Pin1 and Alzheimer's Disease
Alzheimer's disease (AD) is an immense and growing public health crisis. Despite over 100 years of investigation, the etiology remains elusive and therapy ineffective. Despite current gaps in knowledge, recent studies have identified dysfunction or loss-of-function of Pin1, a unique cis-trans peptidyl prolyl isomerase, as an important step in AD pathogenesis. Here I review the functionality of Pin1 and its role in neurodegeneration. (Source: Translational Research)
Source: Translational Research - September 22, 2022 Category: Research Authors: James S. Malter Tags: Review Article Source Type: research
Inflammasome signaling in colorectal cancer
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths in the world. Inflammation is often an underlying risk factor for developing CRC. Maintaining gut homeostasis and balancing inflammation is therefore critical to prevent CRC development. One major component of gut homeostasis is inflammasomes, cytosolic multiprotein immune complexes that assemble upon sensing various intracellular alterations. Inflammasomes regulate inflammation, cell death, and various cellular processes. (Source: Translational Research)
Source: Translational Research - September 20, 2022 Category: Research Authors: Bhesh Raj Sharma, Thirumala-Devi Kanneganti Source Type: research
Development of Strategies for Community Engaged Research Dissemination by Basic Scientists: A Case Study
As depicted in the translational research continuum, dissemination of research findings to past research participants and the community-at-large is integral to improving health outcomes. Blocks in translation exist in which poor dissemination is a major contributor. Limited progress has been made on how to engage basic scientists at T1 and T2 phases to meaningfully disseminate study findings to community. Our objective is to report on four cases of community engaged research dissemination activities among 3 basic scientists (i.e., a cancer biologist, a biochemist, and a molecular biologist.): a townhall, a radio listening ...
Source: Translational Research - September 12, 2022 Category: Research Authors: Elizabeth C. Stewart, Jamaine S. Davis, Treniqka S. Walters, Zhenbang Chen, Stephania T. Miller, Jillian M. Duke, Leah R. Alexander, Rose Russell, Nicole Rowan, Lanese Campbell, Ira Baxter, Sondrea Tolbert, Jennifer Cunningham Erves Source Type: research
Establishment of a human 3D pancreatic adenocarcinoma model based on a patient-derived extracellular matrix scaffold
Pancreatic cancer is likely to become one of the leading causes of cancer-related death in many countries within the next decade. Surgery is the potentially curative treatment for pancreatic ductal adenocarcinoma (PDAC), although only 10 –20% of patients have a resectable disease after diagnosis. Despite recent advances in curative surgery the current prognosis ranges from 6 to 10% globally. One of the main issues at the pre-clinical level is the lacking of model which simultaneously reflects the tumour microenvironment (TME) at b oth structural and cellular levels. (Source: Translational Research)
Source: Translational Research - September 9, 2022 Category: Research Authors: Francesca Sensi, Edoardo D'Angelo, Andrea Biccari, Asia Marangio, Giulia Battisti, Sara Crotti, Matteo Fassan, Cecilia Laterza, Monica Giomo, Nicola Elvassore, Gaya Spolverato, Salvatore Pucciarelli, Marco Agostini Source Type: research
Tumor suppressor role of RBM22 in prostate cancer acting as a dual-factor regulating alternative splicing and transcription of key oncogenic genes.
Prostate cancer (PCa) is one the leading causes of cancer-related deaths among men. Consequently, the identification of novel molecular targets for treatment is urgently needed to improve patients ’ outcomes. Our group recently reported that some elements of the cellular machinery controlling alternative-splicing might be useful as potential novel therapeutic tools against advanced PCa. However, the presence and functional role of RBM22, a key spliceosome component, in PCa remains unknown. Therefore, RBM22 levels were firstly interrogated in three human cohorts and two preclinical mouse models (TRAMP/Pbsn-Myc). (Source: ...
Source: Translational Research - September 8, 2022 Category: Research Authors: Juan M Jim énez-Vacas, Antonio J Montero-Hidalgo, Enrique Gómez-Gómez, Prudencio Sáez-Martínez, Antonio C Fuentes-Fayos, Adrià Closa, Teresa González-Serrano, Ana Martínez-López, Rafael Sánchez-Sánchez, Pedro P López-Casas, André Sarmento-Cab Source Type: research
SIK2 protects against renal tubular injury and the progression of diabetic kidney disease
Despite optimal medical therapy, many patients with diabetic kidney disease (DKD) progress to end-stage renal disease. The identification of new biomarkers and drug targets for DKD is required for the development of more effective therapies. The apoptosis of renal tubular epithelial cells is a key feature of the pathogenicity associated with DKD. SIK2, a salt-inducible kinase, regulates important biological processes, such as energy metabolism, cell cycle progression and cellular apoptosis. In our current study, a notable decrease in the expression of SIK2 was detected in the renal tubules of DKD patients and murine models...
