Lately Diagnosed Acanthamoeba Keratitis Manifesting as an Intrastromal Corneal Abscess: A Case Report
Eye Contact Lens. 2023 Sep 15. doi: 10.1097/ICL.0000000000001034. Online ahead of print.ABSTRACTA 42-year-old female contact lens wearer presented to a local emergency department with a 3-day history of decreased vision and ocular discomfort in her right eye. She was started on topical fluorometholone and oral acyclovir with initial diagnosis of herpes simplex keratitis. After 3 weeks of worsening symptoms, she was diagnosed with bacterial corneal ulcer and treated with levofloxacin eye drops every 2 hr. After 14 days of no improvement, she was referred to our clinic for further workup. Slitlamp examination demonstrated a ...
Source: Herpes - September 15, 2023 Category: Infectious Diseases Authors: Sepehr Feizi Zahra Karjou Hamed Esfandiari Source Type: research
Lately Diagnosed Acanthamoeba Keratitis Manifesting as an Intrastromal Corneal Abscess: A Case Report
Eye Contact Lens. 2023 Sep 15. doi: 10.1097/ICL.0000000000001034. Online ahead of print.ABSTRACTA 42-year-old female contact lens wearer presented to a local emergency department with a 3-day history of decreased vision and ocular discomfort in her right eye. She was started on topical fluorometholone and oral acyclovir with initial diagnosis of herpes simplex keratitis. After 3 weeks of worsening symptoms, she was diagnosed with bacterial corneal ulcer and treated with levofloxacin eye drops every 2 hr. After 14 days of no improvement, she was referred to our clinic for further workup. Slitlamp examination demonstrated a ...
Source: Herpes - September 15, 2023 Category: Infectious Diseases Authors: Sepehr Feizi Zahra Karjou Hamed Esfandiari Source Type: research
Physiologically based pharmacokinetic model to predict drug –drug interactions with the antibody–drug conjugate enfortumab vedotin
AbstractEnfortumab vedotin is an antibody –drug conjugate (ADC) comprised of a Nectin-4–directed antibody and monomethyl auristatin E (MMAE), which is primarily eliminated through P-glycoprotein (P-gp)–mediated excretion and cytochrome P450 3A4 (CYP3A4)–mediated metabolism. A physiologically based pharmacokinetic (PBPK) model was de veloped to predict effects of combined P-gp with CYP3A4 inhibitor/inducer (ketoconazole/rifampin) on MMAE exposure when coadministered with enfortumab vedotin and study enfortumab vedotin with CYP3A4 (midazolam) and P-gp (digoxin) substrate exposure. A PBPK model was built for enfortuma...
Source: Journal of Pharmacokinetics and Pharmacodynamics - August 26, 2023 Category: Drugs & Pharmacology Source Type: research
Clinical poisoning events involving yunaconitine may be highly correlated with metabolism-based interactions: A critical role of CYP3A4
This study aimed to reveal the presumable mechanism by clarifying the metabolic profiles and kinetic-based mechanism of YAC. YAC could be oxidized into 20 metabolites by human liver microsomes, while CYP3A4 have a critical metabolic superiority. Sixteen of the metabolites were primary generated by CYP3A4, and 4 of them were generated only by CYP3A4. The presence of CYP3A inhibitor ketoconazole (KCZ) significantly suppressed the generation of all the 20 metabolites, with 9 of them being suppressed completely (P < 0.05). The plasma exposure (Cmax and AUC0-t values), cardiotoxicity and neurotoxicity of YAC enhanced remarka...
Source: Food and Chemical Toxicology - August 24, 2023 Category: Food Science Authors: Xiaocui Li Yu Fu Huawei Qiu Xueyu Xu Tingting Lin Weiqing Hou Weiying Chen Rong Zhang Zhongqiu Liu Lijun Zhu Source Type: research
Clinical poisoning events involving yunaconitine may be highly correlated with metabolism-based interactions: A critical role of CYP3A4
This study aimed to reveal the presumable mechanism by clarifying the metabolic profiles and kinetic-based mechanism of YAC. YAC could be oxidized into 20 metabolites by human liver microsomes, while CYP3A4 have a critical metabolic superiority. Sixteen of the metabolites were primary generated by CYP3A4, and 4 of them were generated only by CYP3A4. The presence of CYP3A inhibitor ketoconazole (KCZ) significantly suppressed the generation of all the 20 metabolites, with 9 of them being suppressed completely (P < 0.05). The plasma exposure (Cmax and AUC0-t values), cardiotoxicity and neurotoxicity of YAC enhanced remarka...
Source: Food and Chemical Toxicology - August 24, 2023 Category: Food Science Authors: Xiaocui Li Yu Fu Huawei Qiu Xueyu Xu Tingting Lin Weiqing Hou Weiying Chen Rong Zhang Zhongqiu Liu Lijun Zhu Source Type: research
Green synthesis of oncolytic Newcastle disease virus-loaded thiolated chitosan nanoformulation for CD44 targeted delivery and sustained release of virus in cervical cancer xenografts
ConclusionOur findings suggest that encapsulation of the virus in thiolated chitosan and CD44 targeting enhanced retention and sustained release of the virus in tumors as compared to pure NDV, with increased oncolytic effect both in vitro and in vivo. (Source: Cancer Nanotechnology)
Source: Cancer Nanotechnology - August 12, 2023 Category: Cancer & Oncology Source Type: research
Low-Dose Colchicine for Secondary Prevention of Coronary Artery Disease: JACC Review Topic of the Week
J Am Coll Cardiol. 2023 Aug 15;82(7):648-660. doi: 10.1016/j.jacc.2023.05.055.ABSTRACTAmong statin-treated patients, inflammation assessed by means of high-sensitivity C-reactive protein (hsCRP) is a more powerful determinant of cardiovascular death and all-cause mortality than low-density-lipoprotein cholesterol (LDL-C). Several therapies that target residual inflammatory risk significantly reduce vascular event rates. For coronary artery disease patients already taking guideline-directed medical care, including statins, low-dose colchicine (0.5 mg/d orally) has been shown to safely lower major adverse cardiovascular even...
