Lipin-1 deficiency deteriorates defect of fatty acid β-oxidation and lipid-related kidney damage in diabetic kidney disease
This study aimed to explore the molecular mechanism of lipid metabolic regulation in kidney, especially renal PTECs, and elucidate the role of lipid metabolic related molecule lipin-1 in diabetic lipid-related kidney damage. In this study, lipin-1-deficient db/db mouse model and STZ/HFD-induced T2DM mouse model were used to determine the effect of lipin-1 on DKD development. (Source: Translational Research)
Source: Translational Research - July 9, 2023 Category: Research Authors: Simei Lin, Liang Wang, Yingli Jia, Ying Sun, Panshuang Qiao, Yazhu Quan, Jihan Liu, Huihui Hu, Baoxue Yang, Hong Zhou Source Type: research
N-acetylcysteine combined with insulin attenuates myocardial injury in canines with type 1 diabetes mellitus by modulating TNF- α-mediated apoptotic pathways and affecting linear ubiquitination
This study aims to explore the therapeutic effect and mechanism of N-acetylcysteine (NAC) combined with insulin on type 1 DM. (Source: Translational Research)
Source: Translational Research - July 6, 2023 Category: Research Authors: Jianjia Huang, Xiaoyue Pang, Xinting Zhang, Wenyue Qiu, Xuluan Zhang, Rongmei Wang, Wenting Xie, Yuman Bai, Shuilian Zhou, Jianzhao Liao, Zhaojun Xiong, Zhaoxin Tang, Rongsheng Su Source Type: research
Mitochondrial aspartate/glutamate carrier AGC1 regulates cardiac function via Drp1-mediated mitochondrial fission in doxorubicin-induced cardiomyopathy
This study investigated the therapeutic effects of the overexpression of glyoxalase I (GLO1), a detoxifying enzyme of gly cotoxins, on acute hyperglycemia–aggravated ischemic brain injury. In the present study, adeno-associated viral (AAV)-mediated GLO1 overexpression reduced infarct volume and edema level but did not improve neurofunctional recovery in the mice with middle cerebral artery occlusion (MCAO). (Source: Translational Research)
Source: Translational Research - July 5, 2023 Category: Research Authors: Kuan-Jung Lu, Chih-Hao Yang, Joen-Rong Sheu, Chi-Li Chung, Tanasekar Jayakumar, Chieh-Min Chen, Cheng-Ying Hsieh Source Type: research
Depleted Hexokinase1 and lack of AMPK α activation favor OXPHOS-dependent energetics in Retinoblastoma tumors
In this study, we demonstrate that loss of Hexokinase 1(HK1) in tumor cells rewires their metabolism allowing enhanced oxidative phosphorylation-dependent energy production. We show that rescuing HK1 or RB1 in these retinoblastoma cells reduced cancer hallmarks such as proliferation, invasion, spheroid formation and increased their sensitivity to chemotherapy drugs. (Source: Translational Research)
Source: Translational Research - July 5, 2023 Category: Research Authors: Vishnu Suresh Babu, Ashwin Mallipatna, Gagan Dudeja, Rohit Shetty, Archana Padmanabhan Nair, Sai Bo Bo Tun, Candice Ee Hua Ho, Shyam S Chaurasia, Shomi S Bhattacharya, Navin Kumar Verma, Rajamani Lakshminarayanan, Nilanjan Guha, Stephane Heymans, Velucham Source Type: research
Overexpressing Glyoxalase 1 Attenuates Acute Hyperglycemia –Exacerbated Neurological Deficits of Ischemic Stroke in Mice
This study investigated the therapeutic effects of the overexpression of glyoxalase 1 (GLO1), a detoxifying enzyme of glycot oxins, on acute hyperglycemia–aggravated ischemic brain injury. In present study, AAV-mediated GLO1 overexpression reduced infarct volume and edema level but did not improve neurofunctional recovery in the mice with MCAO. (Source: Translational Research)
Source: Translational Research - July 5, 2023 Category: Research Authors: Kuan-Jung Lu, Chih-Hao Yang, Joen-Rong Sheu, Chi-Li Chung, Tanasekar Jayakumar, Chieh-Min Chen, Cheng-Ying Hsieh Source Type: research
Mitochondrial aspartate/glutamate carrier AGC1 regulates cardiac function via Drp1-mediated mitochondrial fission in doxorubicin-induced cardiomyopathy
Mitochondrial fission has been noted in the pathogenesis of dilated cardiomyopathy (DCM), but the underlying specific regulatory mechanism, especially in the development of doxorubicin (DOX)-induced cardiomyopathy remains unclear. In the present study, we explore whether the aspartate-glutamate carrier1 (AGC1) interacts with the fission protein dynamin-related protein 1 (Drp1) and reveal the functional and molecular mechanisms contributing to DOX-induced cardiomyopathy. (Source: Translational Research)
Source: Translational Research - July 2, 2023 Category: Research Authors: Yan Xia, Jiayu Jin, Ao Chen, Danbo Lu, Xinyu Che, Jiaqi Ma, Su Li, Ming Yin, Zheng Yang, Hao Lu, Chenguang Li, Jinxiang Chen, Muyin Liu, Yuan Wu, Hui Gong, Yunzeng Zou, Zhangwei Chen, Juying Qian, Junbo Ge Source Type: research
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer
Head and neck cancers, which include oral squamous cell carcinoma (OSCC) as a major subsite, exhibit cellular plasticity that includes features of an epithelial-mesenchymal transition (EMT), referred to as partial-EMT (p-EMT). To identify molecular mechanisms contributing to OSCC plasticity, we performed a multiphase analysis of single cell RNA sequencing (scRNAseq) data from human OSCC. This included a multi-resolution characterization of cancer cell subgroups to identify pathways and cell states that are heterogeneously represented, followed by casual inference analysis to elucidate activating and inhibitory relationship...
