Retinol binding protein 4 promotes the phenotypic transformation of vascular smooth muscle cells under high glucose condition via modulating RhoA/ROCK1 pathway
This study is performed to clarify the biological function of RBP4 in modulating the phenotypic switch of VSMCs induced via RhoA/ROCK1 signaling pathway. (Source: Translational Research)
Source: Translational Research - March 29, 2023 Category: Research Authors: Wan Zhou, Xiaojing Yuan, Jie Li, Wei Wang, Shandong Ye Source Type: research
Rabies virus glycoprotein 29 (RVG29) promotes CAR-T immunotherapy for glioma
Chimeric antigen receptor T cell (CAR-T) therapy has limited efficacy for treating glioma because of the infiltrative nature of the blood –brain barrier (BBB) and T cell exhaustion. Conjugation with rabies virus glycoprotein (RVG) 29 enhances the brain-related efficacy of various agents. Here we assess whether RVG enhances the ability of CAR-T cells to cross the BBB and improves their immunotherapy. We generated 70R CAR-T cells (ant i-CD70 CAR-T modified with RVG29) and validated their tumor-killing efficacy in vitro and in vivo. (Source: Translational Research)
Source: Translational Research - March 25, 2023 Category: Research Authors: Feng Ji, Luxia Xu, Kaili Long, Fan Zhang, Miaomiao Zhang, Xiao Lu, Mingyue Xia, Jiannan Chen, Yu Du, Yong Tang, Heming Wu, Yan Shi, Ruiting Ma, Jun Li, Zhengliang Chen, Bin Xu, Qi zhang, Junqing Liang, Shaochang Jia, Zhigang Hu, Zhigang Guo Source Type: research
Purinergic receptor P2X7 contributes to abdominal aortic aneurysm development via modulating macrophage pyroptosis and inflammation
In this study, we demonstrate that P2X7 plays essential roles in AAA development via modulating macrophage pyroptosis and inflammation. P2X7 is highly expressed in human AAA specimen, as well as in experimental murine AAA lesions (both CaCl2- and Angiotensin II-induced AAA models), and it mainly confines in macrophages. (Source: Translational Research)
Source: Translational Research - March 24, 2023 Category: Research Authors: Likun Sun, Xin Li, Zhongchen Luo, Maohua Li, Hongyu Liu, Zhaowei Zhu, Junwei Wang, Peng Lu, Lunchang Wang, Chenzi Yang, Tun Wang, Hao He, Ming Li, Chang Shu, Jiehua Li Source Type: research
Purinergic Receptor P2 × 7 Contributes to Abdominal Aortic Aneurysm Development via Modulating Macrophage Pyroptosis and Inflammation
In this study, we demonstrate that P2 × 7 plays essential roles in A AA development via modulating macrophage pyroptosis and inflammation. P2 × 7 is highly expressed in human AAA specimen, as well as in experimental murine AAA lesions (both CaCl2-and Angiotensin Ⅱ-induced AAA models), and it mainly confines in macrophages. (Source: Translational Research)
Source: Translational Research - March 24, 2023 Category: Research Authors: Likun Sun, Xin Li, Zhongchen Luo, Maohua Li, Hongyu Liu, Zhaowei Zhu, Junwei Wang, Peng Lu, Lunchang Wang, Chenzi Yang, Tun Wang, Hao He, Ming Li, Chang Shu, Jiehua Li Source Type: research
Targeting Mutant Dicer Tumorigenesis in Pleuropulmonary Blastoma via Inhibition of RNA Polymerase I
DICER1 mutations predispose to increased risk for various cancers, particularly pleuropulmonary blastoma (PPB), the commonest lung malignancy of childhood. There is a paucity of directly actionable molecular targets as these tumors are driven by loss-of-function mutations of DICER1. Therapeutic development for PPB is further limited by a lack of biologically and physiologically-representative disease models. Given recent evidence of Dicer's role as a haploinsufficient tumor suppressor regulating RNA polymerase I (Pol I), Pol I inhibition could abrogate mutant Dicer-mediated accumulation of stalled polymerases to trigger ap...