Source: Atherosclerosis - August 9, 2023 Category: Cardiology Authors: Kyle Nelson Valentin Fuster Paul M Ridker Source Type: research
In Silico Screening as a Tool to Prepare Drug-Drug Cocrystals of Ibrutinib-Ketoconazole: a Strategy to Enhance Their Solubility Profiles and Oral Bioavailability
AAPS PharmSciTech. 2023 Aug 8;24(6):164. doi: 10.1208/s12249-023-02621-9.ABSTRACTIbrutinib (IBR) is a biopharmaceutical classification system (BCS) class II drug and an irreversible Bruton's tyrosine kinase (BTK) inhibitor. IBR has an extremely low oral bioavailability due to the activity of the CYP3A4 enzyme. The current intention of the research was to enhance solubility followed by oral bioavailability of IBR using the hot melt extrusion (HME) technique by formulating drug-drug cocrystals (DDCs). Ketoconazole (KET) is an active CYP3A4 inhibitor and was selected based on computational studies and solubility parameter pre...
Source: AAPS PharmSciTech - August 8, 2023 Category: Drugs & Pharmacology Authors: Divya Dhatri Kara Pragathi Devanand Bangera Chetan Hasmukh Mehta Katikala Tanvi Mahalaxmi Rathnanand Source Type: research
In Silico Screening as a Tool to Prepare Drug-Drug Cocrystals of Ibrutinib-Ketoconazole: a Strategy to Enhance Their Solubility Profiles and Oral Bioavailability
AAPS PharmSciTech. 2023 Aug 8;24(6):164. doi: 10.1208/s12249-023-02621-9.ABSTRACTIbrutinib (IBR) is a biopharmaceutical classification system (BCS) class II drug and an irreversible Bruton's tyrosine kinase (BTK) inhibitor. IBR has an extremely low oral bioavailability due to the activity of the CYP3A4 enzyme. The current intention of the research was to enhance solubility followed by oral bioavailability of IBR using the hot melt extrusion (HME) technique by formulating drug-drug cocrystals (DDCs). Ketoconazole (KET) is an active CYP3A4 inhibitor and was selected based on computational studies and solubility parameter pre...
Source: AAPS PharmSciTech - August 8, 2023 Category: Drugs & Pharmacology Authors: Divya Dhatri Kara Pragathi Devanand Bangera Chetan Hasmukh Mehta Katikala Tanvi Mahalaxmi Rathnanand Source Type: research
In Silico Screening as a Tool to Prepare Drug-Drug Cocrystals of Ibrutinib-Ketoconazole: a Strategy to Enhance Their Solubility Profiles and Oral Bioavailability
AAPS PharmSciTech. 2023 Aug 8;24(6):164. doi: 10.1208/s12249-023-02621-9.ABSTRACTIbrutinib (IBR) is a biopharmaceutical classification system (BCS) class II drug and an irreversible Bruton's tyrosine kinase (BTK) inhibitor. IBR has an extremely low oral bioavailability due to the activity of the CYP3A4 enzyme. The current intention of the research was to enhance solubility followed by oral bioavailability of IBR using the hot melt extrusion (HME) technique by formulating drug-drug cocrystals (DDCs). Ketoconazole (KET) is an active CYP3A4 inhibitor and was selected based on computational studies and solubility parameter pre...
Source: AAPS PharmSciTech - August 8, 2023 Category: Drugs & Pharmacology Authors: Divya Dhatri Kara Pragathi Devanand Bangera Chetan Hasmukh Mehta Katikala Tanvi Mahalaxmi Rathnanand Source Type: research
Drug-Polymer Miscibility and the Overlap Concentration (C*) as Measured by Rheology: Variation of Polymer Structure
ConclusionsOur findings will aid researchers in designing or selecting appropriate polymers to inhibit crystallization of poorly soluble drugs. This research also suggests thatC* as determined by rheology can be used to compare drug-polymer interactions for similar molecular weight polymers.Graphical abstract (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - August 8, 2023 Category: Drugs & Pharmacology Source Type: research
Antifungal Resistance, Susceptibility Testing and Treatment of Recalcitrant Dermatophytosis Caused by Trichophyton indotineae: A North American Perspective on Management
AbstractThere is an ongoing epidemic of chronic, relapsing dermatophytoses caused byTrichophyton indotineae that are unresponsive to one or multiple antifungal agents. Although this new species may have originated from the Indian subcontinent, there has been a notable increase of its reporting in other countries. Based on current literature, antifungal susceptibility testing (AFST) showed a large variat ion of terbinafine minimum inhibitory concentrations (MICs) (0.04 to ≥ 32 µg/ml). Elevated terbinafine MICs can be attributed to mutations in the squalene epoxidase gene (single mutations: Leu393Phe, Leu393Ser, Phe397Le...
Source: American Journal of Clinical Dermatology - August 8, 2023 Category: Dermatology Source Type: research
