Establishment of a human 3D pancreatic adenocarcinoma model based on a patient-derived extracellular matrix scaffold
Pancreatic cancer is likely to become one of the leading causes of cancer-related death in many countries within the next decade. Surgery is the potentially curative treatment for pancreatic ductal adenocarcinoma (PDAC), although only 10 –20% of patients have a resectable disease after diagnosis. Despite recent advances in curative surgery the current prognosis ranges from 6 to 10% globally. One of the main issues at the pre-clinical level is the lacking of model which simultaneously reflects the tumour microenvironment (TME) at b oth structural and cellular levels.
Source: Translational Research - Category: Research Authors: Francesca Sensi, Edoardo D'Angelo, Andrea Biccari, Asia Marangio, Giulia Battisti, Sara Crotti, Matteo Fassan, Cecilia Laterza, Monica Giomo, Nicola Elvassore, Gaya Spolverato, Salvatore Pucciarelli, Marco Agostini Source Type: research