Distinct effects of form selective cytochrome P450 inhibitors on cytochrome P450-mediated monooxygenase and hydrogen peroxide generating NADPH oxidase
Toxicol Appl Pharmacol. 2022 Sep 26:116258. doi: 10.1016/j.taap.2022.116258. Online ahead of print.ABSTRACTA characteristic of cytochrome P450 (CYP) enzymes is their ability to generate H2O2, either directly or indirectly via superoxide anion, a reaction referred to as "NADPH oxidase" activity. H2O2 production by CYPs can lead to the accumulation of cytotoxic reactive oxygen species which can compromise cellular functioning and contribute to tissue injury. Herein we determined if form selective CYP inhibitors could distinguish between the activities of the monooxygenase and NADPH oxidase activities of rat recombinant CYP1A...
Source: Toxicology and Applied Pharmacology - September 29, 2022 Category: Toxicology Authors: Vladimir Mishin Diane E Heck Yi-Hua Jan Jason R Richardson Jeffrey D Laskin Source Type: research
Distinct effects of form selective cytochrome P450 inhibitors on cytochrome P450-mediated monooxygenase and hydrogen peroxide generating NADPH oxidase
Toxicol Appl Pharmacol. 2022 Sep 26:116258. doi: 10.1016/j.taap.2022.116258. Online ahead of print.ABSTRACTA characteristic of cytochrome P450 (CYP) enzymes is their ability to generate H2O2, either directly or indirectly via superoxide anion, a reaction referred to as "NADPH oxidase" activity. H2O2 production by CYPs can lead to the accumulation of cytotoxic reactive oxygen species which can compromise cellular functioning and contribute to tissue injury. Herein we determined if form selective CYP inhibitors could distinguish between the activities of the monooxygenase and NADPH oxidase activities of rat recombinant CYP1A...
Source: Toxicology and Applied Pharmacology - September 29, 2022 Category: Toxicology Authors: Vladimir Mishin Diane E Heck Yi-Hua Jan Jason R Richardson Jeffrey D Laskin Source Type: research
Expression pattern of drug-resistance genes ERG11 and TAC1 in Candida albicans Clinical isolates
CONCLUSION: Our finding revealed that incidence of drug resistance in C. albicans is not simply controlled by genes but is a multi-factorial phenomenon, where several factors and mechanisms are involved in the process of drug resistance.PMID:36169896 | DOI:10.1007/s11033-022-07878-0 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - September 28, 2022 Category: Molecular Biology Authors: Majid Zare-Bidaki Anis Maleki Nahid Ghanbarzadeh Fatemeh Nikoomanesh Source Type: research
Expression pattern of drug-resistance genes ERG11 and TAC1 in Candida albicans Clinical isolates
CONCLUSION: Our finding revealed that incidence of drug resistance in C. albicans is not simply controlled by genes but is a multi-factorial phenomenon, where several factors and mechanisms are involved in the process of drug resistance.PMID:36169896 | DOI:10.1007/s11033-022-07878-0 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - September 28, 2022 Category: Molecular Biology Authors: Majid Zare-Bidaki Anis Maleki Nahid Ghanbarzadeh Fatemeh Nikoomanesh Source Type: research
The function of adrenal glands in children and adolescents during and after oncological treatment
Pediatr Endocrinol Diabetes Metab. 2022 Sep 22:47553. doi: 10.5114/pedm.2022.118319. Online ahead of print.ABSTRACTThe purpose of this work was to present the current state of knowledge on the effects of frequently used therapeutic forms, selected pharmacotherapy (including glucocorticosteroids, immune checkpoint inhibitors, mitotane, metyrapone, aminoglutetimide, etomidate, ketoconazole, fluconazole), but also radiation therapy on the functioning of the hypothalamic-pituitary-adrenal axis in children and adolescent during and after oncological treatment. The most common pediatric cancers, where complications of adrenal in...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 22, 2022 Category: Endocrinology Authors: Barbara Hull Anna Wedrychowicz Source Type: research
The function of adrenal glands in children and adolescents during and after oncological treatment
