Editorial Advisory Board
(Source: Translational Research)
Source: Translational Research - November 1, 2023 Category: Research Source Type: research
Author Guidelines
(Source: Translational Research)
Source: Translational Research - November 1, 2023 Category: Research Source Type: research
Novel MSH2 and TSC2 variants in a Chinese family with Lynch syndrome and their synergistic impact in urothelial carcinoma
In this study, we present the case of a young patient diagnosed with upper urinary tract urothelial carcinoma, notable for a familial history of diverse malignancies. By employing genetic analysis, we verified the presence of Lynch syndrome within the family and detected novel variants, MSH2 p.A604D and TSC2 p.C738Y, utilizing NGS technology. (Source: Translational Research)
Source: Translational Research - October 30, 2023 Category: Research Authors: Mingyang Li, Xingjian Yan, He Liu, Wenhao Miao, Wenbo Wu, Yuyang Zhao, Chungang Wang, Haitao Liu Source Type: research
Repurposing calcium-sensing receptor activator drug cinacalcet for ADPKD treatment
ADPKD is characterized by progressive cyst formation and enlargement leading to renal failure. Tolvaptan is currently the only FDA-approved treatment for ADPKD; however, it can cause serious adverse effects including hepatotoxicity. There remains an unmet clinical need for effective and safe treatments for ADPKD. The extracellular Ca2+-sensing receptor (CaSR) is a regulator of epithelial ion transport. FDA-approved CaSR activator cinacalcet can reduce cAMP-induced Cl − and fluid secretion in various epithelial cells by activating phosphodiesterases (PDE) that hydrolyze cAMP. (Source: Translational Research)
Source: Translational Research - October 28, 2023 Category: Research Authors: Pattareeya Yottasan, Tifany Chu, Parth D. Chhetri, Onur Cil Source Type: research
Rough neighborhood: Intricacies of cancer stem cells and infiltrating immune cell interaction in tumor microenvironment and potential in therapeutic targeting.
Ongoing research on cellular heterogeneity of Cancer stem cells (CSCs) and its synergistic involvement with tumor milieu reveals enormous complexity, resulting in diverse hindrance in immune therapy. CSCs has captured attention for their contribution in shaping of tumor microenvironment and as target for therapeutic intervention. Recent studies have highlighted cell-extrinsic and intrinsic mechanisms of reciprocal interaction between tumor stroma constituents and CSCs. Therapeutic targeting requires an in-depth understanding of the underlying mechanisms involved with the rate limiting factors in tumor aggressiveness and pi...
Source: Translational Research - October 27, 2023 Category: Research Authors: Krishna Mahanti, Sankar Bhattacharyya Source Type: research
ASH2L-mediated H3K4me3 drives diabetic nephropathy through HIPK2 and Notch1 pathway
Diabetic nephropathy (DN) is one of the complications of diabetes. Long-term hyperglycemia in the kidney results in renal insufficiency, and eventually leads to end-stage renal disease. Epigenetic factor ASH2L has long been identified as a transcriptional activator, and we previously indicated that ASH2L aggravated fibrosis and inflammation in high glucose-induced glomerular mesangial cells, but the pathophysiological relevance and the mechanism of ASH2L-mediated H3K4me3 in DN is not well understood. (Source: Translational Research)
Source: Translational Research - October 23, 2023 Category: Research Authors: Wen Zhong, Chen Hong, Yuyu Zhang, Yuhui Li, Chenxi Xiao, Xinhua Liu Source Type: research
A diagnostic model based on DNA methylation haplotype block characteristics for identifying papillary thyroid carcinoma from thyroid adenoma
In this study, we aimed to develop and validate a diagnostic model for PTC based on DNA methylation markers. A total of 142 thyroid nodule tissue samples containing 84 cases of PTC and 58 cases of thyroid adenoma (TA) were collected for reduced representation bisulfite sequencing (RRBS) and subsequent analysis. (Source: Translational Research)
Source: Translational Research - October 18, 2023 Category: Research Authors: Dong Xu, Yi Lai, Hongmei Liu, He Li, Ningning Feng, Yiying Liu, Chengxiang Gong, Yunzhi Zhang, Jiaqing Zhou, Yuling Shen Source Type: research
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(Source: Translational Research)
Source: Translational Research - September 26, 2023 Category: Research Source Type: research
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(Source: Translational Research)
Source: Translational Research - September 26, 2023 Category: Research Source Type: research
Editorial Advisory Board
(Source: Translational Research)
Source: Translational Research - September 26, 2023 Category: Research Source Type: research
Author Guidelines
(Source: Translational Research)
Source: Translational Research - September 26, 2023 Category: Research Source Type: research
Information for Readers
(Source: Translational Research)
Source: Translational Research - September 26, 2023 Category: Research Source Type: research
Contents
(Source: Translational Research)
Source: Translational Research - September 26, 2023 Category: Research Source Type: research
Inhibition of gasdermin D palmitoylation by disulfiram is crucial for the treatment of myocardial infarction
To investigate the role of S-palmitoylation in pyroptosis following acute myocardial infarction (AMI). (Source: Translational Research)
Source: Translational Research - September 26, 2023 Category: Research Authors: Zehao Zhuang, Jianing Gu, Bo Li, Ling Yang Source Type: research
Dysfunctional Cori and Krebs cycle and inhibition of lactate transporters constitute a mechanism of primary non-function of fatty liver allografts
Orthotopic liver transplantation (OLT) is a lifesaving procedure. However, grafts may fail due to primary non-function (PNF). In the past, we demonstrated PNFs to be mainly associated with fatty allografts, and given its unpredictable nature, the development of a disease model is urgently needed. In an effort to investigate mechanism of fatty-allograft associated PNFs, we induced fatty liver disease in donor animals by feeding rats a diet deficient in methionine and choline (MCD). We performed OLT with allografts of different grades of hepatic steatosis and compared the results to healthy ones. (Source: Translational Research)
Source: Translational Research - September 16, 2023 Category: Research Authors: Ulf Kulik, Caroline Moesta, Reinhard Spanel, J ürgen Borlak Source Type: research
