Vascular Contributions to Alzheimer's Disease
Alzheimer's disease (AD) is the most common cause of dementia and is characterized by progressive neurodegeneration and cognitive decline. Understanding the pathophysiology underlying AD is paramount for the management of individuals at risk of and suffering from AD. The vascular hypothesis stipulates a relationship between cardiovascular disease and AD-related changes although the nature of this relationship remains unknown. In this review, we discuss several potential pathological pathways of vascular involvement in AD that have been described including dysregulation of neurovascular coupling, disruption of the blood bra...
Source: Translational Research - December 15, 2022 Category: Research Authors: Laura B. Eisenmenger, Anthony Peret, Bolanle M. Famakin, Alma Spahic, Grant S. Roberts, Jeremy H. Bockholt, Kevin M. Johnson, Jane S. Paulsen Tags: Review Article Source Type: research
A new 165-SNP low-density lipoprotein cholesterol polygenic risk score based on next generation sequencing outperforms previously published scores in routine diagnostics of familial hypercholesterolemia
Genetic diagnosis of familial hypercholesterolemia (FH) remains unexplained in 30 to 70% of patients after exclusion of monogenic disease. There is now a growing evidence that a polygenic burden significantly modulates LDL-cholesterol (LDL-c) concentrations. Several LDL-c polygenic risk scores (PRS) have been set up. However, the balance between their diagnosis performance and their practical use in routine practice is not clearly established. Consequently, we set up new PRS based on our routine panel for sequencing and compared their diagnostic performance with previously-published PRS. (Source: Translational Research)
Source: Translational Research - December 14, 2022 Category: Research Authors: Xavier Vanhoye, Claire Bardel, Antoine Rimbert, Philippe Moulin, Pierre-Antoine Rollat-Farnier, Manon Muntaner, Oriane Marmontel, Sabrina Dumont, Sybil Charri ère, François Cornélis, Pierre Henri Ducluzeau, Annie Fonteille, Estelle Nobecourt, Noël Per Source Type: research
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Source: Translational Research - December 13, 2022 Category: Research Source Type: research
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Source: Translational Research - December 13, 2022 Category: Research Source Type: research
Editorial Advisory Board
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Source: Translational Research - December 13, 2022 Category: Research Source Type: research
Author Guidelines
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Source: Translational Research - December 13, 2022 Category: Research Source Type: research
Information for Readers
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Source: Translational Research - December 13, 2022 Category: Research Source Type: research
Contents
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Source: Translational Research - December 13, 2022 Category: Research Source Type: research
Breastfeeding by chikungunya virus-infected dams confers resistance to challenge in the offspring
Vertical transmission of Chikungunya virus (CHIKV) has been reported in humans, but the transmission routes have not been completely understood, and experimental animal models are needed to enable detailed investigation of the transmission and pathogenesis of congenital infections. The intertwining of immune response and virus components at the gestation/breastfeeding interfaces between mother and fetus/newborn may have effects during the offspring development. An experimental model of CHIKV was established by infecting pregnant BALB/c female mice that enabled confirmation that dams inoculated up to the 10th gestational da...
Source: Translational Research - December 13, 2022 Category: Research Authors: Juliano de Paula Souza, Bruna Lais Santos de Jesus, Andr é Luíz Giusti, Rosa Maria Mendes Viana, Ricardo de Souza Cardoso, Gláucia Maria Almeida, Marjorie Cornejo Pontelli, Beate Mareike, Danillo Lucas Alves Espósito, Danilo Machado de Melo, Thaís Me Source Type: research
A human vascularized microtumor model of patient-derived colorectal cancer recapitulates clinical disease
Accurately modeling tumor biology and testing novel therapies on patient-derived cells is critically important to developing therapeutic regimens personalized to a patient's specific disease. The vascularized microtumor (VMT), or "tumor-on-a-chip," is a physiologic preclinical cancer model that incorporates key features of the native human tumor microenvironment within a transparent microfluidic platform, allowing rapid drug screening in vitro. Herein we optimize methods for generating patient-derived VMT (pVMT) using fresh colorectal cancer (CRC) biopsies and surgical resections to test drug sensitivities at the individua...
Source: Translational Research - December 5, 2022 Category: Research Authors: Stephanie J. Hachey, Agua Sobrino, John G. Lee, Mehraneh D. Jafari, Samuel J. Klempner, Eric J. Puttock, Robert A. Edwards, John S. Lowengrub, Marian L. Waterman, Jason A. Zell, Christopher C.W. Hughes Source Type: research
A Human Vascularized Micro-Tumor Model of Patient-Derived Colorectal Cancer Recapitulates Clinical Disease
Accurately modeling tumor biology and testing novel therapies on patient-derived cells is critically important to developing therapeutic regimens personalized to a patient's specific disease. The vascularized micro-tumor (VMT), or "tumor-on-a-chip", is a physiologic preclinical cancer model that incorporates key features of the native human tumor microenvironment within a transparent microfluidic platform, allowing rapid drug screening in vitro. Herein we optimize methods for generating patient-derived VMT (pVMT) using fresh colorectal cancer (CRC) biopsies and surgical resections to test drug sensitivities at the individu...
Source: Translational Research - December 5, 2022 Category: Research Authors: Stephanie J. Hachey, Agua Sobrino, John G. Lee, Mehraneh D. Jafari, Samuel J. Klempner, Eric J. Puttock, Robert A. Edwards, John S. Lowengrub, Marian L. Waterman, Jason A. Zell, Christopher C.W. Hughes Source Type: research
Neutrophil Extracellular Traps Induce Abdominal Aortic Aneurysm Formation by Promoting the Synthetic and Proinflammatory Smooth Muscle Cell Phenotype via Hippo-YAP Pathway
The neutrophil plays an important role during abdominal aortic aneurysm (AAA) formation by undergoing histone citrullination with peptidyl arginine deiminase 4 (encoded by Padi4) and releasing neutrophil extracellular traps (NETs). However, the specific role of NETs during AAA formation is elusive. We found the levels of NET components in serum and tissues were found to be significantly associated with the clinical outcome of AAA patients. Furthermore, we reported that NETs induced the synthetic and proinflammatory smooth muscle cells (SMCs) phenotype and promoted AAA formation in a Hippo-YAP pathway-dependent manner by in...
Source: Translational Research - November 23, 2022 Category: Research Authors: Shuofei Yang, Liang Chen, Zheyu Wang, Jiaquan Chen, Qihong Ni, Xiangjiang Guo, Wanfeng Liu, Lei Lv, Guanhua Xue Source Type: research
Contents
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Source: Translational Research - November 19, 2022 Category: Research Source Type: research
Masthead
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Source: Translational Research - November 19, 2022 Category: Research Source Type: research
Editorial Advisory Board
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Source: Translational Research - November 19, 2022 Category: Research Source Type: research
