Identification of novel molecules and pathways associated with fascin actin ‑bundling protein 1 in laryngeal squamous cell carcinoma through comprehensive transcriptome analysis
Int J Mol Med. 2024 Apr;53(4):39. doi: 10.3892/ijmm.2024.5363. Epub 2024 Mar 1.ABSTRACTLaryngeal squamous cell carcinoma (LSCC) is a common malignant tumor with a poor prognosis. Fascin actin‑bundling protein 1 (FSCN1) has been reported to play a crucial role in the development and progression of LSCC; however, the underlying molecular mechanisms remain unknown. Herein, a whole transcriptome microarray analysis was performed to screen for differentially expressed genes (DEGs) in cells in which FSCN1 was knocked down. A total of 462 up and 601 downregulated mRNA transcripts were identified. Functional annotation analysis ...
Source: International Journal of Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Hongliang Liu Wenjing Hao Xinfang Wang Yuliang Zhang Long He Xuting Xue Jiao Yang Chunming Zhang Source Type: research
Identification of novel molecules and pathways associated with fascin actin ‑bundling protein 1 in laryngeal squamous cell carcinoma through comprehensive transcriptome analysis
Int J Mol Med. 2024 Apr;53(4):39. doi: 10.3892/ijmm.2024.5363. Epub 2024 Mar 1.ABSTRACTLaryngeal squamous cell carcinoma (LSCC) is a common malignant tumor with a poor prognosis. Fascin actin‑bundling protein 1 (FSCN1) has been reported to play a crucial role in the development and progression of LSCC; however, the underlying molecular mechanisms remain unknown. Herein, a whole transcriptome microarray analysis was performed to screen for differentially expressed genes (DEGs) in cells in which FSCN1 was knocked down. A total of 462 up and 601 downregulated mRNA transcripts were identified. Functional annotation analysis ...
Source: Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Hongliang Liu Wenjing Hao Xinfang Wang Yuliang Zhang Long He Xuting Xue Jiao Yang Chunming Zhang Source Type: research
Identification of novel molecules and pathways associated with fascin actin ‑bundling protein 1 in laryngeal squamous cell carcinoma through comprehensive transcriptome analysis
Int J Mol Med. 2024 Apr;53(4):39. doi: 10.3892/ijmm.2024.5363. Epub 2024 Mar 1.ABSTRACTLaryngeal squamous cell carcinoma (LSCC) is a common malignant tumor with a poor prognosis. Fascin actin‑bundling protein 1 (FSCN1) has been reported to play a crucial role in the development and progression of LSCC; however, the underlying molecular mechanisms remain unknown. Herein, a whole transcriptome microarray analysis was performed to screen for differentially expressed genes (DEGs) in cells in which FSCN1 was knocked down. A total of 462 up and 601 downregulated mRNA transcripts were identified. Functional annotation analysis ...
Source: International Journal of Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Hongliang Liu Wenjing Hao Xinfang Wang Yuliang Zhang Long He Xuting Xue Jiao Yang Chunming Zhang Source Type: research
Identification of novel molecules and pathways associated with fascin actin ‑bundling protein 1 in laryngeal squamous cell carcinoma through comprehensive transcriptome analysis
Int J Mol Med. 2024 Apr;53(4):39. doi: 10.3892/ijmm.2024.5363. Epub 2024 Mar 1.ABSTRACTLaryngeal squamous cell carcinoma (LSCC) is a common malignant tumor with a poor prognosis. Fascin actin‑bundling protein 1 (FSCN1) has been reported to play a crucial role in the development and progression of LSCC; however, the underlying molecular mechanisms remain unknown. Herein, a whole transcriptome microarray analysis was performed to screen for differentially expressed genes (DEGs) in cells in which FSCN1 was knocked down. A total of 462 up and 601 downregulated mRNA transcripts were identified. Functional annotation analysis ...
Source: Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Hongliang Liu Wenjing Hao Xinfang Wang Yuliang Zhang Long He Xuting Xue Jiao Yang Chunming Zhang Source Type: research
Identification of novel molecules and pathways associated with fascin actin ‑bundling protein 1 in laryngeal squamous cell carcinoma through comprehensive transcriptome analysis
Int J Mol Med. 2024 Apr;53(4):39. doi: 10.3892/ijmm.2024.5363. Epub 2024 Mar 1.ABSTRACTLaryngeal squamous cell carcinoma (LSCC) is a common malignant tumor with a poor prognosis. Fascin actin‑bundling protein 1 (FSCN1) has been reported to play a crucial role in the development and progression of LSCC; however, the underlying molecular mechanisms remain unknown. Herein, a whole transcriptome microarray analysis was performed to screen for differentially expressed genes (DEGs) in cells in which FSCN1 was knocked down. A total of 462 up and 601 downregulated mRNA transcripts were identified. Functional annotation analysis ...
