Early statin exposure influences cardiac and skeletal development with implications for ion channel transcriptomes in zebrafish
In this study, we investigated the developmental effects of two widely used statins, atorvastatin (ATO) and pravastatin (PRA), on zebrafish offspring. For ATO, we administered doses classified as low (1 μM), medium (5 μM), and high (10 μM), while for PRA, the corresponding concentrations were set at low (18 μM), medium (180 μM), and high (270 μM). Our results showed significant reductions in birth and hatching rates, along with decreased body length in offspring at all ATO concentrations and medium to high PRA concentrations. A notable increase in malformation rates, especially in the spine and heart, was observed across all ATO treatments and in medium and high PRA groups. Additionally, we observed reduced heart contraction rates, decreased heart size, lower bone volumes, and diminished expression of mRNA osteogenic markers. Elevated venous sinus-artery bulb (SV-BA) ratios, increased thoracic area, and abnormal cartilage development were also prominent in all ATO-treated groups. Transcriptome analysis revealed alterations in genes predominantly associated with ion channels. These findings provide insights into the potential impacts of specific concentrations of statins on offspring development and highlight potential gene interactions with statins.PMID:38522713 | DOI:10.1016/j.cbpc.2024.109905
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - Category: Biochemistry Authors: Ying Zhao Hou-Zhi Yang Huinan Li Shuang Liang Meng Wang Chun-Di Li Donghai Zhuo Feifei Fan Miao Guo Xinxin Lv Lingzhu Zhang Xu Chen Shan-Shan Li Xin Jin Source Type: research
More News: Atorvastatin Calcium | Biochemistry | Cardiology | Cholesterol | Drugs & Pharmacology | Genetics | Heart | Lipitor | Men | Physiology | Pravastatin | Statin Therapy | Study | Toxicology | Zivast