Mitochondrial aspartate/glutamate carrier AGC1 regulates cardiac function via Drp1-mediated mitochondrial fission in doxorubicin-induced cardiomyopathy

This study investigated the therapeutic effects of the overexpression of glyoxalase I (GLO1), a detoxifying enzyme of gly cotoxins, on acute hyperglycemia–aggravated ischemic brain injury.  In the present study, adeno-associated viral (AAV)-mediated GLO1 overexpression reduced infarct volume and edema level but did not improve neurofunctional recovery in the mice with middle cerebral artery occlusion (MCAO).

Source: Translational Research - July 5, 2023 Category: Research Authors: Kuan-Jung Lu, Chih-Hao Yang, Joen-Rong Sheu, Chi-Li Chung, Tanasekar Jayakumar, Chieh-Min Chen, Cheng-Ying Hsieh Source Type: research