Source: Translational Research - September 5, 2022 Category: Research Authors: Bingyao Liu, Linlin Zhang, Hang Yang, Xinyu Chen, Hongting Zheng, Xiaoyu Liao Source Type: research
Inflammasome Activation in Traumatic Brain Injury and Alzheimer's Disease
Traumatic brain injury (TBI) and Alzheimer's disease (AD) represent two of the largest sources of death and disability in the United States. Recent studies have identified TBI as a potential risk factor for AD development, and numerous reports have shown that TBI is linked with AD associated protein expression during the acute phase of injury, suggesting an interplay between the two pathologies. The inflammasome is a multi-protein complex that plays a role in both TBI and AD pathologies, and is characterized by inflammatory cytokine release and pyroptotic cell death. (Source: Translational Research)
Source: Translational Research - September 4, 2022 Category: Research Authors: Nathan H. Johnson, Juan Pablo de Rivero Vaccari, Helen M. Bramlett, Robert W. Keane, W. Dalton Dietrich Source Type: research
Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Disease
Age is the most important risk factor for cardiovascular disease and appears to be more than a marker of cumulative exposure to other risk factors such as dyslipidemia and hypertension. With aging, genetic mutations occur that are not present in our germline DNA, observed as somatic mosaicism. Hematopoietic stem cells have an increased chance of developing mosaicism because they are highly proliferative, and mutations with survival benefits can establish clonal populations. Age-related clonal hematopoiesis resulting from somatic mutations was first described ∼25 years ago. (Source: Translational Research)
Source: Translational Research - September 2, 2022 Category: Research Authors: Seyedmohammad Saadatagah, Christie M. Ballantyne Tags: Review Article Source Type: research
Connectome-based biophysics models of Alzheimer ’s disease diagnosis and prognosis
With the increasing prevalence of Alzheimer ’s disease (AD) among aging populations and the limited therapeutic options available to slow or reverse its progression, the need has never been greater for improved diagnostic tools for identifying patients in the preclinical and prodomal phases of AD. Biophysics models of the connectome-based s pread of amyloid-beta (Aβ) and microtubule-associated protein tau (τ) have enjoyed recent success as tools for predicting the time course of AD-related pathological changes. (Source: Translational Research)
Source: Translational Research - August 28, 2022 Category: Research Authors: Justin Torok, Chaitali Anand, Parul Verma, Ashish Raj Source Type: research
Targeting tumor-associated MUC1 overcomes anoikis-resistance in pancreatic cancer
The third leading cause of cancer-related deaths in the United States is pancreatic cancer, more than 95% of which is Pancreatic Ductal Adenocarcinoma (PDA). The incidence rate of PDA nearly matches its mortality rate and the best treatment till date is surgical resection for which only 25% are eligible. Tumor recurrence and metastasis are the main causes of cancer-related mortality. MUC1 is a transmembrane glycoprotein expressed on most epithelial cells. It is overexpressed and aberrantly glycosylated in cancer and is known as tumor-associated MUC1 (tMUC1). (Source: Translational Research)
Source: Translational Research - August 28, 2022 Category: Research Authors: Mukulika Bose, Alexa Sanders, Chandrav De, Ru Zhou, Priyanka Lala, Sophia Shwartz, Bhaskar Mitra, Cory Brouwer, Pinku Mukherjee Source Type: research
The NLRP3 inflammasome fires up heme-induced inflammation in hemolytic conditions
Overactive inflammatory responses are central to the pathophysiology of many hemolytic conditions including sickle cell disease. Excessive hemolysis leads to elevated serum levels of heme due to saturation of heme scavenging mechanisms. Extracellular heme has been shown to activate the NLRP3 inflammasome leading to activation of caspase-1 and release of pro-inflammatory cytokines IL-1 β and IL-18. Heme also activates the non-canonical inflammasome pathway which may contribute to NLRP3 inflammasome formation and leads to pyroptosis, a type of inflammatory cell death. (Source: Translational Research)
Source: Translational Research - August 27, 2022 Category: Research Authors: Suruchi Salgar, Beatriz E Bol ívar, Jonathan M Flanagan, Shaniqua J Anum, Lisa Bouchier-Hayes Tags: Review Article Source Type: research
Contents
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Source: Translational Research - August 26, 2022 Category: Research Source Type: research
Masthead
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Source: Translational Research - August 26, 2022 Category: Research Source Type: research
Editorial Advisory Board
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Source: Translational Research - August 26, 2022 Category: Research Source Type: research
Author Guidelines
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Source: Translational Research - August 26, 2022 Category: Research Source Type: research