Pediatr Endocrinol Diabetes Metab. 2022 Sep 22:47553. doi: 10.5114/pedm.2022.118319. Online ahead of print.ABSTRACTThe purpose of this work was to present the current state of knowledge on the effects of frequently used therapeutic forms, selected pharmacotherapy (including glucocorticosteroids, immune checkpoint inhibitors, mitotane, metyrapone, aminoglutetimide, etomidate, ketoconazole, fluconazole), but also radiation therapy on the functioning of the hypothalamic-pituitary-adrenal axis in children and adolescent during and after oncological treatment. The most common pediatric cancers, where complications of adrenal in...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 22, 2022 Category: Endocrinology Authors: Barbara Hull Anna Wedrychowicz Source Type: research
The function of adrenal glands in children and adolescents during and after oncological treatment
Pediatr Endocrinol Diabetes Metab. 2022 Sep 22:47553. doi: 10.5114/pedm.2022.118319. Online ahead of print.ABSTRACTThe purpose of this work was to present the current state of knowledge on the effects of frequently used therapeutic forms, selected pharmacotherapy (including glucocorticosteroids, immune checkpoint inhibitors, mitotane, metyrapone, aminoglutetimide, etomidate, ketoconazole, fluconazole), but also radiation therapy on the functioning of the hypothalamic-pituitary-adrenal axis in children and adolescent during and after oncological treatment. The most common pediatric cancers, where complications of adrenal in...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 22, 2022 Category: Endocrinology Authors: Barbara Hull Anna Wedrychowicz Source Type: research
The function of adrenal glands in children and adolescents during and after oncological treatment
Pediatr Endocrinol Diabetes Metab. 2022 Sep 22:47553. doi: 10.5114/pedm.2022.118319. Online ahead of print.ABSTRACTThe purpose of this work was to present the current state of knowledge on the effects of frequently used therapeutic forms, selected pharmacotherapy (including glucocorticosteroids, immune checkpoint inhibitors, mitotane, metyrapone, aminoglutetimide, etomidate, ketoconazole, fluconazole), but also radiation therapy on the functioning of the hypothalamic-pituitary-adrenal axis in children and adolescent during and after oncological treatment. The most common pediatric cancers, where complications of adrenal in...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 22, 2022 Category: Endocrinology Authors: Barbara Hull Anna Wedrychowicz Source Type: research
The function of adrenal glands in children and adolescents during and after oncological treatment
Pediatr Endocrinol Diabetes Metab. 2022 Sep 22:47553. doi: 10.5114/pedm.2022.118319. Online ahead of print.ABSTRACTThe purpose of this work was to present the current state of knowledge on the effects of frequently used therapeutic forms, selected pharmacotherapy (including glucocorticosteroids, immune checkpoint inhibitors, mitotane, metyrapone, aminoglutetimide, etomidate, ketoconazole, fluconazole), but also radiation therapy on the functioning of the hypothalamic-pituitary-adrenal axis in children and adolescent during and after oncological treatment. The most common pediatric cancers, where complications of adrenal in...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 22, 2022 Category: Endocrinology Authors: Barbara Hull Anna Wedrychowicz Source Type: research
The function of adrenal glands in children and adolescents during and after oncological treatment
Pediatr Endocrinol Diabetes Metab. 2022 Sep 22:47553. doi: 10.5114/pedm.2022.118319. Online ahead of print.ABSTRACTThe purpose of this work was to present the current state of knowledge on the effects of frequently used therapeutic forms, selected pharmacotherapy (including glucocorticosteroids, immune checkpoint inhibitors, mitotane, metyrapone, aminoglutetimide, etomidate, ketoconazole, fluconazole), but also radiation therapy on the functioning of the hypothalamic-pituitary-adrenal axis in children and adolescent during and after oncological treatment. The most common pediatric cancers, where complications of adrenal in...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 22, 2022 Category: Endocrinology Authors: Barbara Hull Anna Wedrychowicz Source Type: research
The function of adrenal glands in children and adolescents during and after oncological treatment
