Contents
(Source: Translational Research)
Source: Translational Research - January 13, 2024 Category: Research Source Type: research
Masthead
(Source: Translational Research)
Source: Translational Research - January 13, 2024 Category: Research Source Type: research
Editorial Advisory Board
(Source: Translational Research)
Source: Translational Research - January 13, 2024 Category: Research Source Type: research
Author Guidelines
(Source: Translational Research)
Source: Translational Research - January 13, 2024 Category: Research Source Type: research
Information for Readers
(Source: Translational Research)
Source: Translational Research - January 13, 2024 Category: Research Source Type: research
Contents
(Source: Translational Research)
Source: Translational Research - January 13, 2024 Category: Research Source Type: research
Cardiac-Specific Overexpression of CREM-Ib ΔC-X via CRISPR/Cas9 in Mice Presents a New Model of Atrial Cardiomyopathy with Spontaneous Atrial Fibrillation
Atrial cardiomyopathy (ACM) forms the substrate for atrial fibrillation (AF) and underlies the potential for atrial thrombus formation and subsequent stroke. However, generating stable animal models that accurately replicate the entire progression of atrial lesions, particularly the onset of AF, presents significant challenges. In the present study, we found that the isoform of CRE-binding protein modulator (CREM-Ib ΔC-X), which is involved in the regulation of cardiac development and atrial rhythm, was highly expressed in atrial biopsies from patients with AF. (Source: Translational Research)
Source: Translational Research - January 8, 2024 Category: Research Authors: Jiuzhou Chen, Huiyuan Qin, Jingzhe Hao, Qing Wang, Shaojie Chen, Gang Yang, Mingfang Li, Xiyu Zhu, Dongjin Wang, Hongwu Chen, Chang Cui, Minglong Chen Source Type: research
Heterogeneous Nuclear Ribonucleoprotein F Deficiency in Mouse Podocyte Promotes Podocytopathy Mediated by Methyltransferase-like 14 Nuclear Translocation Resulting in Sirtuin-1 Gene Inhibition
Heterogeneous nuclear ribonucleoprotein F (HnRNP F) is a key regulator for nucleic acid metabolism; however, whether HnRNP F expression is important in maintaining podocyte integrity is unclear. Nephroseq analysis from a registry of human kidney biopsies was performed. Age- and sex-matched podocyte-specific HnRNP F knockout (HnRNP FPOD KO) mice and control (HnRNP Ffl/fl) were studied. Podocytopathy was induced in male mice (more susceptible) either by adriamycin (ADR)- or low-dose streptozotocin treatment for 2 or 8 weeks. (Source: Translational Research)
Source: Translational Research - January 7, 2024 Category: Research Authors: Min-Chun Liao, Chao-Sheng Lo, Yu-Chao Pang, Wen-Xia Yang, Ke Su, Xin-Ping Zhao, Kana N. Miyata, Junzheng Peng, Julie R. Ingelfinger, John S.D. Chan, Shao-Ling Zhang Source Type: research
Aldehyde Dehydrogenase 2 Serves as a Key Cardiometabolic Adaptation Regulator in Response to Plateau Hypoxia in Mice
This study aims to determine the effects of plateau hypoxia (PH) on cardiac metabolism and function, investigate the associated role of ALDH2, and explore potential therapeutic targets. (Source: Translational Research)
Source: Translational Research - January 3, 2024 Category: Research Authors: Rifeng Gao, Kun Yang, Shiguan Le, Hanchuan Chen, Xiaolei Sun, Zhen Dong, Pingjin Gao, Xilu Wang, Jiaran Shi, Yanan Qu, Xiang Wei, Kai Hu, Jiucun Wang, Li Jin, Yi Li, Junbo Ge, Aijun Sun Source Type: research
Contents
(Source: Translational Research)
Source: Translational Research - December 16, 2023 Category: Research Source Type: research
Masthead
(Source: Translational Research)
Source: Translational Research - December 16, 2023 Category: Research Source Type: research
Editorial Advisory Board
(Source: Translational Research)
Source: Translational Research - December 16, 2023 Category: Research Source Type: research
Author Guidelines
(Source: Translational Research)
Source: Translational Research - December 16, 2023 Category: Research Source Type: research
Information for Readers
(Source: Translational Research)
Source: Translational Research - December 16, 2023 Category: Research Source Type: research
Contents
(Source: Translational Research)
Source: Translational Research - December 16, 2023 Category: Research Source Type: research
