The CXCR4-AT1 axis plays a vital role in glomerular injury via mediating the crosstalk between podocyte and mesangial cell
Glomeruli stand at the center of nephrons to accomplish filtration and albumin interception.Podocytes and mesangial cells are the major constituents in the glomeruli. However, their interdependency in glomerular injury has rarely been reported. Herein, we investigated the role of C-X-C chemokine receptor type 4 (CXCR4) in mediating the crosstalk between podocytes and mesangial cells. We found CXCR4 and angiotensin II (AngII) increased primarily in injured podocytes. However, type-1 receptor of angiotensin II (AT1) and stromal cell-derived factor 1 α (SDF-1α), a ligand of CXCR4, were evidently upregulated in mesangial cel...
Source: Translational Research - September 9, 2023 Category: Research Authors: Qinyu Wu, Shan Zhou, Dan Xu, Ping Meng, Qiurong Chen, Xiaoxu Wang, Xiaolong Li, Shuangqin Chen, Huiyun Ye, Wenting Ye, Yabing Xiong, Jiemei Li, Jinhua Miao, Weiwei Shen, Xu Lin, Fan Fan Hou, Youhua Liu, Yunfang Zhang, Lili Zhou Source Type: research
Upregulation of NOR-1 in calcified human vascular tissues: impact on osteogenic differentiation and calcification
Cardiovascular calcification is a significant public health issue whose pathophysiology is not fully understood. NOR-1 regulates critical processes in cardiovascular remodeling, but its contribution to ectopic calcification is unknown. NOR-1 was overexpressed in human calcific aortic valves and calcified atherosclerotic lesions colocalizing with RUNX2, a factor essential for osteochondrogenic differentiation and calcification. NOR-1 and osteogenic markers were upregulated in calcifying human valvular interstitial cells (VICs) and human vascular smooth muscle cells (VSMCs). (Source: Translational Research)
Source: Translational Research - September 8, 2023 Category: Research Authors: Carme Ballester-Servera, Laia Ca ñes, Judith Alonso, Lidia Puertas-Umbert, Paula Vázquez-Sufuentes, Manel Taurón, Elena Roselló-Díez, Francisco Marín, Cristina Rodríguez, José Martínez-González Source Type: research
Adenosinergic metabolism pathway: an emerging target for improving outcomes of solid organ transplantation
Extracellular nucleotides are widely recognized as crucial modulators of immune responses in peripheral tissues. ATP and adenosine are key components of extracellular nucleotides, the balance of which contributes to immune homeostasis. Under tissue injury, ATP exerts its pro-inflammatory function, while the adenosinergic pathway rapidly degrades ATP to immunosuppressive adenosine, thus inhibiting excessive and uncontrolled inflammatory responses. Previous reviews have explored the immunoregulatory role of extracellular adenosine in various pathological conditions, especially inflammation and malignancy. (Source: Translational Research)
Source: Translational Research - September 5, 2023 Category: Research Authors: Bingran Wang, Aiwei Zhou, Qi Pan, Yanran Li, Zhifeng Xi, Kang He, Dan Li, Bin Li, Yongbo Liu, Yuan Liu, Qiang Xia Source Type: research
Employing the sustained-release properties of poly(lactic-co-glycolic acid) nanoparticles to reveal a novel mechanism of sodium-hydrogen exchanger 1 in neuropathic pain
Neuropathic pain is caused by injury or disease of the somatosensory system, and its course is usually chronic. Several studies have been dedicated to investigating neuropathic pain-related targets; however, little attention has been paid to the persistent alterations that these targets, some of which may be crucial to the pathophysiology of neuropathic pain. The present study aimed to identify potential targets that may play a crucial role in neuropathic pain and validate their long-term impact. (Source: Translational Research)
Source: Translational Research - September 5, 2023 Category: Research Authors: Junhua Wu, Meiling Jin, Quangdon Tran, Minwoo Kim, Song I. Kim, Juhee Shin, Hyewon Park, Nara Shin, Hyunji Kang, Hyo Jung Shin, Sun Yeul Lee, Song-Biao Cui, C. Justin Lee, Won Hyung Lee, Dong Woon Kim Source Type: research
Calcium-sensing receptor activator cinacalcet for treatment of cyclic nucleotide-mediated secretory diarrheas
