Mitochondrial aspartate/glutamate carrier AGC1 regulates cardiac function via Drp1-mediated mitochondrial fission in doxorubicin-induced cardiomyopathy

Mitochondrial fission has been noted in the pathogenesis of dilated cardiomyopathy (DCM), but the underlying specific regulatory mechanism, especially in the development of doxorubicin (DOX)-induced cardiomyopathy remains unclear. In the present study, we explore whether the aspartate-glutamate carrier1 (AGC1) interacts with the fission protein dynamin-related protein 1 (Drp1) and reveal the functional and molecular mechanisms contributing to DOX-induced cardiomyopathy.

Source: Translational Research - July 2, 2023 Category: Research Authors: Yan Xia, Jiayu Jin, Ao Chen, Danbo Lu, Xinyu Che, Jiaqi Ma, Su Li, Ming Yin, Zheng Yang, Hao Lu, Chenguang Li, Jinxiang Chen, Muyin Liu, Yuan Wu, Hui Gong, Yunzeng Zou, Zhangwei Chen, Juying Qian, Junbo Ge Source Type: research