Cancers, Vol. 16, Pages 1635: Laryngeal Cancer Cells Metabolize 25-Hydroxyvitamin D3 and Respond to 24R,25-dihydroxyvitamin D3 via a Mechanism Dependent on Estrogen Receptor Levels
Zvi Schwartz
Studies have evaluated vitamin D3’s therapeutic potential in estrogen-responsive cancers, with conflicting findings. We have shown that the proliferation of breast cancer cells is regulated by 24R,25-dihydroxyvitamin D3 (24R,25(OH)2D3) depending on estrogen receptor alpha 66 (ERα66) expression, suggesting that this could also be the case for estrogen-sensitive laryngeal cancer cells. Accordingly, we examined levels of ERα isoforms in ERα66-positive UM-SCC-12 and ERα66-negative UM-SCC-11A cells and their response to 24R,25(OH)2D3. 24R,...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Cydney D. Dennis Jonathan T. Dillon Prit H. Patel David J. Cohen Matthew S. Halquist Adam C. Pearcy Barbara D. Boyan Zvi Schwartz Tags: Article Source Type: research
Poorly differentiated neuroendocrine carcinoma originating in the subglottic larynx: A case report with imm unohistochemical study
Laryngoscopic images showing a red mass in the sub glottis (black arrow). Key Clinical MessageLaryngeal neuroendocrine carcinomas are the most common non-squamous neoplasm of the larynx. Due to the rarity of the tumor, pathological diagnosis should be confirmed by immunohistochemistry.AbstractLaryngeal neuroendocrine carcinomas (LNECs) are a rare cancer of the head and neck. Few case reports of poorly differentiated neuroendocrine carcinoma originating in the subglottic larynx exist within the literature. In this case, we discuss a 57-year-old patient with a history of four-month hoarseness with a newly diagnosed of poorly...
Source: Clinical Case Reports - April 23, 2024 Category: General Medicine Authors: Mahboobe Asadi,
Milad Elyasi,
Arvin Shahzamani,
Saeedeh Miri Tags: CASE REPORT Source Type: research
Current Status of Partial Laryngeal Surgery for Advanced Laryngeal Cancer: When and Why?
AbstractPurpose of ReviewThis paper aims to evaluate the evolution and current status of partial laryngeal surgery in the treatment of advanced laryngeal cancer (LC). Specifically, recent progress in the selection of both patients and tumors, together with surgical and rehabilitation innovations, have contributed to balancing oncological control with the maintenance of quality of life in na ïve and radiorecurrent patients. The main aspect is represented by the recognized role of open partial horizontal laryngectomies (OPHLs) in this new era of laryngeal cancer treatment.Recent FindingsRecent advancements highlight OPHLs ...
Source: Current Oncology Reports - April 22, 2024 Category: Cancer & Oncology Source Type: research
Inhibitory Effects of Propolis Flavonoids on Migration and Invasion of Laryngeal Cancer Cell and Analysis of Related Signal Pathways
(Source: Journal of Biomedical Nanotechnology)
Source: Journal of Biomedical Nanotechnology - April 20, 2024 Category: Nanotechnology Authors: Yang, Fengbo Li, Fengjiao Chen, Xing Lv, Ping Xiao, Ruhui Ding, Daxiong Li, Qian Tags: research-article Source Type: research
The indirect costs of human papillomavirus-related cancer in Central and Eastern Europe: years of life lost and productivity costs
CONCLUSIONS: There is a high disease burden of HPV-related cancer-related deaths in the CEE region, with a large economic impact to society due to substantial productivity losses. It is critical to implement and reinforce public health measures with the aim to reduce the incidence of HPV-related diseases, and the subsequent premature cancer deaths. Improving HPV screening and increasing vaccination programs, in both male and female populations, could help reduce this burden.PMID:38638098 | DOI:10.1080/13696998.2024.2341572 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - April 19, 2024 Category: Health Management Authors: Ugne Sabale Eugenia Karamousouli Lazar Popovic Zo árd Tibor Krasznai Daniel Harrop Anne Meiwald Robert Hughes Georgie Weston Goran Bencina Source Type: research
Cancers, Vol. 16, Pages 1575: The Role of Estrogen and Estrogen Receptors in Head and Neck Tumors
etić
Head and neck squamous cell carcinoma (HNSCC) is the most common histological form of head and neck tumors (HNTs), which originate from the epithelium of the lips and oral cavity, pharynx, larynx, salivary glands, nasal cavity, and sinuses. The main risk factors include consumption of tobacco in all forms and alcohol, as well as infections with high-risk human papillomaviruses or the Epstein–Barr virus. Regardless of the etiological agent, the risk of developing different types of HNTs is from two to more than six times higher in males than in females. The reason for such disparities probably lies i...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Kranj čević Čonkaš Ozreti ć Tags: Review Source Type: research
Introduction
This edition of Operative Techniques is dedicated to surgical therapy for laryngeal cancer. Surgery for cancer of the larynx enjoys a long and robust evolutionary history, highlighted by milestones involving the development of innovative surgical techniques aimed at partial laryngeal preservation, implementation of advanced technology utilizing laser and robotic instrumentation, and the restoration of voice following laryngectomy. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
Source: Operative Techniques in Otolaryngology - Head and Neck Surgery - April 19, 2024 Category: ENT & OMF Authors: Phillip K Pellitteri Source Type: research
