Ntsr1 contributes to pulmonary hypertension by enhancing endoplasmic reticulum stress via JAK2-STAT3-Thbs1 signaling
Pulmonary hypertension (PH) is a severe clinical syndrome with pulmonary vascular remodeling and poor long-term prognosis. Neurotensin receptor 1 (Ntsr1), serve as one of the G protein-coupled receptors (GPCRs), implicates in various biological processes, but the potential effects of Ntsr1 in PH development are unclear. The Sugen/Hypoxia (SuHx) or monocrotaline (MCT) induced rat PH model was used in our study and the PH rats showed aggravated pulmonary artery remodeling and increased right ventricular systolic pressure (RVSP).
Source: Translational Research - Category: Research Authors: Zhi-xing Wei, Xing-xing Cai, Yu-dong Fei, Qian wang, Xiao-liang Hu, Cheng Li, Jian-wen Hou, Yu-li Yang, Yue-peng Wang, Yi-Gang Li Source Type: research