: Cyclic nucleotide elevation in intestinal epithelial cells is the key pathology causing intestinal fluid loss in secretory diarrheas such as cholera. Current secretory diarrhea treatment is primarily supportive, and oral rehydration solution is the mainstay of cholera treatment. There is an unmet need for safe, simple and effective diarrhea treatments. By promoting cAMP hydrolysis, extracellular calcium-sensing receptor (CaSR) is a regulator of intestinal fluid transport. (Source: Translational Research)
Source: Translational Research - September 5, 2023 Category: Research Authors: Tifany Chu, Pattareeya Yottasan, Livia de Souza Goncalves, Apurva A. Oak, Ruxian Lin, Ming Tse, Mark Donowitz, Onur Cil Source Type: research
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Source: Translational Research - August 25, 2023 Category: Research Source Type: research
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Source: Translational Research - August 25, 2023 Category: Research Source Type: research
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Source: Translational Research - August 25, 2023 Category: Research Source Type: research
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Source: Translational Research - August 25, 2023 Category: Research Source Type: research
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Source: Translational Research - August 25, 2023 Category: Research Source Type: research
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Source: Translational Research - August 25, 2023 Category: Research Source Type: research
Multi-dimensional metabolomic profiling reveals dysregulated ornithine metabolism hallmarks associated with a severe acute pancreatitis phenotype
To reveal dysregulated metabolism hallmark that was associated with a severe acute pancreatitis (SAP) phenotype. (Source: Translational Research)
Source: Translational Research - August 22, 2023 Category: Research Authors: Jinxi Yang, Na Shi, Shisheng Wang, Manjiangcuo Wang, Yan Huang, Yiqin Wang, Ge Liang, Juqin Yang, Juan Rong, Yun Ma, Lan Li, Ping Zhu, Chenxia Han, Tao Jin, Hao Yang, Wei Huang, Daniel Raftery, Qing Xia, Dan Du Source Type: research
Transcription factor EBF1 mitigates neuropathic pain by rescuing Kv1.2 expression in primary sensory neurons
In this study, we examined whether early B cell factor 1 (EBF1), a transcription factor, in the DRG participated in neuropathic pain caused by chronic constriction injury (CCI) of the sciatic nerve. EBF1 was distributed exclusively in neuronal nucleus and co-expressed with cytoplasmic/membrane Kv1.2 in individual DRG neurons. (Source: Translational Research)
Source: Translational Research - August 20, 2023 Category: Research Authors: Yingping Liang, Dilip Sharma, Bing Wang, Huixing Wang, Xiaozhou Feng, Ruining Ma, Tolga Berkman, Steven Char, Alex Bekker, Yuan-Xiang Tao Source Type: research
Extensive therapeutic effects, underlying molecular mechanisms and disease treatment prediction of Metformin: a systematic review
Metformin, a first-line management for Type 2 Diabetes Mellitus, has been expansively employed and studied with results indicating its therapeutic potential extending beyond glycaemic control. Beyond its established role, this therapeutic drug demonstrates a broad spectrum of action encompassing over sixty disorders, encompassing metabolic conditions, inflammatory disorders, carcinomas, cardiovascular diseases, and cerebrovascular pathologies. There is clear evidence of metformin's action targeting specific nodes in the molecular pathways of these diseases and, intriguingly, interactions with the intestinal microbiota and ...
Source: Translational Research - August 9, 2023 Category: Research Authors: Yifei Geng, Zhen Wang, Xiaoyu Xu, Xiao Sun, Xi Dong, Yun Luo, Xiaobo Sun Tags: Review Article Source Type: research
The rare circulating tumor microemboli as a biomarker contributes to predicting early colorectal cancer recurrences after medical treatment
This study evaluated the rare circulating tumor microemboli (CTM) from liquid biopsy individually and together with circulating tumor cells (CTCs) and serum CEA/CA19-9 in a panel, on early prediction of colorectal cancer (CRC) recurrence. Stained CTCs/CTM were detected by a microfluidic chip-based automatic rare-cell imaging platform. ROC, AUC, Kaplan-Meier survival, and Cox proportional hazard models regarding 4 selected biomarkers were analyzed. (Source: Translational Research)
Source: Translational Research - August 7, 2023 Category: Research Authors: Yun-Jie Hao, Lu-Wey Chang, Chih-Yung Yang, Liang-Chuan Lo, Chien-Ping Lin, Yuan-Wei Jian, Jeng-Kai Jiang, Fan-Gang Tseng Source Type: research
