An, Guoqiang Zhang, Chang Shu, Mingxin Yu, Yihua Zhu, Qian Li, Yanwei Zhang, Ningling Sun, Songnian Hu and Gang Liu Tags: Research Source Type: research
The maximum dose of atorvastatin and simvastatin as well as rosuvastatin should be restricted in East Asians
Hong Kong Med J. 2024 Apr 12. doi: 10.12809/hkmj2311348. Online ahead of print.NO ABSTRACTPMID:38605565 | DOI:10.12809/hkmj2311348 (Source: Hong Kong Med J)
Source: Hong Kong Med J - April 12, 2024 Category: General Medicine Authors: B Tomlinson E Chow Source Type: research
The maximum dose of atorvastatin and simvastatin as well as rosuvastatin should be restricted in East Asians
Hong Kong Med J. 2024 Apr 12. doi: 10.12809/hkmj2311348. Online ahead of print.NO ABSTRACTPMID:38605565 | DOI:10.12809/hkmj2311348 (Source: Hong Kong Medical Journal)
Source: Hong Kong Medical Journal - April 12, 2024 Category: General Medicine Authors: B Tomlinson E Chow Source Type: research
The maximum dose of atorvastatin and simvastatin as well as rosuvastatin should be restricted in East Asians
Hong Kong Med J. 2024 Apr 12. doi: 10.12809/hkmj2311348. Online ahead of print.NO ABSTRACTPMID:38605565 | DOI:10.12809/hkmj2311348 (Source: Hong Kong Med J)
Source: Hong Kong Med J - April 12, 2024 Category: General Medicine Authors: B Tomlinson E Chow Source Type: research