Source: Translational Research - June 21, 2023 Category: Research Authors: Eric R. Reed, Stacy A. Jankowski, Anthony J. Spinella, Vikki Noonan, Robert Haddad, Kenichi Nomoto, Junji Matsui, Manish V. Bais, Xaralabos Varelas, Maria A. Kukuruzinska, Stefano Monti Source Type: research
Contents
(Source: Translational Research)
Source: Translational Research - June 17, 2023 Category: Research Source Type: research
Masthead
(Source: Translational Research)
Source: Translational Research - June 17, 2023 Category: Research Source Type: research
Editorial Advisory Board
(Source: Translational Research)
Source: Translational Research - June 17, 2023 Category: Research Source Type: research
Author Guidelines
(Source: Translational Research)
Source: Translational Research - June 17, 2023 Category: Research Source Type: research
Information for Readers
(Source: Translational Research)
Source: Translational Research - June 17, 2023 Category: Research Source Type: research
Contents
(Source: Translational Research)
Source: Translational Research - June 17, 2023 Category: Research Source Type: research
Topical delivery of mitogen-activated protein kinase inhibitor binimetinib prevents the development of cutaneous neurofibromas in neurofibromatosis type 1 mutant mice
Cutaneous neurofibromas (cNFs) are a hallmark of patients with the neurofibromatosis type 1 (NF1) genetic disorder. These benign nerve sheath tumors, which can amount to thousands, develop from puberty onward, often cause pain and are considered by patients to be the primary burden of the disease. Mutations of NF1, encoding a negative regulator of the RAS signaling pathway, in the Schwann cell (SCs) lineage are considered to be at the origin of cNFs. The mechanisms governing cNFs development are poorly understood, and therapeutics to reduce cNFs are missing, mainly due to the lack of appropriate animal models. (Source: Translational Research)
Source: Translational Research - June 16, 2023 Category: Research Authors: Fanny Coulpier, Pernelle Pulh, Layna Oubrou, Julie Naudet, Laura Fertitta, Jean-Marc Gregoire, Arnaud Bocquet, Anne-Marie Schmitt, Pierre Wolkenstein, Katarzyna J. Radomska, Piotr Topilko Source Type: research
Topical delivery of MEK inhibitor binimetinib prevents the development of cutaneous neurofibromas in Neurofibromatosis type 1 mutant mice
Cutaneous neurofibromas (cNFs) are a hallmark of patients with the neurofibromatosis type 1 (NF1) genetic disorder. These benign nerve sheath tumors, which can amount to thousands, develop from puberty onward, often cause pain and are considered by patients to be the primary burden of the disease. Mutations of NF1, encoding a negative regulator of the RAS signaling pathway, in the Schwann cell (SCs) lineage are considered to be at the origin of cNFs. The mechanisms governing cNFs development are poorly understood, and therapeutics to reduce cNFs are missing, mainly due to the lack of appropriate animal models. (Source: Translational Research)
Source: Translational Research - June 16, 2023 Category: Research Authors: F. Coulpier, P. Pulh, L. Oubrou, J. Naudet, L. Fertitta, J-M. Gregoire, A. Bocquet, A-M. Schmitt, P. Wolkenstein, KJ. Radomska, P Topilko Source Type: research
