Pharyngeal mucosal closure in total laryngectomy: comparison between vertical and T-shaped closure
CONCLUSIONS: Although complicationswere lower in the T-shaped closure group, we could not establish the superiority of either technique.PMID:38502946 | DOI:10.24875/CIRU.22000324 (Source: Cirugia y Cirujanos)
Source: Cirugia y Cirujanos - March 19, 2024 Category: Surgery Authors: Adolfo Montemayor-Alatorre Ruth P Serna-Vazquez Karla M Santos-Santillana Josefina A Morales-Del Ángel Jos é R Córtes-Ponce Jos é L Treviño-González Source Type: research
Pharyngeal mucosal closure in total laryngectomy: comparison between vertical and T-shaped closure
CONCLUSIONS: Although complicationswere lower in the T-shaped closure group, we could not establish the superiority of either technique.PMID:38502946 | DOI:10.24875/CIRU.22000324 (Source: Cirugia y Cirujanos)
Source: Cirugia y Cirujanos - March 19, 2024 Category: Surgery Authors: Adolfo Montemayor-Alatorre Ruth P Serna-Vazquez Karla M Santos-Santillana Josefina A Morales-Del Ángel Jos é R Córtes-Ponce Jos é L Treviño-González Source Type: research
The Effect of Free Flap Surgery for Oral Cancer on Laryngeal Grade and Intubation Difficulty
The purpose of this study was to evaluate the change in laryngeal grade and intubation difficulty at subsequent surgery in patients with prior free flap reconstruction for oral cancer. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - March 19, 2024 Category: ENT & OMF Authors: Brian Rezel Carr, Timothy Wayne Neal, Robert Hermann, David Schwitzer, Jonathan Jelmini, Roderick Y. Kim Source Type: research
Patterns of recurrence in HNSCC patients treated definitively with upfront surgery, chemoradiation
CONCLUSION: Locoregional control and RFS benefit was observed in surgically treated p16 negative LA-OPSCC patients. Locoregional recurrence is the main reason of treatment failure in LA-HNSCC, occurring commonly within the first 2 years post-treatment, regardless of treatment option.PMID:38498191 | DOI:10.1007/s00405-024-08556-6 (Source: Cancer Control)
Source: Cancer Control - March 18, 2024 Category: Cancer & Oncology Authors: Pei Yuan Fong Thomas Kwok Seng Loh Liang Shen Donovan Kum Chuen Eu Chwee Ming Lim Source Type: research
Laryngeal Cancer Presenting as an Anterior Glottic Web
Ear Nose Throat J. 2024 Mar 17:1455613241233751. doi: 10.1177/01455613241233751. Online ahead of print.NO ABSTRACTPMID:38494748 | DOI:10.1177/01455613241233751 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - March 18, 2024 Category: ENT & OMF Authors: Razmig Garabet Lauren E Melley Omar Ramadan Robert T Sataloff Source Type: research
Cancers, Vol. 16, Pages 1180: PIP4K2B Protein Regulation by NSD1 in HPV-Negative Head and Neck Squamous Cell Carcinoma
In conclusion, our findings implicate PIP4K2B as a novel NSD1-dependent protein in HNSCC, suggesting its potential significance for laryngeal cancer cell survival. This insight contributes to our understanding of the molecular landscape in HNSCC and establishes PIP4KB as a promising target for drug development. (Source: Cancers)
Source: Cancers - March 17, 2024 Category: Cancer & Oncology Authors: Iuliia Topchu Igor Bychkov Ekaterina Roshchina Petr Makhov Yanis Boumber Tags: Article Source Type: research
Salivary gland-type cancers: cross-organ demographics of a rare cancer
ConclusionsThis cross-organ study highlights the clinical significance of SGTCs, underscoring the need for developing novel therapies for this rare disease entity. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 16, 2024 Category: Cancer & Oncology Source Type: research
Short-term outcomes of robot-assisted versus conventional minimally invasive esophagectomy for esophageal cancer: a systematic review and meta-analysis of 18,187 patients
AbstractThe role of robotic surgery in the curative-intent treatment of esophageal cancer patients is yet to be defined. To compare short-term outcomes between conventional minimally invasive (cMIE) and robot-assisted minimally invasive esophagectomy (RAMIE) in esophageal cancer patients. PubMed, Web of Science and Cochrane Library were systematically searched. The included studies compared short-term outcomes between cMIE and RAMIE. Individual risk of bias was calculated using the MINORS and RoB2 scales. There were no statistically significant differences between RAMIE and cMIE regarding conversion to open procedure, mean...
