Reversal of cisplatin resistance in oral squamous cell carcinoma by piperlongumine loaded smart nanoparticles through inhibition of Hippo-YAP signaling pathway
Cisplatin alone or in combination with 5FU and docetaxel is the preferred chemotherapy regimen for advanced-stage OSCC patients. However, its use has been linked to recurrence and metastasis due to the development of drug resistance. Therefore, sensitization of cancer cells to conventional chemotherapeutics can be an effective strategy to overcome drug resistance. Piperlongumine, an alkaloid, have shown anticancer properties and sensitizes numerous neoplasms, but its effect on OSCC has not been explored. (Source: Translational Research)
Source: Translational Research - March 16, 2024 Category: Research Authors: Pratikshya Sa, Priya Singh, Sudhakar Panda, Rajeeb K. Swain, Rupesh Dash, Sanjeeb Kumar Sahoo Source Type: research
Genetic and pharmacological targeting of XBP1 alleviates hepatic ischemia reperfusion injury by enhancing FoxO1-dependent mitophagy
In this study, we aimed to investigate the effects and the underlying mechanism of XBP1 in the progression of hepatic I/R injury. Hepatocyte-specific XBP1 knockout mice, multiple viral delivery systems and specific pharmacological inhibitors were applied in vivo in a partial hepatic I/R injury mouse model and in vitro in a cell model of hypoxia-reoxygenation (H/R) injury. (Source: Translational Research)
Source: Translational Research - March 15, 2024 Category: Research Authors: Baicheng Kuang, Mengqin Wang, Hao Yan, Qin Jiang, Zhiheng Wang, Haiqiang Ni, Shuaiheng Hou, Xuan Peng, Shiqi Gu, Yuanyuan Zhao, Tongwen Ou, Nianqiao Gong Source Type: research
The pregnancy-associated protein glycodelin as a potential sex-specific target for resistance to immunotherapy in non-small cell lung cancer
Lung cancer has been shown to be targetable by novel immunotherapies which reactivate the immune system and enable tumor cell killing. However, treatment failure and resistance to these therapies is common. Consideration of sex as a factor influencing therapy resistance is still rare. We hypothesize that the success of the treatment is impaired by the presence of the immunosuppressive pregnancy-associated glycoprotein glycodelin that is expressed in patients with non-small-cell lung cancer (NSCLC). (Source: Translational Research)
Source: Translational Research - March 13, 2024 Category: Research Authors: Sarah Richtmann, Sebastian Marwitz, Thomas Muley, Hannu Koistinen, Petros Christopoulos, Michael Thomas, Daniel Kazdal, Michael Allg äuer, Hauke Winter, Torsten Goldmann, Michael Meister, Ursula Klingmüller, Marc A. Schneider Source Type: research
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Source: Translational Research - March 9, 2024 Category: Research Source Type: research
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Source: Translational Research - March 9, 2024 Category: Research Source Type: research
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Source: Translational Research - March 9, 2024 Category: Research Source Type: research
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Source: Translational Research - March 9, 2024 Category: Research Source Type: research
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Source: Translational Research - March 9, 2024 Category: Research Source Type: research
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Source: Translational Research - March 9, 2024 Category: Research Source Type: research
PCSK9 inhibition protects mice from food allergy
The Proprotein Convertase Subtilisin Kexin of type 9 (PCSK9) has been identified in 2003 as the third gene involved in familial hypercholesterolemia. PCSK9 binds to the membrane low-density lipoprotein receptor (LDLR) and promotes its cellular internalization and lysosomal degradation. Beyond this canonical role, PCSK9 was recently described to be involved in several immune responses. However, to date, the contribution of PCSK9 in food allergy remains unknown. Here, we showed that Pcsk9 deficiency or pharmacological inhibition of circulating PCSK9 with a specific monoclonal antibody (m-Ab) protected mice against symptoms o...
Source: Translational Research - March 9, 2024 Category: Research Authors: Victoria Lorant, Martin Klein, Damien Gar çon, Thibaud Sotin, Samuel Frey, Marie-Aude Cheminant, Audrey Ayer, Mikaël Croyal, Laurent Flet, Antoine Rimbert, Luc Colas, Bertrand Cariou, Grégory Bouchaud, Cédric Le May Source Type: research
Arginine methylation and respiratory disease
Arginine methylation, a vital post-translational modification, plays a pivotal role in numerous cellular functions such as signal transduction, DNA damage response and repair, regulation of gene transcription, mRNA splicing, and protein interactions. Central to this modification is the role of protein arginine methyltransferases (PRMTs), which have been increasingly recognized for their involvement in the pathogenesis of various respiratory diseases. This review begins with an exploration of the biochemical underpinnings of arginine methylation, shedding light on the intricate molecular regulatory mechanisms governed by PR...
