Cabergoline/Ketoconazole/Octreotide
(Source: Reactions Weekly)
Source: Reactions Weekly - April 1, 2024 Category: Drugs & Pharmacology Source Type: research

Effects of Clarithromycin and Ketoconazole on FK506 Metabolism in Different CYP3A4 Genotype Recombinant Metabolic Enzyme Systems
CONCLUSION: Compared with CYP3A4*1, CYP3A4*18 has a greater metabolism of FK506, clarithromycin and ketoconazole can inhibit both the enzymatic activities of CYP3A4*1 and CYP3A4*18, consequently affecting the metabolism of FK506 and the inhibitory on CYP3A4*1 is stronger.PMID:38523538 | DOI:10.2174/0113892002286019240315052145 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 25, 2024 Category: Drugs & Pharmacology Authors: Jinhua Wen Yuwei Xiao Menghua Zhao Chen Yang Weiqiang Hu Source Type: research

Effects of Clarithromycin and Ketoconazole on FK506 Metabolism in Different CYP3A4 Genotype Recombinant Metabolic Enzyme Systems
CONCLUSION: Compared with CYP3A4*1, CYP3A4*18 has a greater metabolism of FK506, clarithromycin and ketoconazole can inhibit both the enzymatic activities of CYP3A4*1 and CYP3A4*18, consequently affecting the metabolism of FK506 and the inhibitory on CYP3A4*1 is stronger.PMID:38523538 | DOI:10.2174/0113892002286019240315052145 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 25, 2024 Category: Drugs & Pharmacology Authors: Jinhua Wen Yuwei Xiao Menghua Zhao Chen Yang Weiqiang Hu Source Type: research

Effects of Clarithromycin and Ketoconazole on FK506 Metabolism in Different CYP3A4 Genotype Recombinant Metabolic Enzyme Systems
CONCLUSION: Compared with CYP3A4*1, CYP3A4*18 has a greater metabolism of FK506, clarithromycin and ketoconazole can inhibit both the enzymatic activities of CYP3A4*1 and CYP3A4*18, consequently affecting the metabolism of FK506 and the inhibitory on CYP3A4*1 is stronger.PMID:38523538 | DOI:10.2174/0113892002286019240315052145 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 25, 2024 Category: Drugs & Pharmacology Authors: Jinhua Wen Yuwei Xiao Menghua Zhao Chen Yang Weiqiang Hu Source Type: research

Effects of Clarithromycin and Ketoconazole on FK506 Metabolism in Different CYP3A4 Genotype Recombinant Metabolic Enzyme Systems
CONCLUSION: Compared with CYP3A4*1, CYP3A4*18 has a greater metabolism of FK506, clarithromycin and ketoconazole can inhibit both the enzymatic activities of CYP3A4*1 and CYP3A4*18, consequently affecting the metabolism of FK506 and the inhibitory on CYP3A4*1 is stronger.PMID:38523538 | DOI:10.2174/0113892002286019240315052145 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 25, 2024 Category: Drugs & Pharmacology Authors: Jinhua Wen Yuwei Xiao Menghua Zhao Chen Yang Weiqiang Hu Source Type: research

Effects of Clarithromycin and Ketoconazole on FK506 Metabolism in Different CYP3A4 Genotype Recombinant Metabolic Enzyme Systems
CONCLUSION: Compared with CYP3A4*1, CYP3A4*18 has a greater metabolism of FK506, clarithromycin and ketoconazole can inhibit both the enzymatic activities of CYP3A4*1 and CYP3A4*18, consequently affecting the metabolism of FK506 and the inhibitory on CYP3A4*1 is stronger.PMID:38523538 | DOI:10.2174/0113892002286019240315052145 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 25, 2024 Category: Drugs & Pharmacology Authors: Jinhua Wen Yuwei Xiao Menghua Zhao Chen Yang Weiqiang Hu Source Type: research

Effects of Clarithromycin and Ketoconazole on FK506 Metabolism in Different CYP3A4 Genotype Recombinant Metabolic Enzyme Systems
CONCLUSION: Compared with CYP3A4*1, CYP3A4*18 has a greater metabolism of FK506, clarithromycin and ketoconazole can inhibit both the enzymatic activities of CYP3A4*1 and CYP3A4*18, consequently affecting the metabolism of FK506 and the inhibitory on CYP3A4*1 is stronger.PMID:38523538 | DOI:10.2174/0113892002286019240315052145 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 25, 2024 Category: Drugs & Pharmacology Authors: Jinhua Wen Yuwei Xiao Menghua Zhao Chen Yang Weiqiang Hu Source Type: research

Effects of Clarithromycin and Ketoconazole on FK506 Metabolism in Different CYP3A4 Genotype Recombinant Metabolic Enzyme Systems
CONCLUSION: Compared with CYP3A4*1, CYP3A4*18 has a greater metabolism of FK506, clarithromycin and ketoconazole can inhibit both the enzymatic activities of CYP3A4*1 and CYP3A4*18, consequently affecting the metabolism of FK506 and the inhibitory on CYP3A4*1 is stronger.PMID:38523538 | DOI:10.2174/0113892002286019240315052145 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 25, 2024 Category: Drugs & Pharmacology Authors: Jinhua Wen Yuwei Xiao Menghua Zhao Chen Yang Weiqiang Hu Source Type: research

Effects of Clarithromycin and Ketoconazole on FK506 Metabolism in Different CYP3A4 Genotype Recombinant Metabolic Enzyme Systems
CONCLUSION: Compared with CYP3A4*1, CYP3A4*18 has a greater metabolism of FK506, clarithromycin and ketoconazole can inhibit both the enzymatic activities of CYP3A4*1 and CYP3A4*18, consequently affecting the metabolism of FK506 and the inhibitory on CYP3A4*1 is stronger.PMID:38523538 | DOI:10.2174/0113892002286019240315052145 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 25, 2024 Category: Drugs & Pharmacology Authors: Jinhua Wen Yuwei Xiao Menghua Zhao Chen Yang Weiqiang Hu Source Type: research

