Design, Synthesis, Characterization, and Analysis of Antimicrobial Property of Novel Benzophenone Fused Azetidinone Derivatives through In Vitro and In Silico Approach
Curr Issues Mol Biol. 2022 Dec 23;45(1):92-109. doi: 10.3390/cimb45010007.ABSTRACTA sequence of novel 2-(4-benzoyl-2-methyl-phenoxy)-N-(3-chloro-2-oxo-4-phenyl-azetidin-1-yl)-acetamide analogues 9(a-n) were synthesized by multistep synthesis. The newly synthesized compounds were well characterized, and their antimicrobial activities were carried out by disc diffusion and broth dilution methods. Further, all the novel series of compounds (9a-n), were tested against a variety of bacterial and fungal strains in comparison to Ketoconazole, Chloramphenicol, and Amoxicillin as standard drugs, respectively. Compounds...
Source: Current Issues in Molecular Biology - January 20, 2023 Category: Molecular Biology Authors: Lakshmi Ranganatha Venkataravanappa Mahima Jyothi Hussien Ahmed Khamees Ekaterina Silina Victor Stupin Raghu Ram Achar Mohammed Al-Ghorbani Shaukath Ara Khanum Source Type: research
Design, Synthesis, Characterization, and Analysis of Antimicrobial Property of Novel Benzophenone Fused Azetidinone Derivatives through In Vitro and In Silico Approach
Curr Issues Mol Biol. 2022 Dec 23;45(1):92-109. doi: 10.3390/cimb45010007.ABSTRACTA sequence of novel 2-(4-benzoyl-2-methyl-phenoxy)-N-(3-chloro-2-oxo-4-phenyl-azetidin-1-yl)-acetamide analogues 9(a-n) were synthesized by multistep synthesis. The newly synthesized compounds were well characterized, and their antimicrobial activities were carried out by disc diffusion and broth dilution methods. Further, all the novel series of compounds (9a-n), were tested against a variety of bacterial and fungal strains in comparison to Ketoconazole, Chloramphenicol, and Amoxicillin as standard drugs, respectively. Compounds...
Source: Current Issues in Molecular Biology - January 20, 2023 Category: Molecular Biology Authors: Lakshmi Ranganatha Venkataravanappa Mahima Jyothi Hussien Ahmed Khamees Ekaterina Silina Victor Stupin Raghu Ram Achar Mohammed Al-Ghorbani Shaukath Ara Khanum Source Type: research
Design, Synthesis, Characterization, and Analysis of Antimicrobial Property of Novel Benzophenone Fused Azetidinone Derivatives through In Vitro and In Silico Approach
Curr Issues Mol Biol. 2022 Dec 23;45(1):92-109. doi: 10.3390/cimb45010007.ABSTRACTA sequence of novel 2-(4-benzoyl-2-methyl-phenoxy)-N-(3-chloro-2-oxo-4-phenyl-azetidin-1-yl)-acetamide analogues 9(a-n) were synthesized by multistep synthesis. The newly synthesized compounds were well characterized, and their antimicrobial activities were carried out by disc diffusion and broth dilution methods. Further, all the novel series of compounds (9a-n), were tested against a variety of bacterial and fungal strains in comparison to Ketoconazole, Chloramphenicol, and Amoxicillin as standard drugs, respectively. Compounds...
Source: Current Issues in Molecular Biology - January 20, 2023 Category: Molecular Biology Authors: Lakshmi Ranganatha Venkataravanappa Mahima Jyothi Hussien Ahmed Khamees Ekaterina Silina Victor Stupin Raghu Ram Achar Mohammed Al-Ghorbani Shaukath Ara Khanum Source Type: research
Design, Synthesis, Characterization, and Analysis of Antimicrobial Property of Novel Benzophenone Fused Azetidinone Derivatives through In Vitro and In Silico Approach
Curr Issues Mol Biol. 2022 Dec 23;45(1):92-109. doi: 10.3390/cimb45010007.ABSTRACTA sequence of novel 2-(4-benzoyl-2-methyl-phenoxy)-N-(3-chloro-2-oxo-4-phenyl-azetidin-1-yl)-acetamide analogues 9(a-n) were synthesized by multistep synthesis. The newly synthesized compounds were well characterized, and their antimicrobial activities were carried out by disc diffusion and broth dilution methods. Further, all the novel series of compounds (9a-n), were tested against a variety of bacterial and fungal strains in comparison to Ketoconazole, Chloramphenicol, and Amoxicillin as standard drugs, respectively. Compounds...