Source: International Journal of Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Hongliang Liu Wenjing Hao Xinfang Wang Yuliang Zhang Long He Xuting Xue Jiao Yang Chunming Zhang Source Type: research
Identification of novel molecules and pathways associated with fascin actin ‑bundling protein 1 in laryngeal squamous cell carcinoma through comprehensive transcriptome analysis
Int J Mol Med. 2024 Apr;53(4):39. doi: 10.3892/ijmm.2024.5363. Epub 2024 Mar 1.ABSTRACTLaryngeal squamous cell carcinoma (LSCC) is a common malignant tumor with a poor prognosis. Fascin actin‑bundling protein 1 (FSCN1) has been reported to play a crucial role in the development and progression of LSCC; however, the underlying molecular mechanisms remain unknown. Herein, a whole transcriptome microarray analysis was performed to screen for differentially expressed genes (DEGs) in cells in which FSCN1 was knocked down. A total of 462 up and 601 downregulated mRNA transcripts were identified. Functional annotation analysis ...
Source: International Journal of Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Hongliang Liu Wenjing Hao Xinfang Wang Yuliang Zhang Long He Xuting Xue Jiao Yang Chunming Zhang Source Type: research
Identification of novel molecules and pathways associated with fascin actin ‑bundling protein 1 in laryngeal squamous cell carcinoma through comprehensive transcriptome analysis
Int J Mol Med. 2024 Apr;53(4):39. doi: 10.3892/ijmm.2024.5363. Epub 2024 Mar 1.ABSTRACTLaryngeal squamous cell carcinoma (LSCC) is a common malignant tumor with a poor prognosis. Fascin actin‑bundling protein 1 (FSCN1) has been reported to play a crucial role in the development and progression of LSCC; however, the underlying molecular mechanisms remain unknown. Herein, a whole transcriptome microarray analysis was performed to screen for differentially expressed genes (DEGs) in cells in which FSCN1 was knocked down. A total of 462 up and 601 downregulated mRNA transcripts were identified. Functional annotation analysis ...
Source: International Journal of Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Hongliang Liu Wenjing Hao Xinfang Wang Yuliang Zhang Long He Xuting Xue Jiao Yang Chunming Zhang Source Type: research
Identification of novel molecules and pathways associated with fascin actin ‑bundling protein 1 in laryngeal squamous cell carcinoma through comprehensive transcriptome analysis
Int J Mol Med. 2024 Apr;53(4):39. doi: 10.3892/ijmm.2024.5363. Epub 2024 Mar 1.ABSTRACTLaryngeal squamous cell carcinoma (LSCC) is a common malignant tumor with a poor prognosis. Fascin actin‑bundling protein 1 (FSCN1) has been reported to play a crucial role in the development and progression of LSCC; however, the underlying molecular mechanisms remain unknown. Herein, a whole transcriptome microarray analysis was performed to screen for differentially expressed genes (DEGs) in cells in which FSCN1 was knocked down. A total of 462 up and 601 downregulated mRNA transcripts were identified. Functional annotation analysis ...
Source: International Journal of Molecular Medicine - March 1, 2024 Category: Molecular Biology Authors: Hongliang Liu Wenjing Hao Xinfang Wang Yuliang Zhang Long He Xuting Xue Jiao Yang Chunming Zhang Source Type: research
Radiotherapy with or without chemotherapy for locally advanced head and neck cancer in elderly patients: analysis of the Head and Neck Cancer Registry of Japan
ConclusionAlthough aggressive CRT is administered to elderly patients in Japan, its effectiveness is uncertain. Further prospective randomized trials are needed to verify whether CRT is superior to RT alone for elderly patients. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research
Incidental Laryngeal Findings in Routine Laryngopharyngeal Reflux Diagnosis
CONCLUSIONS: Evaluation of LPR symptoms may provide otolaryngologists with a tool to identify patients with other findings on fiberoptic laryngoscopy. A laryngoscopic examination should be part of the examination of every patient with LPR to enable diagnosis of incidental findings.PMID:38420641 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - February 29, 2024 Category: General Medicine Authors: Forsan Jahshan Tal Marshak Jamal Qarawany Boaz Markel Amiel Sberro Yonatan Lahav Eli Layous Netanel Eisenbach Isaac Shochat Eyal Sela Ohad Ronen Source Type: research
Transoral laser microsurgery for T1 glottic cancer with anterior commissure: Identifying clinical and radiological variables that predict oncological outcome
CONCLUSION: TLM remains a valuable treatment option for AC involvement. AC3 type involvement and elevated vertical extension ratio were associated with negative prognosis. There have been signs that thyroid cartilage with a narrow angle increases recurrence. Alternative modalities should be kept in mind in the treatment decision of these cases.PMID:38424299 | DOI:10.1007/s00405-024-08513-3 (Source: Cancer Control)
Source: Cancer Control - February 29, 2024 Category: Cancer & Oncology Authors: Caglar Eker Ozgur Surmelioglu Muhammed Dagkiran Omer Kaya Ilda Tanrisever Burak Arpaci Bedir Kaya Sevinc Puren Yucel Karakaya Elvan Onan Source Type: research
Incidental Laryngeal Findings in Routine Laryngopharyngeal Reflux Diagnosis
CONCLUSIONS: Evaluation of LPR symptoms may provide otolaryngologists with a tool to identify patients with other findings on fiberoptic laryngoscopy. A laryngoscopic examination should be part of the examination of every patient with LPR to enable diagnosis of incidental findings.PMID:38420641 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - February 29, 2024 Category: General Medicine Authors: Forsan Jahshan Tal Marshak Jamal Qarawany Boaz Markel Amiel Sberro Yonatan Lahav Eli Layous Netanel Eisenbach Isaac Shochat Eyal Sela Ohad Ronen Source Type: research
