Translational Research : the journal of laboratory and clinical medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Endothelial ELABELA improves post-ischemic angiogenesis by upregulating VEGFR2 expression
CONCLUSION: Our results indicated that endothelial ELA is a positive regulator of post-ischemic angiogenesis via upregulating VEGFR2 expression. Targeting ELA may be a potential therapeutic option for peripheral arterial diseases.PMID:38548174 | DOI:10.1016/j.trsl.2024.03.011 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - March 28, 2024 Category: Laboratory Medicine Authors: Jia-Yu Peng Xiao Fu Xue-Yang Luo Fang Liu Bing Zhang Bin Zhou Kun Sun Alex F Chen Source Type: research

The LPS-inactivating enzyme acyloxyacyl hydrolase protects the brain from experimental stroke
Transl Res. 2024 Mar 22:S1931-5244(24)00052-5. doi: 10.1016/j.trsl.2024.03.007. Online ahead of print.ABSTRACTBlood-brain-barrier (BBB) disruption is a pathological hallmark of ischemic stroke, and inflammation occurring at the BBB contributes to the pathogenesis of ischemic brain injury. Lipopolysaccharide (LPS), a cell wall component of Gram-negative bacteria, is elevated in patients with acute stroke. The activity of LPS is controlled by acyloxyacyl hydrolase (AOAH), a host enzyme that deacylates LPS to inactivated forms. However, whether AOAH influences the pathogenesis of ischemic stroke remain elusive. We performed i...
Source: Translational Research : the journal of laboratory and clinical medicine - March 24, 2024 Category: Laboratory Medicine Authors: Yuanbo Zhu Yue Hu Zhongwang Liu Luping Chang Xue Geng Xuhui Yin Bing-Qiao Zhao Wenying Fan Source Type: research

Reversal of cisplatin resistance in oral squamous cell carcinoma by piperlongumine loaded smart nanoparticles through inhibition of Hippo-YAP signaling pathway
Transl Res. 2024 Mar 16:S1931-5244(24)00049-5. doi: 10.1016/j.trsl.2024.03.004. Online ahead of print.ABSTRACTCisplatin alone or in combination with 5FU and docetaxel is the preferred chemotherapy regimen for advanced-stage OSCC patients. However, its use has been linked to recurrence and metastasis due to the development of drug resistance. Therefore, sensitization of cancer cells to conventional chemotherapeutics can be an effective strategy to overcome drug resistance. Piperlongumine, an alkaloid, have shown anticancer properties and sensitizes numerous neoplasms, but its effect on OSCC has not been explored. However, l...
Source: Translational Research : the journal of laboratory and clinical medicine - March 18, 2024 Category: Laboratory Medicine Authors: Pratikshya Sa Priya Singh Sudhakar Panda Rajeeb K Swain Rupesh Dash Sanjeeb Kumar Sahoo Source Type: research

Genetic and pharmacological targeting of XBP1 alleviates hepatic ischemia reperfusion injury by enhancing FoxO1-dependent mitophagy
In conclusion, the inhibition of XBP1 potentiated FoxO1-mediated mitophagy in hepatic I/R injury. Specific genetic and pharmacological treatment targeting XBP1 in the perioperative 6 h prior to reperfusion exerted beneficial effects, thus providing a novel therapeutic approach.PMID:38494125 | DOI:10.1016/j.trsl.2024.03.006 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - March 17, 2024 Category: Laboratory Medicine Authors: Baicheng Kuang Mengqin Wang Hao Yan Qin Jiang Zhiheng Wang Haiqiang Ni Shuaiheng Hou Xuan Peng Shiqi Gu Yuanyuan Zhao Tongwen Ou Nianqiao Gong Source Type: research

The pregnancy-associated protein glycodelin as a potential sex-specific target for resistance to immunotherapy in non-small cell lung cancer
Transl Res. 2024 Mar 13:S1931-5244(24)00036-7. doi: 10.1016/j.trsl.2024.02.007. Online ahead of print.ABSTRACTLung cancer has been shown to be targetable by novel immunotherapies which reactivate the immune system and enable tumor cell killing. However, treatment failure and resistance to these therapies is common. Consideration of sex as a factor influencing therapy resistance is still rare. We hypothesize that the success of the treatment is impaired by the presence of the immunosuppressive pregnancy-associated glycoprotein glycodelin that is expressed in patients with non-small-cell lung cancer (NSCLC). We demonstrate t...
Source: Translational Research : the journal of laboratory and clinical medicine - March 15, 2024 Category: Laboratory Medicine Authors: Sarah Richtmann Sebastian Marwitz Thomas Muley Hannu Koistinen Petros Christopoulos Michael Thomas Daniel Kazdal Michael Allg äuer Hauke Winter Torsten Goldmann Michael Meister Ursula Klingm üller Marc A Schneider Source Type: research

PCSK9 inhibition protects mice from food allergy
Transl Res. 2024 Mar 10:S1931-5244(24)00048-3. doi: 10.1016/j.trsl.2024.03.001. Online ahead of print.ABSTRACTThe Proprotein Convertase Subtilisin Kexin of type 9 (PCSK9) has been identified in 2003 as the third gene involved in familial hypercholesterolemia. PCSK9 binds to the membrane low-density lipoprotein receptor (LDLR) and promotes its cellular internalization and lysosomal degradation. Beyond this canonical role, PCSK9 was recently described to be involved in several immune responses. However, to date, the contribution of PCSK9 in food allergy remains unknown. Here, we showed that Pcsk9 deficiency or pharmacologica...
Source: Translational Research : the journal of laboratory and clinical medicine - March 12, 2024 Category: Laboratory Medicine Authors: Victoria Lorant Martin Klein Damien Gar çon Thibaud Sotin Samuel Frey Marie-Aude Cheminant Audrey Ayer Mika ël Croyal Laurent Flet Antoine Rimbert Luc Colas Bertrand Cariou Gr égory Bouchaud C édric Le May Source Type: research