Source: Current Issues in Molecular Biology - January 20, 2023 Category: Molecular Biology Authors: Lakshmi Ranganatha Venkataravanappa Mahima Jyothi Hussien Ahmed Khamees Ekaterina Silina Victor Stupin Raghu Ram Achar Mohammed Al-Ghorbani Shaukath Ara Khanum Source Type: research
Design, Synthesis, Characterization, and Analysis of Antimicrobial Property of Novel Benzophenone Fused Azetidinone Derivatives through In Vitro and In Silico Approach
Curr Issues Mol Biol. 2022 Dec 23;45(1):92-109. doi: 10.3390/cimb45010007.ABSTRACTA sequence of novel 2-(4-benzoyl-2-methyl-phenoxy)-N-(3-chloro-2-oxo-4-phenyl-azetidin-1-yl)-acetamide analogues 9(a-n) were synthesized by multistep synthesis. The newly synthesized compounds were well characterized, and their antimicrobial activities were carried out by disc diffusion and broth dilution methods. Further, all the novel series of compounds (9a-n), were tested against a variety of bacterial and fungal strains in comparison to Ketoconazole, Chloramphenicol, and Amoxicillin as standard drugs, respectively. Compounds...
Source: Current Issues in Molecular Biology - January 20, 2023 Category: Molecular Biology Authors: Lakshmi Ranganatha Venkataravanappa Mahima Jyothi Hussien Ahmed Khamees Ekaterina Silina Victor Stupin Raghu Ram Achar Mohammed Al-Ghorbani Shaukath Ara Khanum Source Type: research
Transcriptional profiling of the developing rat ovary following intrauterine exposure to the endocrine disruptors diethylstilbestrol and ketoconazole
Arch Toxicol. 2023 Jan 18. doi: 10.1007/s00204-023-03442-2. Online ahead of print.ABSTRACTExposure to endocrine-disrupting chemicals (EDCs) during development may cause reproductive disorders in women. Although female reproductive endpoints are assessed in rodent toxicity studies, a concern is that typical endpoints are not sensitive enough to detect chemicals of concern to human health. If so, measured endpoints must be improved or new biomarkers of effects included. Herein, we have characterized the dynamic transcriptional landscape of developing rat ovaries exposed to two well-known EDCs, diethylstilbestrol (DES) and ke...
Source: Archives of Toxicology - January 18, 2023 Category: Toxicology Authors: Indusha Kugathas Hanna K L Johansson Edith Chan Sock Peng Maryne Toupin Bertrand Evrard Thomas A Darde Julie Boberg Monica K Draskau Antoine D Rolland S éverine Mazaud-Guittot Fr édéric Chalmel Terje Svingen Source Type: research
Transcriptional profiling of the developing rat ovary following intrauterine exposure to the endocrine disruptors diethylstilbestrol and ketoconazole
Arch Toxicol. 2023 Jan 18. doi: 10.1007/s00204-023-03442-2. Online ahead of print.ABSTRACTExposure to endocrine-disrupting chemicals (EDCs) during development may cause reproductive disorders in women. Although female reproductive endpoints are assessed in rodent toxicity studies, a concern is that typical endpoints are not sensitive enough to detect chemicals of concern to human health. If so, measured endpoints must be improved or new biomarkers of effects included. Herein, we have characterized the dynamic transcriptional landscape of developing rat ovaries exposed to two well-known EDCs, diethylstilbestrol (DES) and ke...
