Translational Research : the journal of laboratory and clinical medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Transcriptomic profiling of sciatic nerves and dorsal root ganglia reveals site-specific effects of prediabetic neuropathy
Transl Res. 2024 Mar 29;270:24-41. doi: 10.1016/j.trsl.2024.03.009. Online ahead of print.ABSTRACTPeripheral neuropathy (PN) is a severe and frequent complication of obesity, prediabetes, and type 2 diabetes characterized by progressive distal-to-proximal peripheral nerve degeneration. However, a comprehensive understanding of the mechanisms underlying PN, and whether these mechanisms change during PN progression, is currently lacking. Here, gene expression data were obtained from distal (sciatic nerve; SCN) and proximal (dorsal root ganglia; DRG) injury sites of a high-fat diet (HFD)-induced mouse model of obesity/prediab...
Source: Translational Research : the journal of laboratory and clinical medicine - March 31, 2024 Category: Laboratory Medicine Authors: St éphanie A Eid Sarah E Elzinga Kai Guo Lucy M Hinder John M Hayes Crystal M Pacut Emily J Koubek Junguk Hur Eva L Feldman Source Type: research

Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury
Transl Res. 2024 Mar 29;270:1-12. doi: 10.1016/j.trsl.2024.03.005. Online ahead of print.ABSTRACTThe prevalence of renal ischemia/reperfusion injury (IRI) in premenopausal women is considerably lower than that in age-matched men. This suggests that sex-related differences in mitochondrial function and homeostasis may contribute to sexual dimorphism in renal injury, though the mechanism remains unclear. Mouse model of unilateral left renal IRI with contralateral kidney enucleation, Ovariectomy in female mice, and a human embryonic kidney (HEK) cell model of hypoxia-reoxygenation were used to study how estrogen affects the s...
Source: Translational Research : the journal of laboratory and clinical medicine - March 31, 2024 Category: Laboratory Medicine Authors: Hanlin Yao Hongchao Zhao Yang Du Ye Zhang Yanze Li Hengcheng Zhu Source Type: research

Transcriptomic profiling of sciatic nerves and dorsal root ganglia reveals site-specific effects of prediabetic neuropathy
Transl Res. 2024 Mar 29:S1931-5244(24)00060-4. doi: 10.1016/j.trsl.2024.03.009. Online ahead of print.ABSTRACTPeripheral neuropathy (PN) is a severe and frequent complication of obesity, prediabetes, and type 2 diabetes characterized by progressive distal-to-proximal peripheral nerve degeneration. However, a comprehensive understanding of the mechanisms underlying PN, and whether these mechanisms change during PN progression, is currently lacking. Here, gene expression data were obtained from distal (sciatic nerve; SCN) and proximal (dorsal root ganglia; DRG) injury sites of a high-fat diet (HFD)-induced mouse model of obe...
Source: Translational Research : the journal of laboratory and clinical medicine - March 31, 2024 Category: Laboratory Medicine Authors: St éphanie A Eid Sarah E Elzinga Kai Guo Lucy M Hinder John M Hayes Crystal M Pacut Emily J Koubek Junguk Hur Eva L Feldman Source Type: research

Sex-Related Differences in SIRT3-Mediated Mitochondrial Dynamics in Renal Ischemia/Reperfusion Injury
Transl Res. 2024 Mar 29:S1931-5244(24)00050-1. doi: 10.1016/j.trsl.2024.03.005. Online ahead of print.ABSTRACTThe prevalence of renal ischemia/reperfusion injury (IRI) in premenopausal women is considerably lower than that in age-matched men. This suggests that sex-related differences in mitochondrial function and homeostasis may contribute to sexual dimorphism in renal injury, though the mechanism remains unclear. Mouse model of unilateral left renal IRI with contralateral kidney enucleation, Ovariectomy in female mice, and a human embryonic kidney (HEK) cell model of hypoxia-reoxygenation were used to study how estrogen ...
Source: Translational Research : the journal of laboratory and clinical medicine - March 31, 2024 Category: Laboratory Medicine Authors: Hanlin Yao Hongchao Zhao Yang Du Ye Zhang Yanze Li Hengcheng Zhu Source Type: research

A transcribed ultraconserved noncoding RNA, uc.285+, promotes colorectal cancer proliferation through dual targeting of CDC42 by directly binding mRNA and protein
Transl Res. 2024 Mar 27:S1931-5244(24)00061-6. doi: 10.1016/j.trsl.2024.03.008. Online ahead of print.ABSTRACTThe transcribed ultraconserved region (T-UCR) belongs to a new type of lncRNAs that are conserved in homologous regions of the rat, mouse and human genomes. A lot of research has reported that differential expression of T-UCRs can influence the development of various cancers, revealing the ability of T-UCRs as new therapeutic targets or potential cancer biomarkers. Most studies on the molecular mechanisms of T-UCRs in cancer have focused on ceRNA regulatory networks and interactions with target proteins, but the pr...
Source: Translational Research : the journal of laboratory and clinical medicine - March 29, 2024 Category: Laboratory Medicine Authors: Sixian Chen Qingyun Zhao Ruirui Zhang Jungang Liu Wenyi Peng Haotian Xu Xiaofei Li Xin Wang Shuilian Wu Gang Li Aruo Nan Source Type: research

Endothelial ELABELA improves post-ischemic angiogenesis by upregulating VEGFR2 expression
CONCLUSION: Our results indicated that endothelial ELA is a positive regulator of post-ischemic angiogenesis via upregulating VEGFR2 expression. Targeting ELA may be a potential therapeutic option for peripheral arterial diseases.PMID:38548174 | DOI:10.1016/j.trsl.2024.03.011 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - March 28, 2024 Category: Laboratory Medicine Authors: Jia-Yu Peng Xiao Fu Xue-Yang Luo Fang Liu Bing Zhang Bin Zhou Kun Sun Alex F Chen Source Type: research