Translational Research : the journal of laboratory and clinical medicine 
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This study aimed to explore the molecular mechanism of lipid metabolic regulation in kidney, especially renal PTECs, and elucidate the role of lipid metabolic related molecule lipin-1 in diabetic lipid-related kidney damage. In this study, lipin-1-deficient db/db mouse model and STZ/HFD-induced T2DM mouse model were used to determine the effect of lipin-1 on DKD development. Then RPTCs and LPIN1 knockdown or overexpressed HK-2 cells induced by PA were used to investigate the mechanism. We found that the expression of lipin-1 increased early and then decreased in kidney during the progression of DKD. Glucose and lipid metab...
Source: Translational Research : the journal of laboratory and clinical medicine - July 11, 2023 Category: Laboratory Medicine Authors: Simei Lin Liang Wang Yingli Jia Ying Sun Panshuang Qiao Yazhu Quan Jihan Liu Huihui Hu Baoxue Yang Hong Zhou Source Type: research
Lipin-1 deficiency deteriorates defect of fatty acid β-oxidation and lipid-related kidney damage in diabetic kidney disease
This study aimed to explore the molecular mechanism of lipid metabolic regulation in kidney, especially renal PTECs, and elucidate the role of lipid metabolic related molecule lipin-1 in diabetic lipid-related kidney damage. In this study, lipin-1-deficient db/db mouse model and STZ/HFD-induced T2DM mouse model were used to determine the effect of lipin-1 on DKD development. Then RPTCs and LPIN1 knockdown or overexpressed HK-2 cells induced by PA were used to investigate the mechanism. We found that the expression of lipin-1 increased early and then decreased in kidney during the progression of DKD. Glucose and lipid metab...
Source: Translational Research : the journal of laboratory and clinical medicine - July 11, 2023 Category: Laboratory Medicine Authors: Simei Lin Liang Wang Yingli Jia Ying Sun Panshuang Qiao Yazhu Quan Jihan Liu Huihui Hu Baoxue Yang Hong Zhou Source Type: research
Lipin-1 deficiency deteriorates defect of fatty acid β-oxidation and lipid-related kidney damage in diabetic kidney disease
This study aimed to explore the molecular mechanism of lipid metabolic regulation in kidney, especially renal PTECs, and elucidate the role of lipid metabolic related molecule lipin-1 in diabetic lipid-related kidney damage. In this study, lipin-1-deficient db/db mouse model and STZ/HFD-induced T2DM mouse model were used to determine the effect of lipin-1 on DKD development. Then RPTCs and LPIN1 knockdown or overexpressed HK-2 cells induced by PA were used to investigate the mechanism. We found that the expression of lipin-1 increased early and then decreased in kidney during the progression of DKD. Glucose and lipid metab...
Source: Translational Research : the journal of laboratory and clinical medicine - July 11, 2023 Category: Laboratory Medicine Authors: Simei Lin Liang Wang Yingli Jia Ying Sun Panshuang Qiao Yazhu Quan Jihan Liu Huihui Hu Baoxue Yang Hong Zhou Source Type: research
Lipin-1 deficiency deteriorates defect of fatty acid β-oxidation and lipid-related kidney damage in diabetic kidney disease
This study aimed to explore the molecular mechanism of lipid metabolic regulation in kidney, especially renal PTECs, and elucidate the role of lipid metabolic related molecule lipin-1 in diabetic lipid-related kidney damage. In this study, lipin-1-deficient db/db mouse model and STZ/HFD-induced T2DM mouse model were used to determine the effect of lipin-1 on DKD development. Then RPTCs and LPIN1 knockdown or overexpressed HK-2 cells induced by PA were used to investigate the mechanism. We found that the expression of lipin-1 increased early and then decreased in kidney during the progression of DKD. Glucose and lipid metab...
