Overexpressing Glyoxalase 1 Attenuates Acute Hyperglycemia –Exacerbated Neurological Deficits of Ischemic Stroke in Mice

This study investigated the therapeutic effects of the overexpression of glyoxalase 1 (GLO1), a detoxifying enzyme of glycot oxins, on acute hyperglycemia–aggravated ischemic brain injury. In present study, AAV-mediated GLO1 overexpression reduced infarct volume and edema level but did not improve neurofunctional recovery in the mice with MCAO.

https://www.translationalres.com/article/S1931-5244(23)00109-3/fulltext?rss=yes

Source: Translational Research - July 5, 2023 Category: Research Authors: Kuan-Jung Lu, Chih-Hao Yang, Joen-Rong Sheu, Chi-Li Chung, Tanasekar Jayakumar, Chieh-Min Chen, Cheng-Ying Hsieh Source Type: research