Source: Archives of Toxicology - January 18, 2023 Category: Toxicology Authors: Indusha Kugathas Hanna K L Johansson Edith Chan Sock Peng Maryne Toupin Bertrand Evrard Thomas A Darde Julie Boberg Monica K Draskau Antoine D Rolland S éverine Mazaud-Guittot Fr édéric Chalmel Terje Svingen Source Type: research
Transcriptional profiling of the developing rat ovary following intrauterine exposure to the endocrine disruptors diethylstilbestrol and ketoconazole
Arch Toxicol. 2023 Jan 18. doi: 10.1007/s00204-023-03442-2. Online ahead of print.ABSTRACTExposure to endocrine-disrupting chemicals (EDCs) during development may cause reproductive disorders in women. Although female reproductive endpoints are assessed in rodent toxicity studies, a concern is that typical endpoints are not sensitive enough to detect chemicals of concern to human health. If so, measured endpoints must be improved or new biomarkers of effects included. Herein, we have characterized the dynamic transcriptional landscape of developing rat ovaries exposed to two well-known EDCs, diethylstilbestrol (DES) and ke...
Source: Archives of Toxicology - January 18, 2023 Category: Toxicology Authors: Indusha Kugathas Hanna K L Johansson Edith Chan Sock Peng Maryne Toupin Bertrand Evrard Thomas A Darde Julie Boberg Monica K Draskau Antoine D Rolland S éverine Mazaud-Guittot Fr édéric Chalmel Terje Svingen Source Type: research
Molecules, Vol. 28, Pages 986: Rhamnopyranoside-Based Fatty Acid Esters as Antimicrobials: Synthesis, Spectral Characterization, PASS, Antimicrobial, and Molecular Docking Studies
mmed Mahbubul Matin
The most widely used and accessible monosaccharides have a number of stereogenic centers that have been hydroxylated and are challenging to chemically separate. As a result, the task of regioselective derivatization of such structures is particularly difficult. Considering this fact and to get novel rhamnopyranoside-based esters, DMAP-catalyzed di-O-stearoylation of methyl α-l-rhamnopyranoside (3) produced a mixture of 2,3-di-O- (4) and 3,4-di-O-stearates (5) (ratio 2:3) indicating the reactivity of the hydroxylated stereogenic centers of rhamnopyranoside as 3-OH > 4-OH &...
Source: Molecules - January 18, 2023 Category: Chemistry Authors: Abul Fazal Muhammad Sanaullah Puja Devi Takbir Hossain Sulaiman Bin Sultan Mohammad Mohib Ullah Badhon Md. Emdad Hossain Jamal Uddin Md. Abdul Majed Patwary Mohsin Kazi Mohammed Mahbubul Matin Tags: Article Source Type: research
GSE207094 Identification of Biomarkers and Outcomes of Endocrine Disruption in Human Ovarian Cortex using In Vitro Models
Contributors : Tianyi Li ; Anastasios Damdimopoulos ; Pauliina DamdimopoulouSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEndocrine disrupting chemicals (EDCs) are raising concerns about adverse effects on fertility in women. However, there is a lack of information regarding mechanisms of action and effects in humans. Our study aims to identify molecular mechanisms of endocrine disruption using two EDCs, diethylstilbestrol (DES) and ketoconazole (KTZ). Human ovarian cortical tissue obtained from Caesarean section patients were exposed to 10-9 M - 10-5 M KTZ and 10-10 M - 10-6 M D...
Source: GEO: Gene Expression Omnibus - January 11, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Molecules, Vol. 28, Pages 711: Fungicidal Activity of Zinc Oxide Nanoparticles against Azole-Resistant Aspergillus flavus Isolated from Yellow and White Maize
In this report, we isolated and identified azole-resistant A. flavus isolates from two sources of maize (white and yellow maize). The susceptibilities of Aspergillus flavus isolates were investigated by conventional antifungals such as Terbinfine, Fluconazole, Ketoconazole, Voricazole, Amphotericin, and Nystatin. Then zinc oxide nanoparticles associated with Chlorella vulgaris, which are synthesized by using the precipitation method, were examined against isolated fungi. The results showed that twelve species of white corn were isolated out of fifty isolates, while the number of isolates from the yellow corn source was onl...