Source: Translational Research - March 13, 2023 Category: Research Authors: Megan Rui En Wong, Kia Hui Lim, Esther Xuan Yi Hee, Huiyi Chen, Chik Hong Kuick, Aw Sze Jet, Kenneth Tou En Chang, Nurfarhanah Syed Sulaiman, Sharon YY Low, Septian Hartono, Anh Nguyen Tuan Tran, Summaiyya Hanum Ahamed, Ching Mei Joyce Lam, Shui Yen Soh, Source Type: research
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Source: Translational Research - February 28, 2023 Category: Research Source Type: research
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Source: Translational Research - February 28, 2023 Category: Research Source Type: research
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Source: Translational Research - February 28, 2023 Category: Research Source Type: research
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Source: Translational Research - February 28, 2023 Category: Research Source Type: research
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Source: Translational Research - February 28, 2023 Category: Research Source Type: research
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Source: Translational Research - February 28, 2023 Category: Research Source Type: research
Deep next-generation proteomics and network analysis reveal systemic and tissue-specific patterns in Fabry disease
Fabry disease (FD) is an X-linked lysosomal rare disease due to a deficiency of α-galactosidase A activity. The accumulation of glycosphingolipids mainly affects the kidney, heart, and central nervous system, considerably reducing life expectancy. Although the accumulation of undegraded substrate is considered the primary cause of FD, it is established that secondary dysfuncti ons at the cellular, tissue, and organ levels ultimately give rise to the clinical phenotype. To parse this biological complexity, a large-scale deep plasma targeted proteomic profiling has been performed. (Source: Translational Research)
Source: Translational Research - February 27, 2023 Category: Research Authors: Abdellah Tebani, Fr édéric Barbey, Olivier Dormond, Franklin Ducatez, Stéphane Marret, Albina Nowak, Soumeya Bekri Source Type: research
Elabela-APJ axis mediates angiogenesis via YAP/TAZ pathway in cerebral ischemia/reperfusion injury
Angiogenesis helps to improve neurological recovery by repairing damaged brain tissue and restoring cerebral blood flow (CBF). The role of the Elabela (ELA)-Apelin receptor (APJ) system in angiogenesis has gained much attention. We aimed to investigate the function of endothelial ELA on post-ischemic cerebral angiogenesis. Here, we demonstrated that the endothelial ELA expression was upregulated in the ischemic brain and treatment with ELA-32 mitigated brain injury and enhanced the restoration of CBF and newly formed functional vessels following cerebral ischemia/reperfusion (I/R) injury. (Source: Translational Research)
Source: Translational Research - February 20, 2023 Category: Research Authors: Wenyu Li, Pengfei Xu, Lingqi Kong, Shuo Feng, Nan Shen, Hongmei Huang, Wuxuan Wang, Xiang Xu, Xinyue Wang, Guoping Wang, Yan Zhang, Wen Sun, Wei Hu, Xinfeng Liu Source Type: research
CRISPR/Cas9-mediated A4GALT suppression rescues Fabry disease phenotypes in a kidney organoid model
The objective of this study was to investigate whether CRISPR/Cas9-mediated suppression of A4GALT could rescue phenotype of Fabry disease nephropathy (FDN) using human induced pluripotent stem cells (hiPSCs) derived kidney organoid system. We generated FDN patient-derived hiPSC (CMC-Fb-002) and FD-specific hiPSCs (GLA-KO) by knock-out (KO) of GLA in wild-type (WT) hiPSCs using CRISPR/Cas9. We then performed A4GALT KO in both CMC-Fb-002 and GLA-KO to make Fb-002-A4GALT-KO and GLA/A4GALT-KO, respectively. (Source: Translational Research)
Source: Translational Research - February 17, 2023 Category: Research Authors: Sheng Cui, Yoo Jin Shin, Xianying Fang, Hanbi Lee, Sang Hun Eum, Eun Jeong Ko, Sun Woo Lim, Eunji Shin, Kang In Lee, Jae Young Lee, Chae Bin Lee, Soo Kyung Bae, Chul Woo Yang, Byung Ha Chung Source Type: research
Apolipoprotein M/sphingosine 1-phosphate protects against diabetic nephropathy
Diabetic nephropathy remains a common cause of end-stage renal failure and its associated mortality around the world. Sphingosine 1-phosphate (S1P) is a multifunctional lipid mediator and binds to HDL via apolipoprotein M (ApoM). Since HDL has been reported to be epidemiologically associated with kidney disease, we attempted to investigate the involvement of the ApoM/S1P axis in the pathogenesis/progression of diabetic nephropathy. In type 2 diabetic patients, the serum ApoM levels were inversely correlated with the clinical stage of diabetic nephropathy. (Source: Translational Research)
Source: Translational Research - February 16, 2023 Category: Research Authors: Makoto Kurano, Kazuhisa Tsukamoto, Tomo Shimizu, Masumi Hara, Yutaka Yatomi Source Type: research