Translational Research : the journal of laboratory and clinical medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Adenosinergic metabolism pathway: an emerging target for improving outcomes of solid organ transplantation
Transl Res. 2023 Sep 5:S1931-5244(23)00142-1. doi: 10.1016/j.trsl.2023.09.002. Online ahead of print.ABSTRACTExtracellular nucleotides are widely recognized as crucial modulators of immune responses in peripheral tissues. ATP and adenosine are key components of extracellular nucleotides, the balance of which contributes to immune homeostasis. Under tissue injury, ATP exerts its pro-inflammatory function, while the adenosinergic pathway rapidly degrades ATP to immunosuppressive adenosine, thus inhibiting excessive and uncontrolled inflammatory responses. Previous reviews have explored the immunoregulatory role of extracellu...
Source: Translational Research : the journal of laboratory and clinical medicine - September 7, 2023 Category: Laboratory Medicine Authors: Bingran Wang Aiwei Zhou Qi Pan Yanran Li Zhifeng Xi Kang He Dan Li Bin Li Yongbo Liu Yuan Liu Qiang Xia Source Type: research

Employing the sustained-release properties of poly(lactic-co-glycolic acid) nanoparticles to reveal a novel mechanism of sodium-hydrogen exchanger 1 in neuropathic pain
Transl Res. 2023 Sep 5:S1931-5244(23)00143-3. doi: 10.1016/j.trsl.2023.09.003. Online ahead of print.ABSTRACTNeuropathic pain is caused by injury or disease of the somatosensory system, and its course is usually chronic. Several studies have been dedicated to investigating neuropathic pain-related targets; however, little attention has been paid to the persistent alterations that these targets, some of which may be crucial to the pathophysiology of neuropathic pain. The present study aimed to identify potential targets that may play a crucial role in neuropathic pain and validate their long-term impact. Through bioinformat...
Source: Translational Research : the journal of laboratory and clinical medicine - September 7, 2023 Category: Laboratory Medicine Authors: Junhua Wu Meiling Jin Quangdon Tran Minwoo Kim Song I Kim Juhee Shin Hyewon Park Nara Shin Hyunji Kang Hyo Jung Shin Sun Yeul Lee Song-Biao Cui C Justin Lee Won Hyung Lee Dong Woon Kim Source Type: research

Calcium-sensing receptor activator cinacalcet for treatment of cyclic nucleotide-mediated secretory diarrheas
CONCLUSIONS: Our findings suggest that CaSR activator cinacalcet has antidiarrheal efficacy in distinct human cell, organoid and mouse models of secretory diarrhea. Considering its excellent clinical safety profile, cinacalcet can be repurposed as a treatment for secretory diarrheas including cholera.PMID:37678755 | DOI:10.1016/j.trsl.2023.09.001 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - September 7, 2023 Category: Laboratory Medicine Authors: Tifany Chu Pattareeya Yottasan Livia de Souza Goncalves Apurva A Oak Ruxian Lin Ming Tse Mark Donowitz Onur Cil Source Type: research

Multi-dimensional metabolomic profiling reveals dysregulated ornithine metabolism hallmarks associated with a severe acute pancreatitis phenotype
CONCLUSIONS: The plasma metabolome of AP patients is distinctive, which shows promise for early SAP diagnosis. AP aggravation is linked to the activated ornithine metabolic pathway and its inadequate levels of catabolites in in-situ lesion.PMID:37619665 | DOI:10.1016/j.trsl.2023.08.003 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - August 24, 2023 Category: Laboratory Medicine Authors: Jinxi Yang Na Shi Shisheng Wang Manjiangcuo Wang Yan Huang Yiqin Wang Ge Liang Juqin Yang Juan Rong Yun Ma Lan Li Ping Zhu Chenxia Han Tao Jin Hao Yang Wei Huang Daniel Raftery Qing Xia Dan Du Source Type: research