Source: Translational Research - March 5, 2024 Category: Research Authors: Binbin Zhang, Youhong Guan, Daxiong Zeng, Ran Wang Tags: Review Article Source Type: research
RAS protein activator-like 2 (RASAL2) initiates peritubular capillary rarefaction in hypoxic renal interstitial fibrosis
The progression of chronic kidney disease (CKD) often involves renal interstitial fibrosis (RIF) and subsequent loss of peritubular capillaries (PTCs), which enhances disease severity. Despite advancements in our understanding of fibrosis, effective interventions for reversing capillary loss remain elusive. Notably, RIF exhibits reduced capillary density, whereas renal cell carcinoma (RCC) shows robust angiogenesis under hypoxic conditions. Using RNA sequencing and bioinformatics, we identified differentially expressed genes (DEGs) in hypoxic human renal tubular epithelial cells (HK-2) and renal cancer cells (786-0). (Sour...
Source: Translational Research - March 5, 2024 Category: Research Authors: Yu Zhang, Yiqiong Yang, Xiuxiu Hu, Bizhen Wei, Qian Shen, Chuanbing Shi, Pingsheng Chen Source Type: research
Inhibition of G protein-coupled receptor 68 using homoharringtonine attenuates chronic kidney disease-associated cardiac impairment
Chronic kidney disease (CKD) induces cardiac inflammation and fibrosis and reduces survival. We previously demonstrated that G protein-coupled receptor 68 (GPR68) promotes cardiac inflammation and fibrosis in mice with 5/6 nephrectomy (5/6Nx) and patients with CKD. However, no method of GPR68 inhibition has been found that has potential for therapeutic application. Here, we report that Cephalotaxus harringtonia var. nana extract and homoharringtonine ameliorate cardiac inflammation and fibrosis under CKD by suppressing GPR68 function. (Source: Translational Research)
Source: Translational Research - February 22, 2024 Category: Research Authors: Yuya Yoshida, Kohei Fukuoka, Miyu Sakugawa, Masayuki Kurogi, Kengo Hamamura, Keika Hamasaki, Fumiaki Tsurusaki, Kurumi Sotono, Takumi Nishi, Taiki Fukuda, Taisei Kumamoto, Kosuke Oyama, Takashi Ogino, Akito Tsuruta, Kouta Mayanagi, Tomohiro Yamashita, Hir Source Type: research
Ntsr1 contributes to pulmonary hypertension by enhancing endoplasmic reticulum stress via JAK2-STAT3-Thbs1 signaling
Pulmonary hypertension (PH) is a severe clinical syndrome with pulmonary vascular remodeling and poor long-term prognosis. Neurotensin receptor 1 (Ntsr1), serve as one of the G protein-coupled receptors (GPCRs), implicates in various biological processes, but the potential effects of Ntsr1 in PH development are unclear. The Sugen/Hypoxia (SuHx) or monocrotaline (MCT) induced rat PH model was used in our study and the PH rats showed aggravated pulmonary artery remodeling and increased right ventricular systolic pressure (RVSP). (Source: Translational Research)
Source: Translational Research - February 21, 2024 Category: Research Authors: Zhi-xing Wei, Xing-xing Cai, Yu-dong Fei, Qian wang, Xiao-liang Hu, Cheng Li, Jian-wen Hou, Yu-li Yang, Yue-peng Wang, Yi-Gang Li Source Type: research
Characterization of the Plasma Proteomic Profile of Fabry Disease: Potential Sex- and Clinical Phenotype-specific Biomarkers
Fabry disease (FD) is a X-linked rare lysosomal storage disorder caused by deficient α-galactosidase A (α-GalA) activity. Early diagnosis and the prediction of disease course are complicated by the clinical heterogeneity of FD, as well as by the frequently inconclusive biochemical and genetic test results that do not correlate with clinical course. We sought to identify potential biomarkers of FD to better understand the underlying pathophysiology and clinical phenotypes. We compared the plasma proteomes of 50 FD patients and 50 matched healthy controls using DDA and SWATH-MS. (Source: Translational Research)
Source: Translational Research - February 21, 2024 Category: Research Authors: Laura L ópez-Valverde, María E. Vázquez-Mosquera, Cristóbal Colón-Mejeras, Susana B. Bravo, Sofía Barbosa-Gouveia, J. Víctor Álvarez, Rosario Sánchez-Martínez, Manuel López-Mendoza, Mónica López-Rodríguez, Eduardo Villacorta-Argüelles, Mar Source Type: research
