Translational Research : the journal of laboratory and clinical medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The rare circulating tumour microemboli as a biomarker contributes to predicting early colorectal cancer recurrences after medical treatment
This study evaluated the rare circulating tumour microemboli (CTM) from liquid biopsy individually and together with circulating tumour cells (CTCs) and serum CEA/CA19-9 in a panel, on early prediction of colorectal cancer (CRC) recurrence. Stained CTCs/CTM were detected by a microfluidic chip-based automatic rare-cell imaging platform. ROC, AUC, Kaplan-Meier survival, and Cox proportional hazard models regarding four selected biomarkers were analysed. The relative risk, odds ratio, predictive accuracy, and positive/negative predictive value of biomarkers individually and in combination, to predict CRC recurrence were asse...
Source: Translational Research : the journal of laboratory and clinical medicine - August 9, 2023 Category: Laboratory Medicine Authors: Yun-Jie Hao Lu-Wey Chang Chih-Yung Yang Liang-Chuan Lo Chien-Ping Lin Yuan-Wei Jian Jeng-Kai Jiang Fan-Gang Tseng Source Type: research

Myeloid-derived suppressor cells ameliorate Corneal Alkali Burn through IL-10-dependent anti-inflammatory properties
CONCLUSIONS: MDSCs therapy is a promising therapeutic solution for CAB. MDSCs fulfilled immunoregulatory roles for CAB by IL-10-dependent anti-inflammatory properties.PMID:37543286 | DOI:10.1016/j.trsl.2023.07.006 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - August 5, 2023 Category: Laboratory Medicine Authors: Yichen Xiao Jing Zhong Jiahui Yang Zhenyuan Fu Bowen Wang Lulu Peng Xin Zuo Xuan Zhao Dalian He Jin Yuan Source Type: research

Artificial Intelligence Assisted Repurposing of Lubiprostone Alleviates Tubulointerstitial Fibrosis
In conclusion, the high throughput Proximal tubule-on-chip system shows improved in vivo-like function and indicates the potential utility for renal fibrosis drug screening. Additionally, repurposed Lubiprostone shows an effective potency to treat TIF via inhibiting 3 major profibrotic signaling pathways such as TGFβ/Smad, JAK/STAT, and epithelial-mesenchymal transition (EMT) and restores kidney function.PMID:37541485 | DOI:10.1016/j.trsl.2023.07.010 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - August 4, 2023 Category: Laboratory Medicine Authors: Anupama Samantasinghar Faheem Ahmed Chethikkattuveli Salih Abdul Rahim Kyung Hwan Kim Sejong Kim Kyung Hyun Choi Source Type: research

Plasma protein signatures reflect systemic immunity and allograft function in kidney transplantation
Transl Res. 2023 Jul 26:S1931-5244(23)00125-1. doi: 10.1016/j.trsl.2023.07.007. Online ahead of print.ABSTRACTKidney transplantation causes large perturbations of the immune system. While many studies focus on the allograft, insights into systemic effects are largely missing. Here, we analyzed the systemic immune response in 3 cohorts of kidney transplanted patients. Using serum proteomics, laboratory values, mass cytometry, histological and clinical parameters, inter-patient heterogeneity was leveraged for multi-omic co-variation analysis. We identified circulating immune modules (CIM) that describe extra-renal signatures...
Source: Translational Research : the journal of laboratory and clinical medicine - July 28, 2023 Category: Laboratory Medicine Authors: Konrad Buscher Rebecca Rixen Paula Sch ütz Birte H üchtmann Veerle Vanmarck Barbara Heitplatz Ulrich Jehn Daniela A Braun Gert Gabriels Hermann Pavenst ädt Stefan Reuter Source Type: research

Dual-regulation by Cx32 in hepatocyte to trigger and worsen liver graft injury
This study aimed to investigate the role of connexin32 (Cx32) in liver graft injury and elucidate its mechanism of action. Through detecting liver graft samples from 6 patients, we observed that changes in the Cx32 level coincided with liver graft injury. Therefore, we established autologous orthotopic liver transplantation (AOLT) models using Cx32-knockout and wild-type mice and hypoxia/reoxygenation (H/R) and lipopolysaccharide (LPS) pretreatment models using alpha mouse liver 12 (AML12) cells, to explore Cx32 mechanisms in liver graft injury. Following in vivo and in vitro Cx32 knockout, oxidative stress and inflammator...
Source: Translational Research : the journal of laboratory and clinical medicine - July 28, 2023 Category: Laboratory Medicine Authors: Fei Huang Zhizhao Deng Qian Zhang Zheng Zhang Xianlong Li Weiqi Zeng Yanling Wang Ziqing Hei Dongdong Yuan Source Type: research

Plasma protein signatures reflect systemic immunity and allograft function in kidney transplantation
Transl Res. 2023 Jul 26:S1931-5244(23)00125-1. doi: 10.1016/j.trsl.2023.07.007. Online ahead of print.NO ABSTRACTPMID:37507006 | DOI:10.1016/j.trsl.2023.07.007 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - July 28, 2023 Category: Laboratory Medicine Authors: Konrad Buscher Rebecca Rixen Paula Sch ütz Birte H üchtmann Veerle van Marck Barbara Heitplatz Ulrich Jehn Daniela A Braun Gert Gabriels Hermann Pavenst ädt Stefan Reuter Source Type: research