High Expression of Sphingosine-1-Phosphate Phosphatase 1 Inversely Correlates with p16 Expression and Is Associated with Poor Prognosis in Laryngeal Cancer Patients

While high protein expression of p16 is associated with better clinical outcomes and a less aggressive phenotype in larynx cancers, the molecular mechanisms underlying the association of p16 over-expression and improved survival in larynx cancer remain to be defined. We hypothesized that p16 protein expression levels are associated with distinct cellular pathways and clinical outcomes in larynx cancer.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: 224 Source Type: research