Hexokinase 2 confers radio-resistance in hepatocellular carcinoma by promoting autophagy-dependent degradation of AIMP2
Cell Death Dis. 2023 Aug 1;14(8):488. doi: 10.1038/s41419-023-06009-2.ABSTRACTWith technological advancements, radiotherapy (RT) has become an effective non-surgical treatment for hepatocellular carcinoma (HCC), comprehensively improving the local control rate of patients with HCC. However, some patients with HCC still experience radio-resistance, cancer recurrence, and distant metastasis following RT. Our previous study has revealed that hexokinase 2 (HK2), a potent oncogene, was overexpressed in radio-resistant HCC cell lines; however, its role in HCC radio-resistance remains elusive. Here, we confirmed the upregulation ...
Source: Cancer Control - July 31, 2023 Category: Cancer & Oncology Authors: Yilin Zheng Yizhi Zhan Yuqin Zhang Yaowei Zhang Yang Liu Yuwen Xie Yining Sun Junying Qian Yanqing Ding Yi Ding Yuan Fang Source Type: research
Tacrolimus and Cyclosporin Pharmacotherapy, Detection Methods, Cytochrome P450 Enzymes after Heart Transplantation
CONCLUSION: Polypharmacy based on tacrolimus or cyclosporine needs vigilant therapeutic drug monitoring due to the cytochrome P450 enzymes associated with biochemical variables in metabolic pathways. Further attention to polypharmacy should be given to circulate drugs that could hide pharmacokinetics interactions associated with infections, malignancies, chronic kidney disease, and rejection after organ transplantation.PMID:37496131 | DOI:10.2174/1871525721666230726150021 (Source: Cardiovascular and Hematological Agents in Medicinal Chemistry)
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - July 27, 2023 Category: Cardiology Authors: Zahra Tolou-Ghamari Source Type: research
Evaluation of residual antibacterial effects on canine skin surface and hair following treatment with five commercial mousse products against Staphylococcus pseudintermedius
CONCLUSIONS AND CLINICAL RELEVANCE: The antibacterial effects of mousse 5 were not affected by hair length. Hair may be acceptable for evaluating effects on the skin in short-haired dogs. However, long hair may interfere with product distribution and duration of bacterial inhibition. Therefore, the evaluation of hair alone may overestimate clinically relevant antibacterial effects.PMID:37434336 | DOI:10.1111/vde.13190 (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - July 12, 2023 Category: Veterinary Research Authors: Chi-Yen Wu Rebecca Parsiola Mark Mitchell Maria Mitchell Sara Ramos Ivan Ravera Cherie Pucheu-Haston Source Type: research
Evidence for the Metabolic Activation of Deferasirox < em > In Vitro < /em > and < em > In Vivo < /em >
Chem Res Toxicol. 2023 Jul 12. doi: 10.1021/acs.chemrestox.2c00416. Online ahead of print.ABSTRACTDeferasirox (DFS) is used for the treatment of iron accumulation caused by the need for long-term blood transfusions, such as thalassemia or other rare anemia. Liver injury due to exposure to DFS has been documented, and the toxic mechanisms of DFS are unknown. The present study aimed to investigate the reactive metabolites of DFS in vitro and in vivo to help us understand the mechanisms of DFS hepatotoxicity. Two hydroxylated metabolites (5-OH and 5'-OH) were identified during incubation of DFS-supplemented rat liver microsom...
Source: Cell Research - July 12, 2023 Category: Cytology Authors: Mengdie Su Yanjia Zhao Mei Li Chenyang Jia He Liu Yue Zhang Weiwei Li Ying Peng Jiang Zheng Source Type: research
Evaluation of residual antibacterial effects on canine skin surface and hair following treatment with five commercial mousse products against Staphylococcus pseudintermedius
CONCLUSIONS AND CLINICAL RELEVANCE: The antibacterial effects of mousse 5 were not affected by hair length. Hair may be acceptable for evaluating effects on the skin in short-haired dogs. However, long hair may interfere with product distribution and duration of bacterial inhibition. Therefore, the evaluation of hair alone may overestimate clinically relevant antibacterial effects.PMID:37434336 | DOI:10.1111/vde.13190 (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - July 12, 2023 Category: Veterinary Research Authors: Chi-Yen Wu Rebecca Parsiola Mark Mitchell Maria Mitchell Sara Ramos Ivan Ravera Cherie Pucheu-Haston Source Type: research
Elucidation of the relationship between evodiamine-induced liver injury and CYP3A4-mediated metabolic activation by UPLC-MS/MS analysis
In this study, comprehensive hepatotoxicity evaluation was explored, which demonstrated that EVD caused hepatotoxicity in both time- and dose-dependent manners in mice. By application of UPLC-Q/TOF-MS/MS, two GSH conjugates (GM1 and GM2) derived from reactive metabolites of EVD were identified, in microsomal incubation systems exposed to EVD with glutathione (GSH) as trapping agents. CYP3A4 was proved to be the main metabolic enzyme. Correspondingly, the N-acetyl-L-cysteine conjugate derived from the degradation of GM2 was detected in the urine of mice after exposure to EVD. For the first time, the iminoquinone intermediat...
Source: Analytical and Bioanalytical Chemistry - July 11, 2023 Category: Chemistry Authors: Ting Peng Jinqiu Rao Tingting Zhang Yuan Wang Na Li Qing Gao Xinchi Feng Zhaohui Song Kai Wang Feng Qiu Source Type: research
Silver(I) complexes containing N-heterocyclic carbene azole drugs: Synthesis, characterization, cytotoxic activity, and their BSA interactions
J Inorg Biochem. 2023 Jun 23;246:112303. doi: 10.1016/j.jinorgbio.2023.112303. Online ahead of print.ABSTRACTCancer is one of the main public health problems globally, there is a public demand for better drugs. Rational strategies or approaches are used to improve the success of drug discovery. Our strategy was to the repurposing of well-known antifungal agents as potential anticancer drugs, such as Clotrimazole (CTZ) and Ketoconazole (KTZ). We prepared the respective iodide imidazolium salt L1: (CTZ-Me)I and L2: (KTZ-Me)I to be the intermediates toward the synthesis of its respective NHC ligand and achieve the respective ...
Source: Journal of Inorganic Biochemistry - July 6, 2023 Category: Biochemistry Authors: Camila Aparecida da Silva Dos Reis Cond é Ana Luiza de Andrade Querino Heveline Silva Maribel Navarro Source Type: research
