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Global Consumption Trend of Antifungal Agents in Humans From 2008 to 2018: Data From 65 Middle- and High-Income Countries
ConclusionGlobal consumption of triazoles and terbinafine has gradually increased in middle- and high-income countries. Life-saving antifungal agents, including echinocandins and polyenes, are available only parenterally and may be underutilized, mainly in middle-income countries. Future research on country-specific epidemiology is warranted to guide health policy coordination to ensure equitable access to appropriate use of antifungal agents. (Source: Drugs)
Source: Drugs - August 12, 2022 Category: Drugs & Pharmacology Source Type: research

Prediction of Food Effect On In Vitro Drug Dissolution into Biorelevant Media: Contributions of Solubility Enhancement and Relatively Low Colloid Diffusivity
Eur J Pharm Sci. 2022 Aug 6:106274. doi: 10.1016/j.ejps.2022.106274. Online ahead of print.ABSTRACTA prior model that showed good predictability for fed-state and fasted-state biorelevant media was extended to predict the degree to which fed-state biorelevant media (i.e. FeSSGF and FeSSIF-V2) enhanced drug dissolution over fasted-state biorelevant media (i.e. FaSSGF and FaSSIF-V2): ϕfood=vfast1/6vfed1/6·(ff,fedDD2/3+fm,fedDD-M,fed2/3)[Dt,fed](ff,fastDD2/3+fm,fastDD-M,fast2/3)[Dt,fast] where ϕfood is the degree by which fed-state biorelevant media enhanced in vitro drug dissolution over fasted state biorelevant media, ff...
Source: European Journal of Pharmaceutical Sciences - August 9, 2022 Category: Drugs & Pharmacology Authors: Raqeeb Jamil James E Polli Source Type: research

Paraneoplastic syndromes: A focus on pathophysiology and supportive care
CONCLUSION: Supportive care for PNSs lends opportunities to pharmacists to add quality, value, and safety.PMID:35916756 | DOI:10.1093/ajhp/zxac211 (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - August 2, 2022 Category: Drugs & Pharmacology Authors: Clement Chung Emily Allen Godsfavour Umoru Source Type: research

Role of nuclear pregnane X receptor in Cu-induced lipid metabolism and xenobiotic responses in largemouth bass (Micropterus salmoides)
The pregnane X receptor (PXR) is a master xenobiotic-sensing receptor in response to toxic byproducts, as well as a key regulator in intermediary lipid metabolism. Therefore, the present study was conducted to investigate the potential role of PXR in mediating the lipid dysregulation and xenobiotic responses under Cu-induced stress in largemouth bass (Micropterus salmoides). Four groups of largemouth bass (52.66 ± 0.03 g) were treated with control, Cu waterborne (9.44 μmol/L), Cu+RIF (Rifampicin, 100 mg/kg, PXR activator), and Cu+KET (Ketoconazole, 20 mg/kg, PXR inhibitor) for 48 h. Results showed that Cu exposure sign...
Source: Frontiers in Endocrinology - July 28, 2022 Category: Endocrinology Source Type: research

Case Report: Progression of a Silent Corticotroph Tumor to an Aggressive Secreting Corticotroph Tumor, Treated by Temozolomide. Changes in the Clinic, the Pathology, and the β-Catenin and α-SMA Expression
Clinically silent corticotroph tumors are usually macroadenomas that comprise 20% of ACTH tumors. They frequently progress to aggressive tumors with high recurrence, invasiveness, and on rare occasions, they may become hormonally active causing Cushing’s disease. Trustable biomarkers that can predict their aggressive course, as well as their response to traditional or new therapies, are paramount. Aberrant β-Catenin expression and localization have been proposed as responsible for several malignancies including pituitary tumors. Nevertheless, the role of β-Catenin in the aggressive transformation of silent corticotropi...
Source: Frontiers in Endocrinology - July 19, 2022 Category: Endocrinology Source Type: research

Molecules, Vol. 27, Pages 4574: Qualitative, Quantitative, Cytotoxic, Free Radical Scavenging, and Antimicrobial Characteristics of Hypericum lanuginosum from Palestine
t Hypericum lanuginosum is one of the traditional medicinal plants that grows in the arid area of the Al-Naqab desert in Palestine and is used by Bedouins to heal various communicable and non-communicable illnesses. The purpose of this investigation was to estimate the total phenolic, flavonoid, and tannin contents of aqueous, methanol, acetone, and hexane H. lanuginosum extracts and evaluate their cytotoxic, anti-oxidative, and antimicrobial properties. Qualitative phytochemical tests were used to identify the major phytochemical classes in H. lanuginosum extracts, while total phenol, flavonoid, and tannin contents we...
Source: Molecules - July 18, 2022 Category: Chemistry Authors: Nidal Jaradat Tags: Article Source Type: research

Molecules, Vol. 27, Pages 4583: Synthesis of a Novel Unexpected Cu(II) & ndash;Thiazolidine Complex & mdash;X-ray Structure, Hirshfeld Surface Analysis, and Biological Studies
Molecules, Vol. 27, Pages 4583: Synthesis of a Novel Unexpected Cu(II)–Thiazolidine Complex—X-ray Structure, Hirshfeld Surface Analysis, and Biological Studies Molecules doi: 10.3390/molecules27144583 Authors: Mezna Saleh Altowyan Samar M. S. M. Khalil Dhuha Al-Wahaib Assem Barakat Saied M. Soliman Ali Eldissouky Ali Hemmat A. Elbadawy An unexpected trinuclear Cu(II)&ndash;thiazolidine complex has been synthesized by mixing CuCl2&middot;2H2O with the Schiff base ligand, 1-(((4,5-dihydrothiazol-2-yl)ethylidene)hydrazono)methyl)phenol L, in ethanol. Unexpectedly, the re...
Source: Molecules - July 18, 2022 Category: Chemistry Authors: Mezna Saleh Altowyan Samar M. S. M. Khalil Dhuha Al-Wahaib Assem Barakat Saied M. Soliman Ali Eldissouky Ali Hemmat A. Elbadawy Tags: Article Source Type: research

Central nervous system infections caused by pathogenic free-living amoebae: An Indian perspective
Trop Biomed. 2022 Jun 1;39(2):265-280. doi: 10.47665/tb.39.2.017.ABSTRACTPathogenic free-living amoebae (FLA), namely Acanthamoeba sp., Naegleria fowleri and Balamuthia mandrillaris are distributed worldwide. These neurotropic amoebae can cause fatal central nervous system (CNS) infections in humans. This review deals with the demographic characteristics, symptoms, diagnosis, and treatment outcomes of patients with CNS infections caused by FLA documented in India. There have been 42, 25, and 4 case reports of Acanthamoeba granulomatous amoebic encephalitis (GAE), N. fowleri primary amoebic meningoencephalitis (PAM), and B....
Source: Tropical Biomedicine - July 15, 2022 Category: Tropical Medicine Authors: R Raju S Khurana A Mahadevan D V John Source Type: research