Pediatr Endocrinol Diabetes Metab. 2022 Sep 22:47553. doi: 10.5114/pedm.2022.118319. Online ahead of print.ABSTRACTThe purpose of this work was to present the current state of knowledge on the effects of frequently used therapeutic forms, selected pharmacotherapy (including glucocorticosteroids, immune checkpoint inhibitors, mitotane, metyrapone, aminoglutetimide, etomidate, ketoconazole, fluconazole), but also radiation therapy on the functioning of the hypothalamic-pituitary-adrenal axis in children and adolescent during and after oncological treatment. The most common pediatric cancers, where complications of adrenal in...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 22, 2022 Category: Endocrinology Authors: Barbara Hull Anna Wedrychowicz Source Type: research
The function of adrenal glands in children and adolescents during and after oncological treatment
Pediatr Endocrinol Diabetes Metab. 2022 Sep 22:47553. doi: 10.5114/pedm.2022.118319. Online ahead of print.ABSTRACTThe purpose of this work was to present the current state of knowledge on the effects of frequently used therapeutic forms, selected pharmacotherapy (including glucocorticosteroids, immune checkpoint inhibitors, mitotane, metyrapone, aminoglutetimide, etomidate, ketoconazole, fluconazole), but also radiation therapy on the functioning of the hypothalamic-pituitary-adrenal axis in children and adolescent during and after oncological treatment. The most common pediatric cancers, where complications of adrenal in...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 22, 2022 Category: Endocrinology Authors: Barbara Hull Anna Wedrychowicz Source Type: research
The function of adrenal glands in children and adolescents during and after oncological treatment
Pediatr Endocrinol Diabetes Metab. 2022 Sep 22:47553. doi: 10.5114/pedm.2022.118319. Online ahead of print.ABSTRACTThe purpose of this work was to present the current state of knowledge on the effects of frequently used therapeutic forms, selected pharmacotherapy (including glucocorticosteroids, immune checkpoint inhibitors, mitotane, metyrapone, aminoglutetimide, etomidate, ketoconazole, fluconazole), but also radiation therapy on the functioning of the hypothalamic-pituitary-adrenal axis in children and adolescent during and after oncological treatment. The most common pediatric cancers, where complications of adrenal in...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 22, 2022 Category: Endocrinology Authors: Barbara Hull Anna Wedrychowicz Source Type: research
The function of adrenal glands in children and adolescents during and after oncological treatment
Pediatr Endocrinol Diabetes Metab. 2022 Sep 22:47553. doi: 10.5114/pedm.2022.118319. Online ahead of print.ABSTRACTThe purpose of this work was to present the current state of knowledge on the effects of frequently used therapeutic forms, selected pharmacotherapy (including glucocorticosteroids, immune checkpoint inhibitors, mitotane, metyrapone, aminoglutetimide, etomidate, ketoconazole, fluconazole), but also radiation therapy on the functioning of the hypothalamic-pituitary-adrenal axis in children and adolescent during and after oncological treatment. The most common pediatric cancers, where complications of adrenal in...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 22, 2022 Category: Endocrinology Authors: Barbara Hull Anna Wedrychowicz Source Type: research
The function of adrenal glands in children and adolescents during and after oncological treatment
Pediatr Endocrinol Diabetes Metab. 2022 Sep 22:47553. doi: 10.5114/pedm.2022.118319. Online ahead of print.ABSTRACTThe purpose of this work was to present the current state of knowledge on the effects of frequently used therapeutic forms, selected pharmacotherapy (including glucocorticosteroids, immune checkpoint inhibitors, mitotane, metyrapone, aminoglutetimide, etomidate, ketoconazole, fluconazole), but also radiation therapy on the functioning of the hypothalamic-pituitary-adrenal axis in children and adolescent during and after oncological treatment. The most common pediatric cancers, where complications of adrenal in...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 22, 2022 Category: Endocrinology Authors: Barbara Hull Anna Wedrychowicz Source Type: research
