Radiation Dose Sensitivity of Subregions of the Larynx to Patient-Reported Swallowing Outcomes
CONCLUSIONS: These results show the relatively increased sensitivity of the epiglottis compared with the rest of the larynx when considering patient-reported decrements in quality-of-life swallowing score and support both the inclusion of the epiglottis in standard larynx contours and the assessment of the epiglottis dose during plan evaluation. Our data suggest that keeping the mean and max doses to the epiglottis <20 to 37 Gy and <53 to 60 Gy, respectively, will reduce swallowing difficulties.PMID:38550375 | PMC:PMC10973584 | DOI:10.1016/j.adro.2024.101458 (Source: Adv Data)
Source: Adv Data - March 29, 2024 Category: Epidemiology Authors: Mark D Pepin Stephanie Anaya Yolanda I Garces Emily Hosfield Scott C Lester Daniel J Ma Daniel W Mundy Michelle A Neben-Wittich David M Routman Catherine Shonley Robert L Foote Satomi Shiraishi Source Type: research
Radiation Dose Sensitivity of Subregions of the Larynx to Patient-Reported Swallowing Outcomes
CONCLUSIONS: These results show the relatively increased sensitivity of the epiglottis compared with the rest of the larynx when considering patient-reported decrements in quality-of-life swallowing score and support both the inclusion of the epiglottis in standard larynx contours and the assessment of the epiglottis dose during plan evaluation. Our data suggest that keeping the mean and max doses to the epiglottis <20 to 37 Gy and <53 to 60 Gy, respectively, will reduce swallowing difficulties.PMID:38550375 | PMC:PMC10973584 | DOI:10.1016/j.adro.2024.101458 (Source: Adv Data)
Source: Adv Data - March 29, 2024 Category: Epidemiology Authors: Mark D Pepin Stephanie Anaya Yolanda I Garces Emily Hosfield Scott C Lester Daniel J Ma Daniel W Mundy Michelle A Neben-Wittich David M Routman Catherine Shonley Robert L Foote Satomi Shiraishi Source Type: research
IncRNA AC004943.2 regulates miR-135a-5p and PTK2/P13K axis to promote laryngeal squamous cell carcinoma progression
J Cell Commun Signal. 2024 Feb 9;18(1):e12016. doi: 10.1002/ccs3.12016. eCollection 2024 Mar.ABSTRACTLong noncoding RNAs (lncRNAs) are involved in regulatory processes in laryngeal squamous cell carcinoma (LSCC) at posttranscriptional epigenetic modification level. Yet, the function and underlying mechanism behind lncRNA AC004943.2 in LSCC is still obscure. Therefore, the potential role of AC004943.2 in LSCC progression was investigated. The expression of gene or protein was tested by real-time quantitative polymerase chain reaction and western blot. MTT, colony formation, wound healing, and transwell experiments were appl...
Source: Journal of Cell Communication and Signaling - March 28, 2024 Category: Molecular Biology Authors: Xiaowen Zhu Wenming Dong Meijia Zhang Source Type: research
IncRNA AC004943.2 regulates miR-135a-5p and PTK2/P13K axis to promote laryngeal squamous cell carcinoma progression
J Cell Commun Signal. 2024 Feb 9;18(1):e12016. doi: 10.1002/ccs3.12016. eCollection 2024 Mar.ABSTRACTLong noncoding RNAs (lncRNAs) are involved in regulatory processes in laryngeal squamous cell carcinoma (LSCC) at posttranscriptional epigenetic modification level. Yet, the function and underlying mechanism behind lncRNA AC004943.2 in LSCC is still obscure. Therefore, the potential role of AC004943.2 in LSCC progression was investigated. The expression of gene or protein was tested by real-time quantitative polymerase chain reaction and western blot. MTT, colony formation, wound healing, and transwell experiments were appl...
Source: Journal of Cell Communication and Signaling - March 28, 2024 Category: Molecular Biology Authors: Xiaowen Zhu Wenming Dong Meijia Zhang Source Type: research
IncRNA AC004943.2 regulates miR-135a-5p and PTK2/P13K axis to promote laryngeal squamous cell carcinoma progression
J Cell Commun Signal. 2024 Feb 9;18(1):e12016. doi: 10.1002/ccs3.12016. eCollection 2024 Mar.ABSTRACTLong noncoding RNAs (lncRNAs) are involved in regulatory processes in laryngeal squamous cell carcinoma (LSCC) at posttranscriptional epigenetic modification level. Yet, the function and underlying mechanism behind lncRNA AC004943.2 in LSCC is still obscure. Therefore, the potential role of AC004943.2 in LSCC progression was investigated. The expression of gene or protein was tested by real-time quantitative polymerase chain reaction and western blot. MTT, colony formation, wound healing, and transwell experiments were appl...