Source: Translational Research : the journal of laboratory and clinical medicine - July 11, 2023 Category: Laboratory Medicine Authors: Simei Lin Liang Wang Yingli Jia Ying Sun Panshuang Qiao Yazhu Quan Jihan Liu Huihui Hu Baoxue Yang Hong Zhou Source Type: research
N-acetylcysteine combined with insulin attenuates myocardial injury in canines with type 1 diabetes mellitus by modulating TNF- α-mediated apoptotic pathways and affecting linear ubiquitination
This study aims to explore the therapeutic effect and mechanism of N-acetylcysteine (NAC) combined with insulin on type 1 DM. By giving beagle canines injections of streptozotocin (STZ) and alloxan (ALX) (20 mg/kg each), a model of type 1 DM was created. The results showed that this combination could effectively control blood sugar level, improve heart function, avoid the damage of mitochondria and myocardial cells, and prevent the excessive apoptosis of myocardial cells. Importantly, the combination can activate nuclear factor kappa-B (NF-κB) by promoting linear ubiquitination of receptor-interacting protein kinase 1 (RI...
Source: Translational Research : the journal of laboratory and clinical medicine - July 8, 2023 Category: Laboratory Medicine Authors: Jianjia Huang Xiaoyue Pang Xinting Zhang Wenyue Qiu Xuluan Zhang Rongmei Wang Wenting Xie Yuman Bai Shuilian Zhou Jianzhao Liao Zhaojun Xiong Zhaoxin Tang Rongsheng Su Source Type: research
N-acetylcysteine combined with insulin attenuates myocardial injury in canines with type 1 diabetes mellitus by modulating TNF- α-mediated apoptotic pathways and affecting linear ubiquitination
This study aims to explore the therapeutic effect and mechanism of N-acetylcysteine (NAC) combined with insulin on type 1 DM. By giving beagle canines injections of streptozotocin (STZ) and alloxan (ALX) (20 mg/kg each), a model of type 1 DM was created. The results showed that this combination could effectively control blood sugar level, improve heart function, avoid the damage of mitochondria and myocardial cells, and prevent the excessive apoptosis of myocardial cells. Importantly, the combination can activate nuclear factor kappa-B (NF-κB) by promoting linear ubiquitination of receptor-interacting protein kinase 1 (RI...
Source: Translational Research : the journal of laboratory and clinical medicine - July 8, 2023 Category: Laboratory Medicine Authors: Jianjia Huang Xiaoyue Pang Xinting Zhang Wenyue Qiu Xuluan Zhang Rongmei Wang Wenting Xie Yuman Bai Shuilian Zhou Jianzhao Liao Zhaojun Xiong Zhaoxin Tang Rongsheng Su Source Type: research
N-acetylcysteine combined with insulin attenuates myocardial injury in canines with type 1 diabetes mellitus by modulating TNF- α-mediated apoptotic pathways and affecting linear ubiquitination
This study aims to explore the therapeutic effect and mechanism of N-acetylcysteine (NAC) combined with insulin on type 1 DM. By giving beagle canines injections of streptozotocin (STZ) and alloxan (ALX) (20 mg/kg each), a model of type 1 DM was created. The results showed that this combination could effectively control blood sugar level, improve heart function, avoid the damage of mitochondria and myocardial cells, and prevent the excessive apoptosis of myocardial cells. Importantly, the combination can activate nuclear factor kappa-B (NF-κB) by promoting linear ubiquitination of receptor-interacting protein kinase 1 (RI...
Source: Translational Research : the journal of laboratory and clinical medicine - July 8, 2023 Category: Laboratory Medicine Authors: Jianjia Huang Xiaoyue Pang Xinting Zhang Wenyue Qiu Xuluan Zhang Rongmei Wang Wenting Xie Yuman Bai Shuilian Zhou Jianzhao Liao Zhaojun Xiong Zhaoxin Tang Rongsheng Su Source Type: research
N-acetylcysteine combined with insulin attenuates myocardial injury in canines with type 1 diabetes mellitus by modulating TNF- α-mediated apoptotic pathways and affecting linear ubiquitination
This study aims to explore the therapeutic effect and mechanism of N-acetylcysteine (NAC) combined with insulin on type 1 DM. By giving beagle canines injections of streptozotocin (STZ) and alloxan (ALX) (20 mg/kg each), a model of type 1 DM was created. The results showed that this combination could effectively control blood sugar level, improve heart function, avoid the damage of mitochondria and myocardial cells, and prevent the excessive apoptosis of myocardial cells. Importantly, the combination can activate nuclear factor kappa-B (NF-κB) by promoting linear ubiquitination of receptor-interacting protein kinase 1 (RI...
