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ASH2L-mediated H3K4me3 drives diabetic nephropathy through HIPK2 and Notch1 pathway
Transl Res. 2023 Oct 23:S1931-5244(23)00160-3. doi: 10.1016/j.trsl.2023.10.002. Online ahead of print.ABSTRACTDiabetic nephropathy (DN) is one of the complications of diabetes. Long-term hyperglycemia in the kidney results in renal insufficiency, and eventually leads to end-stage renal disease. Epigenetic factor ASH2L has long been identified as a transcriptional activator, and we previously indicated that ASH2L aggravated fibrosis and inflammation in high glucose-induced glomerular mesangial cells, but the pathophysiological relevance and the mechanism of ASH2L-mediated H3K4me3 in DN is not well understood. Here we demons...
Source: Translational Research : the journal of laboratory and clinical medicine - October 25, 2023 Category: Laboratory Medicine Authors: Wen Zhong Chen Hong Yuyu Zhang Yuhui Li Chenxi Xiao Xinhua Liu Source Type: research

A diagnostic model based on DNA methylation haplotype block characteristics for identifying papillary thyroid carcinoma from thyroid adenoma
In this study, we aimed to develop and validate a diagnostic model for PTC based on DNA methylation markers. A total of 142 thyroid nodule tissue samples containing 84 cases of PTC and 58 cases of thyroid adenoma (TA) were collected for reduced representation bisulfite sequencing (RRBS) and subsequent analysis. The diagnostic model was constructed by the logistic regression (LR) method followed by 5-cross validation and based on 94 tissue methylation haplotype block (MHB) markers. The model achieved an area under the receiver operating characteristic curve (AUROC) of 0.974 (95% CI, 0.964-0.981) on 108 training samples and ...
Source: Translational Research : the journal of laboratory and clinical medicine - October 20, 2023 Category: Laboratory Medicine Authors: Dong Xu Yi Lai Hongmei Liu He Li Ningning Feng Yiying Liu Chengxiang Gong Yunzhi Zhang Jiaqing Zhou Yuling Shen Source Type: research

Inhibition of gasdermin D palmitoylation by disulfiram is crucial for the treatment of myocardial infarction
Transl Res. 2023 Sep 27:S1931-5244(23)00158-5. doi: 10.1016/j.trsl.2023.09.007. Online ahead of print.ABSTRACTTo investigate the role of S-palmitoylation in pyroptosis following acute myocardial infarction (AMI). Myocardial ischemic injury is mainly related to the death of terminally differentiated cardiomyocytes. Pyroptosis is a new form of programmed cell death and recently is identified a potential mechanism of cardiomyocyte loss. However, the role of S-palmitoylation in pyroptosis following MI remains elusive. AMI was mimicked by permanent left anterior descending artery ligation. The palmitoylated proteins labeled by ...
Source: Translational Research : the journal of laboratory and clinical medicine - September 28, 2023 Category: Laboratory Medicine Authors: Zehao Zhuang Jianing Gu B O Li Ling Yang Source Type: research

Inhibition of gasdermin D palmitoylation by disulfiram is crucial for the treatment of myocardial infarction
CONCLUSIONS: We identifies ZHDDC14 induced palmitoylation as a crucial node for modulating GSDMD-N-terminal cytomembrane localization and establishes Disulfiram targeting GSDMD Cys192 palmitoylation as a potential clinical intervention for myocardial pyroptosis.PMID:37769810 | DOI:10.1016/j.trsl.2023.09.007 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - September 28, 2023 Category: Laboratory Medicine Authors: Zehao Zhuang Jianing Gu Bo Li Ling Yang Source Type: research