Source: Journal of Cell Communication and Signaling - March 28, 2024 Category: Molecular Biology Authors: Xiaowen Zhu Wenming Dong Meijia Zhang Source Type: research
IncRNA AC004943.2 regulates miR-135a-5p and PTK2/P13K axis to promote laryngeal squamous cell carcinoma progression
J Cell Commun Signal. 2024 Feb 9;18(1):e12016. doi: 10.1002/ccs3.12016. eCollection 2024 Mar.ABSTRACTLong noncoding RNAs (lncRNAs) are involved in regulatory processes in laryngeal squamous cell carcinoma (LSCC) at posttranscriptional epigenetic modification level. Yet, the function and underlying mechanism behind lncRNA AC004943.2 in LSCC is still obscure. Therefore, the potential role of AC004943.2 in LSCC progression was investigated. The expression of gene or protein was tested by real-time quantitative polymerase chain reaction and western blot. MTT, colony formation, wound healing, and transwell experiments were appl...
Source: Journal of Cell Communication and Signaling - March 28, 2024 Category: Molecular Biology Authors: Xiaowen Zhu Wenming Dong Meijia Zhang Source Type: research
IncRNA AC004943.2 regulates miR-135a-5p and PTK2/P13K axis to promote laryngeal squamous cell carcinoma progression
J Cell Commun Signal. 2024 Feb 9;18(1):e12016. doi: 10.1002/ccs3.12016. eCollection 2024 Mar.ABSTRACTLong noncoding RNAs (lncRNAs) are involved in regulatory processes in laryngeal squamous cell carcinoma (LSCC) at posttranscriptional epigenetic modification level. Yet, the function and underlying mechanism behind lncRNA AC004943.2 in LSCC is still obscure. Therefore, the potential role of AC004943.2 in LSCC progression was investigated. The expression of gene or protein was tested by real-time quantitative polymerase chain reaction and western blot. MTT, colony formation, wound healing, and transwell experiments were appl...
Source: Journal of Cell Communication and Signaling - March 28, 2024 Category: Molecular Biology Authors: Xiaowen Zhu Wenming Dong Meijia Zhang Source Type: research
IncRNA AC004943.2 regulates miR-135a-5p and PTK2/P13K axis to promote laryngeal squamous cell carcinoma progression
J Cell Commun Signal. 2024 Feb 9;18(1):e12016. doi: 10.1002/ccs3.12016. eCollection 2024 Mar.ABSTRACTLong noncoding RNAs (lncRNAs) are involved in regulatory processes in laryngeal squamous cell carcinoma (LSCC) at posttranscriptional epigenetic modification level. Yet, the function and underlying mechanism behind lncRNA AC004943.2 in LSCC is still obscure. Therefore, the potential role of AC004943.2 in LSCC progression was investigated. The expression of gene or protein was tested by real-time quantitative polymerase chain reaction and western blot. MTT, colony formation, wound healing, and transwell experiments were appl...
Source: Journal of Cell Communication and Signaling - March 28, 2024 Category: Molecular Biology Authors: Xiaowen Zhu Wenming Dong Meijia Zhang Source Type: research
IncRNA AC004943.2 regulates miR-135a-5p and PTK2/P13K axis to promote laryngeal squamous cell carcinoma progression
J Cell Commun Signal. 2024 Feb 9;18(1):e12016. doi: 10.1002/ccs3.12016. eCollection 2024 Mar.ABSTRACTLong noncoding RNAs (lncRNAs) are involved in regulatory processes in laryngeal squamous cell carcinoma (LSCC) at posttranscriptional epigenetic modification level. Yet, the function and underlying mechanism behind lncRNA AC004943.2 in LSCC is still obscure. Therefore, the potential role of AC004943.2 in LSCC progression was investigated. The expression of gene or protein was tested by real-time quantitative polymerase chain reaction and western blot. MTT, colony formation, wound healing, and transwell experiments were appl...
Source: Journal of Cell Communication and Signaling - March 28, 2024 Category: Molecular Biology Authors: Xiaowen Zhu Wenming Dong Meijia Zhang Source Type: research
IncRNA AC004943.2 regulates miR-135a-5p and PTK2/P13K axis to promote laryngeal squamous cell carcinoma progression
J Cell Commun Signal. 2024 Feb 9;18(1):e12016. doi: 10.1002/ccs3.12016. eCollection 2024 Mar.ABSTRACTLong noncoding RNAs (lncRNAs) are involved in regulatory processes in laryngeal squamous cell carcinoma (LSCC) at posttranscriptional epigenetic modification level. Yet, the function and underlying mechanism behind lncRNA AC004943.2 in LSCC is still obscure. Therefore, the potential role of AC004943.2 in LSCC progression was investigated. The expression of gene or protein was tested by real-time quantitative polymerase chain reaction and western blot. MTT, colony formation, wound healing, and transwell experiments were appl...
