Myeloid-derived suppressor cells ameliorate Corneal Alkali Burn through IL-10-dependent anti-inflammatory properties
To investigate the efficiency and the underlying mechanism of myeloid-derived suppressor cells (MDSCs) in corneal alkali burns (CAB). (Source: Translational Research)
Source: Translational Research - August 3, 2023 Category: Research Authors: Yichen Xiao, Jing Zhong, Jiahui Yang, Zhenyuan Fu, Bowen Wang, Lulu Peng, Xin Zuo, Xuan Zhao, Dalian He, Jin Yuan Source Type: research
Artificial intelligence-assisted repurposing of lubiprostone alleviates tubulointerstitial fibrosis
In this study, we investigated the antifibrotic effect of the machine learning-based repurposed drug, lubiprostone, validated through an advanced proximal tubule on a chip system and in vivo UUO mice model. (Source: Translational Research)
Source: Translational Research - August 2, 2023 Category: Research Authors: Anupama Samantasinghar, Faheem Ahmed, Chethikkattuveli Salih Abdul Rahim, Kyung Hwan Kim, Sejong Kim, Kyung Hyun Choi Source Type: research
Artificial Intelligence Assisted Repurposing of Lubiprostone Alleviates Tubulointerstitial Fibrosis.
In this study, we investigated the anti-fibrotic effect of the machine learning-based repurposed drug, Lubiprostone, validated through an advanced proximal tubule on a chip system and in vivo UUO mice model. (Source: Translational Research)
Source: Translational Research - August 2, 2023 Category: Research Authors: Anupama Samantasinghar, Faheem Ahmed, Chethikkattuveli Salih Abdul Rahim, Kyung Hwan Kim, Sejong Kim, Kyung Hyun Choi Source Type: research
Dual-regulation by Cx32 in hepatocyte to trigger and worsen liver graft injury
This study aimed to investigate the role of connexin32 (Cx32) in liver graft injury and elucidate its mechanism of action. (Source: Translational Research)
Source: Translational Research - July 25, 2023 Category: Research Authors: Fei Huang, Zhizhao Deng, Qian Zhang, Zheng Zhang, Xianlong Li, Weiqi Zeng, Yanling Wang, Ziqing Hei, Dongdong Yuan Source Type: research
Plasma protein signatures reflect systemic immunity and allograft function in kidney transplantation
Kidney transplantation causes large perturbations of the immune system. While many studies focus on the allograft, insights into systemic effects are largely missing. Here, we analyzed the systemic immune response in three cohorts of kidney transplanted patients. Using serum proteomics, laboratory values, mass cytometry, histological and clinical parameters, inter-patient heterogeneity was leveraged for multi-omic co-variation analysis. We identified circulating immune modules (CIM) that describe extra-renal signatures of co-regulated plasma proteins. (Source: Translational Research)
Source: Translational Research - July 25, 2023 Category: Research Authors: Konrad Buscher, Rebecca Rixen, Paula Sch ütz, Birte Hüchtmann, Veerle van Marck, Barbara Heitplatz, Ulrich Jehn, Daniela A. Braun, Gert Gabriels, Hermann Pavenstädt, Stefan Reuter Source Type: research
Noninvasive early differential diagnosis and progression monitoring of ovarian cancer using the copy number alterations of plasma cell-free DNA
Ovarian cancer (OV) is the most lethal gynecological malignancy and requires improved early detection methods and more effective intervention to achieve a better prognosis. The lack of sensitive and noninvasive biomarkers with clinical utility remains a challenge. Here, we conducted a genome-wide copy number variation (CNV) profiling analysis using low-coverage whole genome sequencing (LC-WGS) of plasma cfDNA in patients with non-malignant and malignant ovarian tumors, and identified 10 malignancy-specific and 12 late-stage-specific CNV markers from plasma cfDNA LC-WGS data. (Source: Translational Research)
Source: Translational Research - July 25, 2023 Category: Research Authors: Lu Chen, Rong Ma, Chang Luo, Qin Xie, Xin Ning, Kaidi Sun, Fanling Meng, Meng Zhou, Jie Sun Source Type: research
Synthetic surfactant with a combined SP-B and SP-C analogue is efficient in rabbit models of adult and neonatal respiratory distress syndrome
Respiratory distress syndrome (RDS) in premature infants is caused by insufficient amounts of endogenous lung surfactant and is efficiently treated with replacement therapy using animal-derived surfactant preparations. On the other hand, adult/acute RDS (ARDS) occurs secondary to e.g., sepsis, aspiration of gastric contents, and multitrauma and is caused by alveolar endothelial damage, leakage of plasma components into the airspaces and inhibition of surfactant activity. Instillation of surfactant preparations in ARDS has so far resulted in very limited treatment effects, partly due to inactivation of the delivered surfact...
Source: Translational Research - July 25, 2023 Category: Research Authors: Pavol Mikolka, Nina Kronqvist, Marie Haegerstrand-Bj örkman, Kristaps Jaudzems, Petra Kosutova, Maros Kolomaznik, Mihkel Saluri, Michael Landreh, Andrea Calkovska, Tore Curstedt, Jan Johansson Source Type: research
Contents
(Source: Translational Research)
Source: Translational Research - July 19, 2023 Category: Research Source Type: research
Masthead
(Source: Translational Research)
Source: Translational Research - July 19, 2023 Category: Research Source Type: research
Editorial Advisory Board
(Source: Translational Research)
Source: Translational Research - July 19, 2023 Category: Research Source Type: research
Author Guidelines
(Source: Translational Research)
Source: Translational Research - July 19, 2023 Category: Research Source Type: research
Information for Readers
(Source: Translational Research)
Source: Translational Research - July 19, 2023 Category: Research Source Type: research
Contents
(Source: Translational Research)
Source: Translational Research - July 19, 2023 Category: Research Source Type: research
Lipin-1 deficiency deteriorates defect of fatty acid β-oxidation and lipid-related kidney damage in diabetic kidney disease
This study aimed to explore the molecular mechanism of lipid metabolic regulation in kidney, especially renal PTECs, and elucidate the role of lipid metabolic related molecule lipin-1 in diabetic lipid-related kidney damage. In this study, lipin-1-deficient db/db mouse model and STZ/HFD-induced T2DM mouse model were used to determine the effect of lipin-1 on DKD development. (Source: Translational Research)
Source: Translational Research - July 9, 2023 Category: Research Authors: Simei Lin, Liang Wang, Yingli Jia, Ying Sun, Panshuang Qiao, Yazhu Quan, Jihan Liu, Huihui Hu, Baoxue Yang, Hong Zhou Source Type: research
N-acetylcysteine combined with insulin attenuates myocardial injury in canines with type 1 diabetes mellitus by modulating TNF- α-mediated apoptotic pathways and affecting linear ubiquitination
This study aims to explore the therapeutic effect and mechanism of N-acetylcysteine (NAC) combined with insulin on type 1 DM. (Source: Translational Research)
Source: Translational Research - July 6, 2023 Category: Research Authors: Jianjia Huang, Xiaoyue Pang, Xinting Zhang, Wenyue Qiu, Xuluan Zhang, Rongmei Wang, Wenting Xie, Yuman Bai, Shuilian Zhou, Jianzhao Liao, Zhaojun Xiong, Zhaoxin Tang, Rongsheng Su Source Type: research
