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Multi-dimensional metabolomic profiling reveals dysregulated ornithine metabolism hallmarks associated with a severe acute pancreatitis phenotype
CONCLUSIONS: The plasma metabolome of AP patients is distinctive, which shows promise for early SAP diagnosis. AP aggravation is linked to the activated ornithine metabolic pathway and its inadequate levels of catabolites in in-situ lesion.PMID:37619665 | DOI:10.1016/j.trsl.2023.08.003 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - August 24, 2023 Category: Laboratory Medicine Authors: Jinxi Yang Na Shi Shisheng Wang Manjiangcuo Wang Yan Huang Yiqin Wang Ge Liang Juqin Yang Juan Rong Yun Ma Lan Li Ping Zhu Chenxia Han Tao Jin Hao Yang Wei Huang Daniel Raftery Qing Xia Dan Du Source Type: research

Transcription factor EBF1 mitigates neuropathic pain by rescuing Kv1.2 expression in primary sensory neurons
In this study, we examined whether early B cell factor 1 (EBF1), a transcription factor, in the DRG participated in neuropathic pain caused by chronic constriction injury (CCI) of the sciatic nerve. EBF1 was distributed exclusively in neuronal nucleus and co-expressed with cytoplasmic/membrane Kv1.2 in individual DRG neurons. The expression of Ebf1 mRNA and protein was time-dependently downregulated in the ipsilateral lumbar (L) 3/4 DRGs after unilateral CCI. Rescuing this downregulation through microinjection of the adeno-associated virus 5 expressing full-length Ebf1 mRNA into the ipsilateral L3/4 DRGs reversed the CCI-i...
Source: Translational Research : the journal of laboratory and clinical medicine - August 22, 2023 Category: Laboratory Medicine Authors: Yingping Liang Dilip Sharma Bing Wang Huixing Wang Xiaozhou Feng Ruining Ma Tolga Berkman Steven Char Alex Bekker Yuan-Xiang Tao Source Type: research

Extensive therapeutic effects, underlying molecular mechanisms and disease treatment prediction of Metformin: a systematic review
Transl Res. 2023 Aug 9:S1931-5244(23)00130-5. doi: 10.1016/j.trsl.2023.08.001. Online ahead of print.ABSTRACTMetformin, a first-line management for Type 2 Diabetes Mellitus, has been expansively employed and studied with results indicating its therapeutic potential extending beyond glycaemic control. Beyond its established role, this therapeutic drug demonstrates a broad spectrum of action encompassing over sixty disorders, encompassing metabolic conditions, inflammatory disorders, carcinomas, cardiovascular diseases, and cerebrovascular pathologies. There is clear evidence of metformin's action targeting specific nodes in...
Source: Translational Research : the journal of laboratory and clinical medicine - August 11, 2023 Category: Laboratory Medicine Authors: Yifei Geng Zhen Wang Xiaoyu Xu Xiao Sun Xi Dong Yun Luo Xiaobo Sun Source Type: research

The rare circulating tumour microemboli as a biomarker contributes to predicting early colorectal cancer recurrences after medical treatment
This study evaluated the rare circulating tumour microemboli (CTM) from liquid biopsy individually and together with circulating tumour cells (CTCs) and serum CEA/CA19-9 in a panel, on early prediction of colorectal cancer (CRC) recurrence. Stained CTCs/CTM were detected by a microfluidic chip-based automatic rare-cell imaging platform. ROC, AUC, Kaplan-Meier survival, and Cox proportional hazard models regarding four selected biomarkers were analysed. The relative risk, odds ratio, predictive accuracy, and positive/negative predictive value of biomarkers individually and in combination, to predict CRC recurrence were asse...
Source: Translational Research : the journal of laboratory and clinical medicine - August 9, 2023 Category: Laboratory Medicine Authors: Yun-Jie Hao Lu-Wey Chang Chih-Yung Yang Liang-Chuan Lo Chien-Ping Lin Yuan-Wei Jian Jeng-Kai Jiang Fan-Gang Tseng Source Type: research