Bone mineral density, turnover, and microarchitecture assessed by second-generation high-resolution peripheral quantitative computed tomography in patients with Sheehan ’s syndrome
ConclusionLow areal BMD (aBMD) is highly prevalent in SS as compared to age- and BMI-matched controls. However, there were no significant differences in bone microarchitectural measurements, except for tibial cortical vBMD, which was lower in adequately treated SS patients. (Source: Osteoporosis International)
Source: Osteoporosis International - April 19, 2024 Category: Orthopaedics Source Type: research

One sip of water with LT-4 supplementation —a key to euthyroidism in Hashimoto’s thyroiditis
ConclusionsThe reduction of water ingestion to a maximum of two sips, which is<50  mL, combined with LT-4 supplementation helps to achieve euthyroidism in HT. In addition, it reduces the L-T4 medication dosage needed to lower TSH serum levels and decreases TPO antibodies in HT. (Source: Endocrine)
Source: Endocrine - April 18, 2024 Category: Endocrinology Source Type: research

Ameliorative effect of ferulic acid on thyroid dysfunction against propyl-thiouracil induced hypothyroid rats
ConclusionIn conclusion, FA treatment showed a protective effect against hypothyroidism by stimulating the thyroid hormones through the activation of thyroid peroxidase enzyme and improving thyroid function. In addition, FA diminished the increase in lipids, liver and kidney markers, oxidative stress and inflammation.Graphical Abstract (Source: Endocrine)
Source: Endocrine - April 18, 2024 Category: Endocrinology Source Type: research

The effect of low-level laser therapy on the oxidative stress level and quality of life in patients with Hashimoto's thyroiditis
This study aimed to examine the effects of low-level laser therapy (LLLT) combined with levothyroxine replacement therapy on thyroid function, oxidative stress (OS), and quality of life in patients with Hashimoto's thyroiditis (HT). Forty-six patients diagnosed with HT were randomized to receive active LLLT (n = 23) and sham LLLT (n = 23) twice a week for three weeks. Clinical and laboratory evaluations of the participants were performed before treatment and three months after treatment. Biochemical parameters were taken from the patient file requested by the physician as a routine examination. Malondialdehyde and nitricox...
Source: Free Radical Research - April 17, 2024 Category: Research Authors: S ümeyye Tunç Şükriye Leyla Altuntaş Murat Atmaca Çağrı Çakıcı T ürkan Yiğitbaşı Yeong-Cheng Liou Wei-An Chang Source Type: research

Using haematological indices to predict impaired liver function in DTC patients
CONCLUSION: Our results suggest that PC and ALC are independent predictors of hypo-related liver injury. Our study is the first to suggest that haematological indices can be used for predicting the development and progression of hypo-related liver disorders.PMID:38629813 | DOI:10.1967/s002449912700 (Source: Hellenic Journal of Nuclear Medicine)
Source: Hellenic Journal of Nuclear Medicine - April 17, 2024 Category: Nuclear Medicine Authors: Yanli Zhou Hong Chai Source Type: research

Evaluation of the therapeutic efficacy of different doses of LT4 in pregnant women with high-normal TSH levels and TPOAb positivity in the first half of pregnancy
The objective was to investigate the efficacy of different doses of levothyroxine therapy among pregnant women exhibiting high-normal thyroid stimulating hormone levels and positive thyroid peroxidase antibodi... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 10, 2024 Category: Lipidology Authors: Xin Tian, Yajuan Xu, Yanjie Ban, Jingjing Li, Lin Hu, Dong Liu, Lulu Hu, Zongzong Sun, Miao Zhang, Chenchen Zhang, Yixin Wang and Pengkun Lin Tags: Research Source Type: research

Effects of Levothyroxine Treatment on Fertility and Pregnancy Outcomes in Subclinical Hypothyroidism: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Thyroid ®,Volume 34, Issue 4, Page 519-530, April 2024. (Source: Thyroid)
Source: Thyroid - April 4, 2024 Category: Endocrinology Authors: Akiko Sankoda Hitomi Suzuki Misa Imaizumi Ai Yoshihara Sakiko Kobayashi Miyuki Katai Katsuhiko Hamada Yoh Hidaka Aya Yoshihara Hannah Nakamura Sumihisa Kubota Maiko Kakita-Kobayashi Akira Iwase Takashi Sugiyama Erika Ota Naoko Arata Source Type: research

Levothyroxine-sodium
(Source: Reactions Weekly)
Source: Reactions Weekly - April 1, 2024 Category: Drugs & Pharmacology Source Type: research

Increased risk of diabetes mellitus and hyperlipidemia in patients with differentiated thyroid cancer
CONCLUSIONS: Patients with DTC had an increased risk of CMD, especially DM and hyperlipidemia, but a low risk of CMD mortality. Special attention to metabolic diseases is required in the long-term follow-up of patients with DTC.PMID:38536878 | DOI:10.1093/ejendo/lvae026 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 27, 2024 Category: Endocrinology Authors: Hwa Young Ahn Jooyoung Lee Jinmo Kang Eun Kyung Lee Source Type: research

Increased risk of diabetes mellitus and hyperlipidemia in patients with differentiated thyroid cancer
CONCLUSIONS: Patients with DTC had an increased risk of CMD, especially DM and hyperlipidemia, but a low risk of CMD mortality. Special attention to metabolic diseases is required in the long-term follow-up of patients with DTC.PMID:38536878 | DOI:10.1093/ejendo/lvae026 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 27, 2024 Category: Endocrinology Authors: Hwa Young Ahn Jooyoung Lee Jinmo Kang Eun Kyung Lee Source Type: research

Association of pharmacogenomic, clinical and behavioural factors with oral levothyroxine (LT-4) dose of hypothyroid patients in Sri Lanka: a matched case control study
Hypothyroidism is a common endocrine disorder that exerts a substantial influence on people all over the world. Levothyroxine (LT-4) is the drug of choice for the treatment of hypothyroidism and the starting o... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - March 27, 2024 Category: Genetics & Stem Cells Authors: S. S. Dalugodage, Gayan Bowatte, Charles Antonypillai, S. Rajapakse and T. M. I. U. K. Tennakoon Tags: Study Protocol Source Type: research

Potential risks and benefits of desiccated thyroid extract for the treatment of hypothyroidism: A systematic review
CONCLUSIONS: Most studies of DTE treatment are hampered by an inferior design, and data on long-term effects and side effects are lacking. Two RCTs could not demonstrate any difference in QoL or symptom scores when comparing DTE with other thyroid hormone substitutions. Future trials of DTE in patients with hypothyroidism should be based on adequate study designs, validated measures of QoL, patients with reduced QoL, and the assessment of biomarkers reflecting long-term adverse effects.PMID:38526391 | DOI:10.1089/thy.2023.0649 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - March 25, 2024 Category: Endocrinology Authors: Kamilla Ryom Riis Camilla B øgelund Larsen Steen Joop Bonnema Source Type: research