Source: Journal of Robotic Surgery - March 16, 2024 Category: Surgery Source Type: research
Proton beam radiotherapy head and neck cancer study design and endpoints
We thank Friborg et al for sharing Denmark ’s important contributions to the evidence base for proton beam therapy in head and neck cancer patients [1]. In the Danish model, head and neck squamous cell cancer (SCC) in all sub-sites excluding early T1-2N0M0 larynx were included. Patients are double planned with comparisons made between prot on-photon dosimetry and a 5% superiority in the normal tissue complication probability (NTCP) model estimated risk for xerostomia and dysphagia is used to guide randomisation into DAHANCA35. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - March 15, 2024 Category: Radiology Authors: Cheng S. Boon, Shanmugasundaram Ramkumar, Ian S. Boon Tags: Letter to the Editor Source Type: research
Deep Learning-Based Prognostic Prediction for Early Stage Laryngeal Cancer Patients Post-Radiotherapy: Utilizing 3D CBCT and EMR Data
Radiation therapy is a predominant treatment method for early-stage laryngeal cancer patients. The primary objective of this study is to predict the prognosis of recurrence in this specific patient group. Our study cohort comprises patients with stages 0-2, who have undergone radiation therapy with a curative intent rather than for palliative care. In this research, we endeavor to introduce a deep learning-based survival analysis model that harnesses data from multiple modalities obtained during radiation therapy. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: J.H. Lim, J. Heo, O.K. Noh Tags: 150 Source Type: research
High Expression of Sphingosine-1-Phosphate Phosphatase 1 Inversely Correlates with p16 Expression and Is Associated with Poor Prognosis in Laryngeal Cancer Patients
While high protein expression of p16 is associated with better clinical outcomes and a less aggressive phenotype in larynx cancers, the molecular mechanisms underlying the association of p16 over-expression and improved survival in larynx cancer remain to be defined. We hypothesized that p16 protein expression levels are associated with distinct cellular pathways and clinical outcomes in larynx cancer. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: H. Nguyen, D. Gaykalova, R. Mehra, A.C. Shetty, M.E. Witek Tags: 224 Source Type: research
Voice Related Quality of Life (qol) in Volumetric Modulated Arc Therapy (vmat) for Non-laryngeal Head and Neck Malignancies
To assess the Voice Quality of life in non-laryngeal carcinoma who undergo VMAT. Primary objective:1. Subjective assessment of the Voice related QOL in patients undergoing radiation therapy with VMAT technique for non-laryngeal head and neck malignancy using Voice Handicap Index.2. Objective assessment of the Voice related QOL in patients undergoing radiation therapy with VMAT technique for non -laryngeal head and neck malignancy using Video-stroboscopy and voice analysis.Secondary objective: 1. To assess the correlation between Voice related QOL and dose-volume parameters of radiation therapy. (Source: Internati...
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: S.K. Ramesh babu, R. Isiah, J. Sargunaraj, R. Thejes, M. Mathew, S. Siddique, S.P. Pavamani, S. John, B.K. Sasidharan, T.B. Peace, S.S. Mathews, R.R.A. Mathews, R. K Tags: 206 Source Type: research
Association of Radiation Dose to Pharynx with Long-term Quality of Life in Patients with Head and Neck Cancer
Radiation therapy (RT) is often the primary curative treatment modality for head and neck cancer (HNC). Patients receiving definitive RT for HNC are at high risk for long-term toxicity, including dry mouth, swallowing difficulties, and speech difficulties. Previous studies have suggested structure sparing during RT planning may reduce treatment toxicity as a way to mitigate these long-term effects. The purpose of this study was to evaluate the association of RT dose to the pharynx, larynx, and esophagus with long-term patient-reported quality of life (QOL) in the domains of xerostomia, dysphagia, and dysarthria. (Source: I...
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: M.A. Azam, A. Jhuma, H. Joseph, A.J. Iovoli, A.K. Singh Tags: 199 Source Type: research
Oridonin inhibited epithelial-mesenchymal transition of laryngeal carcinoma by positively regulating LKB1/AMPK signaling
In conclusion, our study revealed that oridonin could remarkably reverse the epithelial-mesenchymal transition of laryngeal carcinoma by positively regulating LKB1/AMPK signaling pathway, which suggested that oridonin may be a potential candidate for the treatment of laryngeal carcinoma in the future.PMID:38464825 | PMC:PMC10920846 | DOI:10.7150/ijms.92182 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - March 11, 2024 Category: Biomedical Science Authors: Bo Kou Yuhan Shi Zhaoyue Zhou Yanning Yun Qun Wu Jinsong Zhou Wei Liu Source Type: research
A Genome Wide CRISPR Profiling Approach Identifies Mechanisms of Cisplatin Resistance in Head and Neck Squamous Cell Carcinoma
Conclusions Collectively, our study validates a genome-wide CRISPR/Cas9 approach for the discovery of resistance mechanisms in HNSCC, adds to the growing evidence that NOTCH1 status should be evaluated as a biomarker of cisplatin response and provides a framework for future work aimed at overcoming cisplatin resistance.PMID:38464196 | PMC:PMC10925415 | DOI:10.21203/rs.3.rs-3922565/v1 (Source: Cell Research)
Source: Cell Research - March 11, 2024 Category: Cytology Authors: Megan Ludwig Andrew Birkeland Joshua Smith Elizabeth Gensterblum-Miller JIngyi Zhai Aditi Kulkarni Hui Jiang Chad Brenner Source Type: research