Comparison of 3-year local control using DAHANCA radiotherapy guidelines before and after implementation of five millimetres geometrical GTV to high-dose CTV margin
CONCLUSION: DAHANCA radiotherapy guidelines based on a geometrically generated isotropic CTV1 margin led to less variation in treatment volumes and between centres than previous guidelines. The transition towards consensus GTV-CTV1 margins did not influence local tumour control. The majority of local recurrences were inside CTV1 and covered by the prescription dose.PMID:38636711 | DOI:10.1016/j.radonc.2024.110284 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 18, 2024 Category: Radiology Authors: Ruta Zukauskaite Morten Horsholt Kristensen Jesper Grau Eriksen J ørgen Johansen Eva Sams øe Lars Johnsen Camilla Kj ær Lønkvist Cai Grau Christian R ønn Hansen Source Type: research
Open Organ Preservation for Laryngeal Cancer
As the treatment for laryngeal cancer has evolved over several decades, organ preservation has remained one of the goals of treatment. While chemoradiation therapy is the most widely used treatment modality, open surgical preservation techniques for laryngeal cancer continue to be an option in the surgeon's armamentarium. A summary of the history, anatomic considerations, principles of organ preservation and specific partial laryngectomy techniques are discussed in this review. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
Source: Operative Techniques in Otolaryngology - Head and Neck Surgery - April 17, 2024 Category: ENT & OMF Authors: Thomas L. Kennedy, Priscilla F.A. Pichardo Source Type: research
History and Evolution of the Laryngectomy
This article reviews the history of laryngectomy, progression of surgical techniques, concurrent advancements in vocal rehabilitation, and role of complete and partial laryngectomy procedures in the current era. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
Source: Operative Techniques in Otolaryngology - Head and Neck Surgery - April 17, 2024 Category: ENT & OMF Authors: Ryan N. Hellums, John E. Hanks, Kevin J. Kovatch Source Type: research
Assessing radiation-induced carotid artery injury using ultrasound in patients with head and neck cancer
Head and neck cancers (HNC) are among the most prevalent malignant tumors worldwide. They encompass malignancies of the upper respiratory tract and gastrointestinal system, including nasopharyngeal carcinoma, laryngeal carcinoma, tongue carcinoma, parotid gland carcinoma, and others [1]. The development of HNC is closely related to smoking, excessive drinking, chewing of betel nuts, and viral infection (HBV/HPV). The treatment of HNC includes surgery, radiotherapy (RT), chemotherapy, and immunotherapy. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - April 17, 2024 Category: Radiology Authors: Zhuangzhuang Zheng, Yingying Shen, Jing Su, Xiaorui Ji, Qiang Zhang, Qin Zhao, Xin Jiang Tags: Original Article Source Type: research
Investigating Disparities in Hypopharyngeal/Laryngeal Cancer Survival in Florida With Geospatial Mapping Analysis
CONCLUSION: Our findings suggest that sociodemographic and clinical factors impact OS from hypopharyngeal/laryngeal cancer in Florida and vary geographically within the state. These results will help guide future public health interventions.PMID:38623948 | DOI:10.1177/10732748241246958 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Uche C Ezeh Abdurrahman Al-Awady Isabella Buitron Ming Lee Garrett Forman Sophia Peifer Alana Deo Larissa Sweeny Donald Weed Erin K Kobetz Isildinha M Reis Elizabeth Franzmann Source Type: research
Electrophysiological Changes on Laryngeal Motor Neuropathways Cause Voice Disorders for Postradiotherapy Patients with Nasopharyngeal Carcinoma
This study explored electrophysiological changes in the laryngeal motor neuropathway and determined whether lesions in the laryngeal motor cortex (LMC) and its descending tract contribute to voice deterioration and peripheral nerve palsy in patients with nasopharyngeal carcinoma (NPC) postradiotherapy (RT). (Source: Journal of Voice)
Source: Journal of Voice - April 16, 2024 Category: ENT & OMF Authors: Cui He, Libing Guo, Mingfen Zheng, Hong Peng, Xuhui Zhang, Changhe Fan, Xiangdong Zhao, Pinggui Gong, Zeyi Deng, Guang Xu, Cuijie Chen Source Type: research
Total Laryngectomy
This article will review common indications, basic technique, and complications of the total laryngectomy. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
Source: Operative Techniques in Otolaryngology - Head and Neck Surgery - April 16, 2024 Category: ENT & OMF Authors: Anthony Sanchez, Hector Perez, Max Feng, Shannon Calaguas, Paul Walker, Alfred Simental Source Type: research
Imaging For Larynx Cancer Assessment
Imaging is critical in the evaluation and accurate staging of the patient with laryngeal cancer. Knowledge of relevant anatomy and characteristic patterns of tumor spread guides prognosis and facilitates treatment planning. Furthermore, imaging plays an important role in follow-up of the patient who has undergone successful treatment of their primary laryngeal cancer to detect recurrence and assess treatment-related complications. This review highlights the common imaging modalities used in laryngeal cancer imaging, unique anatomic considerations for each laryngeal subsite, and provides an overview of post-treatment survei...
Source: Operative Techniques in Otolaryngology - Head and Neck Surgery - April 16, 2024 Category: ENT & OMF Authors: Gino J Mongelluzzo, Edward C Fourgas, Gino Mongelluzzo Source Type: research
