ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression
Aberrant N6-methyladenosine (m6A) modification of mRNAs contributes significantly to the epigenetic tumorigenesis, however, its precise role and the key targets in osteosarcoma (OS) are not defined. Here we reported that selective METTL3 (methyltransferase like 3) elevation and the consequential increase of m6A modification causally affect OS progression. The fast-growing OS cells displayed preferential upregulation of METTL3 and increased m6A modification. Conversely, m6A inhibition by 3-deazaadenosine, siRNA-mediated METTL3 knockdown or a METTL3-selective inhibitor by STM2457 effectively inhibits OS cell growth and induc...
Source: Translational Research - April 28, 2023 Category: Research Authors: Xueying An, Wenshu Wu, Lin Yang, Jian Dong, Bin Liu, Junxia Guo, Jianmei Chen, Baosheng Guo, Wangsen Cao, Qing Jiang Source Type: research
A key role for NLRP3 signaling in preterm labor and birth driven by the alarmin S100B
Preterm birth remains the leading cause of neonatal morbidity and mortality worldwide. A substantial number of spontaneous preterm births occur in the context of sterile intra-amniotic inflammation, a condition that has been mechanistically proven to be triggered by alarmins. However, sterile intra-amniotic inflammation still lacks treatment. The NLRP3 inflammasome has been implicated in sterile intra-amniotic inflammation; yet, its underlying mechanisms, as well as the maternal and fetal contributions to this signaling pathway, are unclear. (Source: Translational Research)
Source: Translational Research - April 28, 2023 Category: Research Authors: Jose Galaz, Kenichiro Motomura, Roberto Romero, Zhenjie Liu, Valeria Garcia-Flores, Li Tao, Yi Xu, Bogdan Done, Marcia Arenas-Hernandez, Tomi Kanninen, Marcelo Farias-Jofre, Derek Miller, Adi L. Tarca, Nardhy Gomez-Lopez Source Type: research
Role of MicroRNAs in Arrhythmogenic Cardiomyopathy: translation as biomarkers into clinical practice
Arrhythmogenic cardiomyopathy is a rare inherited entity, characterized by a progressive fibro-fatty replacement of the myocardium. It leads to malignant arrhythmias and a high risk of sudden cardiac death. Incomplete penetrance and variable expressivity are hallmarks of this arrhythmogenic cardiac disease, where the first manifestation may be syncope and sudden cardiac death, often triggered by physical exercise. Early identification of individuals at risk is crucial to adopt protective and ideally personalized measures to prevent lethal episodes. (Source: Translational Research)
Source: Translational Research - April 24, 2023 Category: Research Authors: Mireia Alcalde, Roc ío Toro, Fernando Bonet, José Córdoba-Caballero, Estefanía Martínez-Barrios, Juan Antonio Ranea, Marta Vallverdú-Prats, Ramon Brugada, Viviana Meraviglia, Milena Bellin, Georgia Sarquella-Brugada, Oscar Campuzano Tags: Review Article Source Type: research
Diabetes Mellitus and Aortic Stenosis head to head: toward personalized medicine in patients with both pathologies
Diabetes mellitus (DM) and calcific aortic stenosis (CAS) are common morbidities in the elderly, which are both chronic, progressive and often concomitant diseases. Several studies revealed that DM increases the risk of developing severe CAS, yet clear information about the relationship between both these diseases and the influence of DM on the progression of CAS is currently lacking. To evaluate the effect of DM on aortic valves and on the process of calcification, and to achieve better patient management in daily clinical practice, we analysed calcified and non-calcified valve tissue from patients with severe CAS, with o...
Source: Translational Research - April 19, 2023 Category: Research Authors: Nerea Corbacho-Alonso, Tamara Sastre-Oliva, Luis F. L ópez-Almodovar, Jorge Solis, Luis R. Padial, Teresa Tejerina, Montserrat Carrascal, Laura Mourino-Alvarez, Maria G. Barderas Source Type: research
Contents
(Source: Translational Research)
Source: Translational Research - April 12, 2023 Category: Research Source Type: research
Masthead
(Source: Translational Research)
Source: Translational Research - April 12, 2023 Category: Research Source Type: research
Editorial Advisory Board
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Source: Translational Research - April 12, 2023 Category: Research Source Type: research
Author Guidelines
(Source: Translational Research)
Source: Translational Research - April 12, 2023 Category: Research Source Type: research
Information for Readers
(Source: Translational Research)
Source: Translational Research - April 12, 2023 Category: Research Source Type: research
Contents
(Source: Translational Research)
Source: Translational Research - April 12, 2023 Category: Research Source Type: research
Computational drug repositioning of clopidogrel as a novel therapeutic option for focal segmental glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) is a glomerular lesion often associated with nephrotic syndrome. It is also associated with a high risk of progression to end-stage kidney disease. Current treatment of FSGS is limited to systemic corticosteroids or calcineurin inhibition, along with inhibitors of the renin-angiotensin-aldosterone system. FSGS is heterogeneous in etiology, and novel therapies targeting specific, dysregulated molecular pathways represent a major unmet medical need. We have generated a network-based molecular model of FSGS pathophysiology using previously established systems biology workflows to allo...
Source: Translational Research - April 12, 2023 Category: Research Authors: Christoph A. Gebeshuber, Lisa Daniel-Fischer, Heinz Regele, Helga Schachner, Christoph Aufricht, Christoph Kornauth, Matthias Ley, Seth L. Alper, Rebecca Herzog, Klaus Kratochwill, Paul Perco Source Type: research
Contents
(Source: Translational Research)
Source: Translational Research - April 5, 2023 Category: Research Source Type: research
Masthead
(Source: Translational Research)
Source: Translational Research - April 5, 2023 Category: Research Source Type: research
Editorial Advisory Board
(Source: Translational Research)
Source: Translational Research - April 5, 2023 Category: Research Source Type: research
Author Guidelines
(Source: Translational Research)
Source: Translational Research - April 5, 2023 Category: Research Source Type: research