Anti-fungal effects of novel N-(tert-butyl)-2-(pyridin-2-yl)imidazo[1,2-a]pyridin-3-amine derivative and it's in-vitro, in-silico, and mode of action against Candida spp
In this study, two newly synthesized imidazo[1,2-a]pyridine derivative (Probe I and Probe II) molecules were investigated for its antimicrobial potency against of a panel of bacterial (Gram-positive and Gram-negative bacteria) and fungal pathogens. Among the different types of pathogens, we found that Probe II showed excellent antifungal activity against fungal pathogens, based on the preliminary screening the potent molecule further investigated against multidrug-resistance Candida sp. (n = 10) and compared with commercial molecules. In addition, in-silico molecular docking, its dynamics, absorption, distribution, metabol...
Source: Archives of Microbiology - March 21, 2024 Category: Microbiology Authors: Manivannan Nandhagopal Ramanjaneyulu Mala Kanagasabai Somarathinam Divya Dhakshinamurthy Mathivanan Narayanasamy Priyadharshni Vijayan Manimuthu Mani Shankar Source Type: research

Anti-fungal effects of novel N-(tert-butyl)-2-(pyridin-2-yl)imidazo[1,2-a]pyridin-3-amine derivative and it's in-vitro, in-silico, and mode of action against Candida spp
In this study, two newly synthesized imidazo[1,2-a]pyridine derivative (Probe I and Probe II) molecules were investigated for its antimicrobial potency against of a panel of bacterial (Gram-positive and Gram-negative bacteria) and fungal pathogens. Among the different types of pathogens, we found that Probe II showed excellent antifungal activity against fungal pathogens, based on the preliminary screening the potent molecule further investigated against multidrug-resistance Candida sp. (n = 10) and compared with commercial molecules. In addition, in-silico molecular docking, its dynamics, absorption, distribution, metabol...
Source: Archives of Microbiology - March 21, 2024 Category: Microbiology Authors: Manivannan Nandhagopal Ramanjaneyulu Mala Kanagasabai Somarathinam Divya Dhakshinamurthy Mathivanan Narayanasamy Priyadharshni Vijayan Manimuthu Mani Shankar Source Type: research

Zoonotic Majocchi's Granuloma of the Vulva
Skinmed. 2024 Mar 18;22(1):67-68. eCollection 2024.ABSTRACTA healthy 32-year-old woman presented to clinic with tender pruritic lesions of 2-month duration at the vulva and lesions for weeks on the shins. She was treated with topical corticosteroids and intravenous vancomycin without significant improvement. On examination, dozens of follicular hemorrhagic papulopustules were detected at the suprapubic area and vulva (Figure 1). Similar but less prominent lesions were observed on the shins as well. Biopsies of the vulva and shin revealed a follicular inflammatory infiltrate of neutrophils, histiocytes, and lymphocytes as w...
Source: Skinmed - March 18, 2024 Category: Dermatology Authors: Larissa M Pastore Camille E Introcaso Source Type: research

Zoonotic Majocchi's Granuloma of the Vulva
Skinmed. 2024 Mar 18;22(1):67-68. eCollection 2024.ABSTRACTA healthy 32-year-old woman presented to clinic with tender pruritic lesions of 2-month duration at the vulva and lesions for weeks on the shins. She was treated with topical corticosteroids and intravenous vancomycin without significant improvement. On examination, dozens of follicular hemorrhagic papulopustules were detected at the suprapubic area and vulva (Figure 1). Similar but less prominent lesions were observed on the shins as well. Biopsies of the vulva and shin revealed a follicular inflammatory infiltrate of neutrophils, histiocytes, and lymphocytes as w...
Source: Skinmed - March 18, 2024 Category: Dermatology Authors: Larissa M Pastore Camille E Introcaso Source Type: research

Zoonotic Majocchi's Granuloma of the Vulva
Skinmed. 2024 Mar 18;22(1):67-68. eCollection 2024.ABSTRACTA healthy 32-year-old woman presented to clinic with tender pruritic lesions of 2-month duration at the vulva and lesions for weeks on the shins. She was treated with topical corticosteroids and intravenous vancomycin without significant improvement. On examination, dozens of follicular hemorrhagic papulopustules were detected at the suprapubic area and vulva (Figure 1). Similar but less prominent lesions were observed on the shins as well. Biopsies of the vulva and shin revealed a follicular inflammatory infiltrate of neutrophils, histiocytes, and lymphocytes as w...
Source: Skinmed - March 18, 2024 Category: Dermatology Authors: Larissa M Pastore Camille E Introcaso Source Type: research

Zoonotic Majocchi's Granuloma of the Vulva
Skinmed. 2024 Mar 18;22(1):67-68. eCollection 2024.ABSTRACTA healthy 32-year-old woman presented to clinic with tender pruritic lesions of 2-month duration at the vulva and lesions for weeks on the shins. She was treated with topical corticosteroids and intravenous vancomycin without significant improvement. On examination, dozens of follicular hemorrhagic papulopustules were detected at the suprapubic area and vulva (Figure 1). Similar but less prominent lesions were observed on the shins as well. Biopsies of the vulva and shin revealed a follicular inflammatory infiltrate of neutrophils, histiocytes, and lymphocytes as w...
Source: Skinmed - March 18, 2024 Category: Dermatology Authors: Larissa M Pastore Camille E Introcaso Source Type: research