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Laryngectomy plus postoperative radio(system)therapy versus primary radio(system) therapy for the treatment of locally advanced laryngeal and hypopharyngeal cancer - results from the University Clinical Cancer Registry Regensburg
CONCLUSIONS AND SIGNIFICANCE: The results of our study are consistent with the survival data reported in the literature. More detailed systematic data in clinical routine (e.g. relevant comorbidities) are required to ensure guideline-based recommended therapy.PMID:38664954 | DOI:10.1080/00016489.2024.2340086 (Source: Acta Oto-Laryngologica)
Source: Acta Oto-Laryngologica - April 26, 2024 Category: ENT & OMF Authors: Julia Maurer Julian Kuenzel Christopher Bohr Oliver Koelbl Karolina Mueller Michael Koller Oreste-Konrad Concato Veronika Vielsmeier Christoph Suess Source Type: research

Intratumoral therapies in head and neck squamous cell carcinoma: A systematic review and future perspectives
Head and neck squamous cell carcinoma (HNSCC) constitute a diverse category of cancer sites, encompassing oral cavity, pharynx, larynx, nasal cavity, and paranasal sinuses [1].These malignancies represent a significant global health challenge, affecting countries at various levels of development. According to data from The Global Cancer Observatory (GLOBOCAN) in 2020, HNSCC ranked as the seventh most common cancer worldwide [2]. Projections for 2030 predict an alarming global rise, primarily driven by tumors associated with the human papillomavirus (HPV)[1]. (Source: Cancer Treatment Reviews)
Source: Cancer Treatment Reviews - April 26, 2024 Category: Cancer & Oncology Authors: Pablo Jim énez-Labaig, Antonio Rullan, Irene Braña, Alberto Hernando-Calvo, Victor Moreno, Bernard Doger, George Bitar, Derfel Ap Dafydd, Alan Melcher, Kevin J. Harrington Tags: Anti-tumour Treatment Source Type: research

Non-squamous Cancers of the Larynx
AbstractPurpose of ReviewAlthough non-squamous tumors of the larynx are really rare, they may not always be viewed from the same perspective in the multidisciplinary treatment approach once the diagnosis is made. In this review, non-squamous tumors of the larynx and current approaches in treatment will be discussed.Recent FindingsWhen the studies and meta-analyses presented in the last 5 years are evaluated, it is seen that these tumors usually show non-specific symptoms. Due to their submucosal location, the stage of the disease at the time of diagnosis is often advanced. In the literature, treatment may vary in these p...
Source: Current Oncology Reports - April 26, 2024 Category: Cancer & Oncology Source Type: research

A case series of interventions and outcomes in patients with laryngeal squamous cell cancer
J Laryngol Otol. 2024 Apr 25:1-14. doi: 10.1017/S0022215124000707. Online ahead of print.NO ABSTRACTPMID:38659206 | DOI:10.1017/S0022215124000707 (Source: Journal of Laryngology and Otology)
Source: Journal of Laryngology and Otology - April 25, 2024 Category: ENT & OMF Authors: Richard Townsley Jiak Ying Tan Elbert Edy Alison Lim Jeremy McMahon Source Type: research

Cancers, Vol. 16, Pages 1635: Laryngeal Cancer Cells Metabolize 25-Hydroxyvitamin D3 and Respond to 24R,25-dihydroxyvitamin D3 via a Mechanism Dependent on Estrogen Receptor Levels
Zvi Schwartz Studies have evaluated vitamin D3&rsquo;s therapeutic potential in estrogen-responsive cancers, with conflicting findings. We have shown that the proliferation of breast cancer cells is regulated by 24R,25-dihydroxyvitamin D3 (24R,25(OH)2D3) depending on estrogen receptor alpha 66 (ER&alpha;66) expression, suggesting that this could also be the case for estrogen-sensitive laryngeal cancer cells. Accordingly, we examined levels of ER&alpha; isoforms in ER&alpha;66-positive UM-SCC-12 and ER&alpha;66-negative UM-SCC-11A cells and their response to 24R,25(OH)2D3. 24R,...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Cydney D. Dennis Jonathan T. Dillon Prit H. Patel David J. Cohen Matthew S. Halquist Adam C. Pearcy Barbara D. Boyan Zvi Schwartz Tags: Article Source Type: research

Poorly differentiated neuroendocrine carcinoma originating in the subglottic larynx: A case report with imm unohistochemical study
Laryngoscopic images showing a red mass in the sub glottis (black arrow). Key Clinical MessageLaryngeal neuroendocrine carcinomas are the most common non-squamous neoplasm of the larynx. Due to the rarity of the tumor, pathological diagnosis should be confirmed by immunohistochemistry.AbstractLaryngeal neuroendocrine carcinomas (LNECs) are a rare cancer of the head and neck. Few case reports of poorly differentiated neuroendocrine carcinoma originating in the subglottic larynx exist within the literature. In this case, we discuss a 57-year-old patient with a history of four-month hoarseness with a newly diagnosed of poorly...
Source: Clinical Case Reports - April 23, 2024 Category: General Medicine Authors: Mahboobe Asadi, Milad Elyasi, Arvin Shahzamani, Saeedeh Miri Tags: CASE REPORT Source Type: research

Current Status of Partial Laryngeal Surgery for Advanced Laryngeal Cancer: When and Why?
AbstractPurpose of ReviewThis paper aims to evaluate the evolution and current status of partial laryngeal surgery in the treatment of advanced laryngeal cancer (LC). Specifically, recent progress in the selection of both patients and tumors, together with surgical and rehabilitation innovations, have contributed to balancing oncological control with the maintenance of quality of life in na ïve and radiorecurrent patients. The main aspect is represented by the recognized role of open partial horizontal laryngectomies (OPHLs) in this new era of laryngeal cancer treatment.Recent FindingsRecent advancements highlight OPHLs �...
Source: Current Oncology Reports - April 22, 2024 Category: Cancer & Oncology Source Type: research