Source: Translational Research : the journal of laboratory and clinical medicine - July 8, 2023 Category: Laboratory Medicine Authors: Jianjia Huang Xiaoyue Pang Xinting Zhang Wenyue Qiu Xuluan Zhang Rongmei Wang Wenting Xie Yuman Bai Shuilian Zhou Jianzhao Liao Zhaojun Xiong Zhaoxin Tang Rongsheng Su Source Type: research
Depleted Hexokinase1 and lack of AMPK α activation favor OXPHOS-dependent energetics in Retinoblastoma tumors
In this study, we demonstrate that loss of Hexokinase 1(HK1) in tumor cells rewires their metabolism allowing enhanced oxidative phosphorylation-dependent energy production. We show that rescuing HK1 or RB1 in these retinoblastoma cells reduced cancer hallmarks such as proliferation, invasion, spheroid formation and increased their sensitivity to chemotherapy drugs. Induction of HK1 was accompanied by a metabolic shift of the cells to glycolysis and a reduction in mitochondrial mass. Cytoplasmic HK1 bound Liver Kinase B1 (LKB1) and phosphorylated AMP-activated kinase-α (AMPKα Thr172), thereby reducing mitochondria-depend...
Source: Translational Research : the journal of laboratory and clinical medicine - July 7, 2023 Category: Laboratory Medicine Authors: Vishnu Suresh Babu Ashwin Mallipatna Gagan Dudeja Rohit Shetty Archana Padmanabhan Nair Sai Bo Bo Tun Candice Ee Hua Ho Shyam S Chaurasia Shomi S Bhattacharya Navin Kumar Verma Rajamani Lakshminarayanan Nilanjan Guha Stephane Heymans Veluchamy Amutha Bara Source Type: research
Overexpressing Glyoxalase 1 Attenuates Acute Hyperglycemia-Exacerbated Neurological Deficits of Ischemic Stroke in Mice
This study investigated the therapeutic effects of the overexpression of glyoxalase 1 (GLO1), a detoxifying enzyme of glycotoxins, on acute hyperglycemia-aggravated ischemic brain injury. In present study, AAV-mediated GLO1 overexpression reduced infarct volume and edema level but did not improve neurofunctional recovery in the mice with MCAO. AAV-GLO1 infection significantly enhanced neurofunctional recovery in the MCAO mice with acute hyperglycemia but not in the mice with normoglycemia. MG-modified proteins expression significantly increased in the ipsilateral cortex of the MCAO mice with acute hyperglycemia. AAV-GLO1 i...
