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(Source: Translational Research)
Source: Translational Research - February 7, 2024 Category: Research Source Type: research
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Source: Translational Research - February 7, 2024 Category: Research Source Type: research
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Source: Translational Research - February 7, 2024 Category: Research Source Type: research
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Source: Translational Research - February 7, 2024 Category: Research Source Type: research
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Source: Translational Research - February 7, 2024 Category: Research Source Type: research
Contents
(Source: Translational Research)
Source: Translational Research - February 7, 2024 Category: Research Source Type: research
Nebulized Platelet-Derived Extracellular Vesicles Attenuate Chronic Cigarette Smoke-Induced Murine Emphysema
In this study, a murine model of CS-induced emphysema was used to determine whether nebulized PEP can influence the development of CS-induced emphysema through the mitigation of oxidative stress and inflammation in the lung. (Source: Translational Research)
Source: Translational Research - February 5, 2024 Category: Research Authors: Weixia Xuan, Shaohua Wang, Amarilys Alarcon-Calderon, Monique Simone Bagwell, Rachel Para, Faping Wang, Chujie Zhang, Xue Tian, Paul Stalboerger, Timothy Peterson, Michael Sabbah, Zeji Du, Tiffany Sarrafian, Ryan Mahlberg, Matt Hillestad, Skylar A. Rizzo, Source Type: research
Targeting a cardiac abundant and fibroblasts-specific piRNA (CFRPi) to attenuate and reverse cardiac fibrosis in pressure-overloaded heart failure
Cardiac fibrosis under chronic pressure overload is an end-stage adverse remodeling of heart. However, current heart failure treatments barely focus on anti-fibrosis and the effects are limited. We aimed to seek for a cardiac abundant and cardiac fibrosis specific piRNA, exploring its underlying mechanism and therapeutic potential. Whole transcriptome sequencing and the following verification experiments identified a highly upregulated piRNA (piRNA-000691) in transverse aortic constriction (TAC) mice, TAC pig, and heart failure human samples, which was abundant in heart and specifically expressed in cardiac fibroblasts. (S...
Source: Translational Research - February 1, 2024 Category: Research Authors: Bo Chen, Bozhong Shi, Zijie Zhou, Yue Cui, Guowei Zeng, Lingyan Cheng, Xiaoyang Zhang, Kai Luo, Cong Li, Zhongqun Zhu, Zhifang Zhang, Jinghao Zheng, Xiaomin He Source Type: research
Reducing SULT2B1 promotes the interaction of LncRNAgga3-204 with SMAD4 to inhibit the macrophage inflammatory response and delay atherosclerosis progression
This study aims to investigate the impact of sulfotransferase family 2b member 1 (SULT2B1) on the inflammatory response of macrophages and the progression of AS. Here, we reported that SULT2B1 expression increased with the progression of AS. In AS model mice, knockdown of Sult2b1 led to remission of AS and reduced inflammation levels. Further exploration of the downstream molecular mechanisms of SULT2B1 revealed that suppressing Sult2b1 in macrophages resulted in decreased levels of 25HC3S in the nucleus, elevated expression of Lxr, and increased the transcription of Lncgga3-204. (Source: Translational Research)
Source: Translational Research - January 27, 2024 Category: Research Authors: Hangyu Pan, Tongwei Wu, Kang Huang, Zhongzhou Guo, Hongbin Liang, Ping Lyu, Hui Huang, Xinyi Feng, Qianqian Wang, Jing Hu, Yihua He, Zhigang Guo, Mengzhuo Yin, Yanan Zhang Source Type: research
Metabolic reprogramming driven by METTL1-mediated tRNA m7G modification promotes acquired anlotinib resistance in oral squamous cell carcinoma
Tyrosine kinase inhibitors (TKIs) are frequently utilized in the management of malignant tumors. Studies have indicated that anlotinib has a significant inhibitory effect on oral squamous cell carcinoma (OSCC). However, the mechanisms underlying the development of resistance with long-term anlotinib treatment remain obscure. Our research found that METTL1 expression was heightened in anlotinib-resistant OSCC cells. We observed that METTL1 played a role in fostering resistance to anlotinib in both transgenic mouse models and in vitro. (Source: Translational Research)
