Genetic and pharmacological targeting of XBP1 alleviates hepatic ischemia reperfusion injury by enhancing FoxO1-dependent mitophagy

In this study, we aimed to investigate the effects and the underlying mechanism of XBP1 in the progression of hepatic I/R injury. Hepatocyte-specific XBP1 knockout mice, multiple viral delivery systems and specific pharmacological inhibitors were applied in vivo in a partial hepatic I/R injury mouse model and in vitro in a cell model of hypoxia-reoxygenation (H/R) injury.

Source: Translational Research - March 15, 2024 Category: Research Authors: Baicheng Kuang, Mengqin Wang, Hao Yan, Qin Jiang, Zhiheng Wang, Haiqiang Ni, Shuaiheng Hou, Xuan Peng, Shiqi Gu, Yuanyuan Zhao, Tongwen Ou, Nianqiao Gong Source Type: research