Source: Translational Research : the journal of laboratory and clinical medicine - July 7, 2023 Category: Laboratory Medicine Authors: Kuan-Jung Lu Chih-Hao Yang Joen-Rong Sheu Chi-Li Chung Tanasekar Jayakumar Chieh-Min Chen Cheng-Ying Hsieh Source Type: research
Mitochondrial aspartate/glutamate carrier AGC1 regulates cardiac function via Drp1-mediated mitochondrial fission in doxorubicin-induced cardiomyopathy
CONCLUSIONS: In summary, our data illustrate that AGC1, as a novel contributor to DCM, regulates cardiac function via Drp1-mediated mitochondrial fission, indicating that targeting AGC1-Drp1 axis could be a potential therapeutic strategy for DOX-induced cardiomyopathy.PMID:37402419 | DOI:10.1016/j.trsl.2023.06.004 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - July 4, 2023 Category: Laboratory Medicine Authors: Yan Xia Jiayu Jin Ao Chen Danbo Lu Xinyu Che Jiaqi Ma Su Li Ming Yin Zheng Yang Hao Lu Chenguang Li Jinxiang Chen Muyin Liu Yuan Wu Hui Gong Yunzeng Zou Zhangwei Chen Juying Qian Junbo Ge Source Type: research
Mitochondrial aspartate/glutamate carrier AGC1 regulates cardiac function via Drp1-mediated mitochondrial fission in doxorubicin-induced cardiomyopathy
CONCLUSIONS: In summary, our data illustrate that AGC1, as a novel contributor to DCM, regulates cardiac function via Drp1-mediated mitochondrial fission, indicating that targeting AGC1-Drp1 axis could be a potential therapeutic strategy for DOX-induced cardiomyopathy.PMID:37402419 | DOI:10.1016/j.trsl.2023.06.004 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - July 4, 2023 Category: Laboratory Medicine Authors: Yan Xia Jiayu Jin Ao Chen Danbo Lu Xinyu Che Jiaqi Ma Su Li Ming Yin Zheng Yang Hao Lu Chenguang Li Jinxiang Chen Muyin Liu Yuan Wu Hui Gong Yunzeng Zou Zhangwei Chen Juying Qian Junbo Ge Source Type: research
Mitochondrial aspartate/glutamate carrier AGC1 regulates cardiac function via Drp1-mediated mitochondrial fission in doxorubicin-induced cardiomyopathy
CONCLUSIONS: In summary, our data illustrate that AGC1, as a novel contributor to DCM, regulates cardiac function via Drp1-mediated mitochondrial fission, indicating that targeting AGC1-Drp1 axis could be a potential therapeutic strategy for DOX-induced cardiomyopathy.PMID:37402419 | DOI:10.1016/j.trsl.2023.06.004 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - July 4, 2023 Category: Laboratory Medicine Authors: Yan Xia Jiayu Jin Ao Chen Danbo Lu Xinyu Che Jiaqi Ma Su Li Ming Yin Zheng Yang Hao Lu Chenguang Li Jinxiang Chen Muyin Liu Yuan Wu Hui Gong Yunzeng Zou Zhangwei Chen Juying Qian Junbo Ge Source Type: research
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer
Transl Res. 2023 Jun 21:S1931-5244(23)00106-8. doi: 10.1016/j.trsl.2023.05.007. Online ahead of print.ABSTRACTHead and neck cancers, which include oral squamous cell carcinoma (OSCC) as a major subsite, exhibit cellular plasticity that includes features of an epithelial-mesenchymal transition (EMT), referred to as partial-EMT (p-EMT). To identify molecular mechanisms contributing to OSCC plasticity, we performed a multiphase analysis of single cell RNA sequencing (scRNAseq) data from human OSCC. This included a multiresolution characterization of cancer cell subgroups to identify pathways and cell states that are heterogen...
Source: Translational Research : the journal of laboratory and clinical medicine - June 23, 2023 Category: Laboratory Medicine Authors: Eric R Reed Stacy A Jankowski Anthony J Spinella Vikki Noonan Robert Haddad Kenichi Nomoto Junji Matsui Manish V Bais Xaralabos Varelas Maria A Kukuruzinska Stefano Monti Source Type: research
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer
Transl Res. 2023 Jun 21:S1931-5244(23)00106-8. doi: 10.1016/j.trsl.2023.05.007. Online ahead of print.ABSTRACTHead and neck cancers, which include oral squamous cell carcinoma (OSCC) as a major subsite, exhibit cellular plasticity that includes features of an epithelial-mesenchymal transition (EMT), referred to as partial-EMT (p-EMT). To identify molecular mechanisms contributing to OSCC plasticity, we performed a multiphase analysis of single cell RNA sequencing (scRNAseq) data from human OSCC. This included a multiresolution characterization of cancer cell subgroups to identify pathways and cell states that are heterogen...
Source: Translational Research : the journal of laboratory and clinical medicine - June 23, 2023 Category: Laboratory Medicine Authors: Eric R Reed Stacy A Jankowski Anthony J Spinella Vikki Noonan Robert Haddad Kenichi Nomoto Junji Matsui Manish V Bais Xaralabos Varelas Maria A Kukuruzinska Stefano Monti Source Type: research