Source: Translational Research - January 25, 2024 Category: Research Authors: Jie Chen, Qimin Zhou, Shuai Li, Rongsong Ling, Yiwei Zhao, Demeng Chen, Anxun Wang, Yang Cao Source Type: research
Chronic kidney disease and left ventricular diastolic dysfunction (ckd-lvdd) alter cardiac expression of mitochondria-related genes in swine
Cardiovascular disease and heart failure doubles in patients with chronic kidney disease (CKD), but the underlying mechanisms remain obscure. Mitochondria are central to maintaining cellular respiration and modulating cardiomyocyte function. We took advantage of our novel swine model of CKD and left ventricular diastolic dysfunction (CKD-LVDD) to investigate the expression of mitochondria-related genes and potential mechanisms regulating their expression. CKD-LVDD and normal control pigs (n=6/group, 3 males/3 females) were studied for 14 weeks. (Source: Translational Research)
Source: Translational Research - January 21, 2024 Category: Research Authors: Alejandro R. Chade, Rhys Sitz, Taylor J. Kelty, Elizabeth McCarthy, Darla L. Tharp, R. Scott Rector, Alfonso Eirin Source Type: research
Enhancing Axonal Myelination: Clemastine Attenuates Cognitive Impairment in a Rat Model of Diffuse Traumatic Brain Injury
Traumatic brain injury (TBI) has a significant impact on cognitive function, affecting millions of people worldwide. Myelin loss is a prominent pathological feature of TBI, while well-functioning myelin is crucial for memory and cognition. Utilizing drug repurposing to identify effective drug candidates for TBI treatment has gained attention. Notably, recent research has highlighted the potential of clemastine, an FDA-approved allergy medication, as a promising pro-myelinating drug. Therefore, in this study, we aim to investigate whether clemastine can enhance myelination and alleviate cognitive impairment following mild T...
Source: Translational Research - January 19, 2024 Category: Research Authors: Zhihai Huang, Yu Feng, Yulan Zhang, Xiaohui Ma, Xuemei Zong, J. Dedrick Jordan, Quanguang Zhang Source Type: research
Astrocyte-derived exosomes-transported miRNA-26a-5p ameliorates sevoflurane-induced cognitive dysfunction in aged mice
Prolonged sevoflurane anesthesia is the primary factor contributing to the development of perioperative neurocognitive disorders (PND). Recent studies have highlighted neuronal apoptosis and abnormal dendritic structures as crucial features of PND. Astrocytes-derived exosomes (ADEs) have been identified as carriers of microRNAs (miRNAs), playing a vital role in cell-to-cell communication through transmitting genetic material. Nevertheless, the specific mechanisms by which miRNAs in ADEs contribute to sevoflurane-induced cognitive deficit are currently unknown. (Source: Translational Research)
Source: Translational Research - January 18, 2024 Category: Research Authors: Junhua Li, Hui Xu, Kun Zhang, Yafang Liu, Cong Zeng, Yanni Fu, Yujuan Li Source Type: research
Active AKT2 stimulation of SREBP1/SCD1-mediated lipid metabolism boosts hepatosteatosis and cancer
In this study, we demonstrated that high-fat diet potentiated mouse liver AKT2. Hepatic AKT2 hyperactivation through gain-of-function mutation of Akt2 (Akt2E17K) caused spontaneous hepatosteatosis, injury, inflammation, fibrosis, and eventually HCC in mice. (Source: Translational Research)
Source: Translational Research - January 18, 2024 Category: Research Authors: Fuqiang Huang, Na Zhao, Pei Cai, Mengjie Hou, Shuhui Yang, Bohao Zheng, Qian Ma, Jingpeng Jiang, Xiaochen Gai, Yilei Mao, Lianmei Wang, Zhongdong Hu, Xiaojun Zha, Fangming Liu, Hongbing Zhang Source Type: research
Interleukin-33/ST2 Axis Involvement in Atrial Remodeling and Arrhythmogenesis
This study explored the pathological effects of the IL-33/ST2 axis on atrial remodeling and arrhythmogenesis. Patch clamping, confocal microscopy, and Western blotting were used to analyze the electrical characteristics of and protein activity in atrial myocytes (HL-1) treated with recombinant IL-33 protein and/or ST2-neutralizing antibodies for 48 hrs. (Source: Translational Research)
Source: Translational Research - January 18, 2024 Category: Research Authors: Tzu- Yu Cheng, Yao-Chang Chen, Shao-Jung Li, Fong-Jhih Lin, Yen-Yu Lu, Ting-I Lee, Ting-Wei Lee, Satoshi Higa, Yu-Hsun Kao, Yi-Jen Chen Source Type: research