Source: Journal of Cell Communication and Signaling - March 28, 2024 Category: Molecular Biology Authors: Xiaowen Zhu Wenming Dong Meijia Zhang Source Type: research
IncRNA AC004943.2 regulates miR-135a-5p and PTK2/P13K axis to promote laryngeal squamous cell carcinoma progression
J Cell Commun Signal. 2024 Feb 9;18(1):e12016. doi: 10.1002/ccs3.12016. eCollection 2024 Mar.ABSTRACTLong noncoding RNAs (lncRNAs) are involved in regulatory processes in laryngeal squamous cell carcinoma (LSCC) at posttranscriptional epigenetic modification level. Yet, the function and underlying mechanism behind lncRNA AC004943.2 in LSCC is still obscure. Therefore, the potential role of AC004943.2 in LSCC progression was investigated. The expression of gene or protein was tested by real-time quantitative polymerase chain reaction and western blot. MTT, colony formation, wound healing, and transwell experiments were appl...
Source: Journal of Cell Communication and Signaling - March 28, 2024 Category: Molecular Biology Authors: Xiaowen Zhu Wenming Dong Meijia Zhang Source Type: research
IncRNA AC004943.2 regulates miR-135a-5p and PTK2/P13K axis to promote laryngeal squamous cell carcinoma progression
J Cell Commun Signal. 2024 Feb 9;18(1):e12016. doi: 10.1002/ccs3.12016. eCollection 2024 Mar.ABSTRACTLong noncoding RNAs (lncRNAs) are involved in regulatory processes in laryngeal squamous cell carcinoma (LSCC) at posttranscriptional epigenetic modification level. Yet, the function and underlying mechanism behind lncRNA AC004943.2 in LSCC is still obscure. Therefore, the potential role of AC004943.2 in LSCC progression was investigated. The expression of gene or protein was tested by real-time quantitative polymerase chain reaction and western blot. MTT, colony formation, wound healing, and transwell experiments were appl...
Source: Journal of Cell Communication and Signaling - March 28, 2024 Category: Molecular Biology Authors: Xiaowen Zhu Wenming Dong Meijia Zhang Source Type: research
IncRNA AC004943.2 regulates miR-135a-5p and PTK2/P13K axis to promote laryngeal squamous cell carcinoma progression
J Cell Commun Signal. 2024 Feb 9;18(1):e12016. doi: 10.1002/ccs3.12016. eCollection 2024 Mar.ABSTRACTLong noncoding RNAs (lncRNAs) are involved in regulatory processes in laryngeal squamous cell carcinoma (LSCC) at posttranscriptional epigenetic modification level. Yet, the function and underlying mechanism behind lncRNA AC004943.2 in LSCC is still obscure. Therefore, the potential role of AC004943.2 in LSCC progression was investigated. The expression of gene or protein was tested by real-time quantitative polymerase chain reaction and western blot. MTT, colony formation, wound healing, and transwell experiments were appl...
Source: Journal of Cell Communication and Signaling - March 28, 2024 Category: Molecular Biology Authors: Xiaowen Zhu Wenming Dong Meijia Zhang Source Type: research
IncRNA AC004943.2 regulates miR-135a-5p and PTK2/P13K axis to promote laryngeal squamous cell carcinoma progression
J Cell Commun Signal. 2024 Feb 9;18(1):e12016. doi: 10.1002/ccs3.12016. eCollection 2024 Mar.ABSTRACTLong noncoding RNAs (lncRNAs) are involved in regulatory processes in laryngeal squamous cell carcinoma (LSCC) at posttranscriptional epigenetic modification level. Yet, the function and underlying mechanism behind lncRNA AC004943.2 in LSCC is still obscure. Therefore, the potential role of AC004943.2 in LSCC progression was investigated. The expression of gene or protein was tested by real-time quantitative polymerase chain reaction and western blot. MTT, colony formation, wound healing, and transwell experiments were appl...
Source: Journal of Cell Communication and Signaling - March 28, 2024 Category: Molecular Biology Authors: Xiaowen Zhu Wenming Dong Meijia Zhang Source Type: research
IncRNA AC004943.2 regulates miR-135a-5p and PTK2/P13K axis to promote laryngeal squamous cell carcinoma progression
J Cell Commun Signal. 2024 Feb 9;18(1):e12016. doi: 10.1002/ccs3.12016. eCollection 2024 Mar.ABSTRACTLong noncoding RNAs (lncRNAs) are involved in regulatory processes in laryngeal squamous cell carcinoma (LSCC) at posttranscriptional epigenetic modification level. Yet, the function and underlying mechanism behind lncRNA AC004943.2 in LSCC is still obscure. Therefore, the potential role of AC004943.2 in LSCC progression was investigated. The expression of gene or protein was tested by real-time quantitative polymerase chain reaction and western blot. MTT, colony formation, wound healing, and transwell experiments were appl...
Source: Journal of Cell Communication and Signaling - March 28, 2024 Category: Molecular Biology Authors: Xiaowen Zhu Wenming Dong Meijia Zhang Source Type: research