Source: Molecules - January 11, 2023 Category: Chemistry Authors: Nuha M. Alhazmi Eman M. Sharaf Tags: Article Source Type: research
Ectopic adrenocorticotrophic hormone syndrome secondary to treatment-related neuroendocrine differentiation of metastatic castrate-resistant prostate cancer
Endocrinol Diabetes Metab Case Rep. 2023 Jan 1;2023:22-0347. doi: 10.1530/EDM-22-0347. Online ahead of print.ABSTRACTSUMMARY: A 64-year-old man with progressive metastatic castrate-resistant prostate adenocarcinoma presented with recurrent fluid overload, severe hypokalaemia with metabolic alkalosis and loss of glycaemic control. Clinical features were facial plethora, skin bruising and proximal myopathy. Plasma adrenocorticotrophic hormone (ACTH), serum cortisol and 24-h urinary cortisol levels were elevated. Low-dose dexamethasone failed to suppress cortisol. Pituitary MRI was normal and 68Gallium-DOTATATE PET-CT scan sh...
Source: Cancer Control - January 10, 2023 Category: Cancer & Oncology Authors: Chelsea Tan Jessica Triay Source Type: research
Physiologically-Based Pharmacokinetic Modeling to Predict Drug-drug Interactions of Dabigatran Etexilate and Rivaroxaban in the Chinese Older Adults
CONCLUSION: Aging and DDI increases exposure of drug in Chinese older adults. However, aging does not have a drastic impact on the extent of DDIs. Clinical management of DDIs in Chinese older adults in the absence of complex polypharmacy can a priori be similar to the EHRA guideline but routine monitoring of bleeding risk is encouraged when dabigatran etexilate given with verapamil and clarithromycin.PMID:36626944 | DOI:10.1016/j.ejps.2023.106376 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - January 10, 2023 Category: Drugs & Pharmacology Authors: Valerie Sia Jie En Xuan Lai Xinyi Wu Fan Zhang Haiyan Li Cheng Cui Dongyang Liu Source Type: research
Physiologically-Based Pharmacokinetic Modeling to Predict Drug-drug Interactions of Dabigatran Etexilate and Rivaroxaban in the Chinese Older Adults
CONCLUSION: Aging and DDI increases exposure of drug in Chinese older adults. However, aging does not have a drastic impact on the extent of DDIs. Clinical management of DDIs in Chinese older adults in the absence of complex polypharmacy can a priori be similar to the EHRA guideline but routine monitoring of bleeding risk is encouraged when dabigatran etexilate given with verapamil and clarithromycin.PMID:36626944 | DOI:10.1016/j.ejps.2023.106376 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - January 10, 2023 Category: Drugs & Pharmacology Authors: Valerie Sia Jie En Xuan Lai Xinyi Wu Fan Zhang Haiyan Li Cheng Cui Dongyang Liu Source Type: research
Identification of Biomarkers and Outcomes of Endocrine Disruption in Human Ovarian Cortex Using In Vitro Models
In conclusion, SCD may serve as a potential novel human-relevant biomarker of EDC exposure and effects on ovaries.PMID:36621641 | DOI:10.1016/j.tox.2023.153425 (Source: Toxicology)
Source: Toxicology - January 9, 2023 Category: Toxicology Authors: Tianyi Li Paraskevi Vazakidou Pim E G Leonards Anastasios Damdimopoulos Eleftheria Maria Panagiotou Catarina Arnelo Kerstin Jansson Karin Pettersson Kiriaki Papaikonomou Majorie van Duursen Pauliina Damdimopoulou Source Type: research
