Translational Research : the journal of laboratory and clinical medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Inhibition of G protein-coupled receptor 68 using homoharringtonine attenuates chronic kidney disease-associated cardiac impairment
Transl Res. 2024 Feb 22:S1931-5244(24)00032-X. doi: 10.1016/j.trsl.2024.02.004. Online ahead of print.ABSTRACTChronic kidney disease (CKD) induces cardiac inflammation and fibrosis and reduces survival. We previously demonstrated that G protein-coupled receptor 68 (GPR68) promotes cardiac inflammation and fibrosis in mice with 5/6 nephrectomy (5/6Nx) and patients with CKD. However, no method of GPR68 inhibition has been found that has potential for therapeutic application. Here, we report that Cephalotaxus harringtonia var. nana extract and homoharringtonine ameliorate cardiac inflammation and fibrosis under CKD by suppres...
Source: Translational Research : the journal of laboratory and clinical medicine - February 24, 2024 Category: Laboratory Medicine Authors: Yuya Yoshida Kohei Fukuoka Miyu Sakugawa Masayuki Kurogi Kengo Hamamura Keika Hamasaki Fumiaki Tsurusaki Kurumi Sotono Takumi Nishi Taiki Fukuda Taisei Kumamoto Kosuke Oyama Takashi Ogino Akito Tsuruta Kouta Mayanagi Tomohiro Yamashita Hiroyuki Fuchino No Source Type: research

Characterization of the plasma proteomic profile of Fabry disease: Potential sex- and clinical phenotype-specific biomarkers
Transl Res. 2024 Feb 21:S1931-5244(24)00035-5. doi: 10.1016/j.trsl.2024.02.006. Online ahead of print.ABSTRACTFabry disease (FD) is a X-linked rare lysosomal storage disorder caused by deficient α-galactosidase A (α-GalA) activity. Early diagnosis and the prediction of disease course are complicated by the clinical heterogeneity of FD, as well as by the frequently inconclusive biochemical and genetic test results that do not correlate with clinical course. We sought to identify potential biomarkers of FD to better understand the underlying pathophysiology and clinical phenotypes. We compared the plasma proteomes of 50 FD...
Source: Translational Research : the journal of laboratory and clinical medicine - February 23, 2024 Category: Laboratory Medicine Authors: Laura L ópez-Valverde Mar ía E Vázquez-Mosquera Crist óbal Colón-Mejeras Susana B Bravo Sof ía Barbosa-Gouveia J V íctor Álvarez Rosario S ánchez-Martínez Manuel L ópez-Mendoza M ónica López-Rodríguez Eduardo Villacorta-Arg üelles Mar ía A Source Type: research

Elevated expression of complement factor I in lung cancer cells associates with shorter survival - potentially via non-canonical mechanism
Transl Res. 2024 Feb 21:S1931-5244(24)00033-1. doi: 10.1016/j.trsl.2024.02.003. Online ahead of print.ABSTRACTWhile numerous membrane-bound complement inhibitors protect the body's cells from innate immunity's autoaggression, soluble inhibitors like complement factor I (FI) are rarely produced outside the liver. Previously, we reported the expression of FI in non-small cell lung cancer (NSCLC) cell lines. Now, we assessed the content of FI in cancer biopsies from lung cancer patients and associated the results with clinicopathological characteristics and clinical outcomes. Immunohistochemical staining intensity did not cor...
Source: Translational Research : the journal of laboratory and clinical medicine - February 23, 2024 Category: Laboratory Medicine Authors: Anna Felberg Micha ł Bieńkowski Tomasz Stokowy Kamil Myszczy ński Zuzanna Polakiewicz Kamila Kitowska Rafa ł Sądej Frida Mohlin Alicja Ku źniewska Daria Kowalska Grzegorz Stasi łojć Ilse Jongerius Robbert Spaapen Miguel Mesa-Guzman Luis M Montueng Source Type: research

Ntsr1 contributes to pulmonary hypertension by enhancing endoplasmic reticulum stress via JAK2-STAT3-Thbs1 signaling
Transl Res. 2024 Feb 21:S1931-5244(24)00031-8. doi: 10.1016/j.trsl.2024.02.002. Online ahead of print.ABSTRACTPulmonary hypertension (PH) is a severe clinical syndrome with pulmonary vascular remodeling and poor long-term prognosis. Neurotensin receptor 1 (Ntsr1), serve as one of the G protein-coupled receptors (GPCRs), implicates in various biological processes, but the potential effects of Ntsr1 in PH development are unclear. The Sugen/Hypoxia (SuHx) or monocrotaline (MCT) induced rat PH model was used in our study and the PH rats showed aggravated pulmonary artery remodeling and increased right ventricular systolic pres...
Source: Translational Research : the journal of laboratory and clinical medicine - February 23, 2024 Category: Laboratory Medicine Authors: Zhi-Xing Wei Xing-Xing Cai Yu-Dong Fei Qian Wang Xiao-Liang Hu Cheng Li Jian-Wen Hou Yu-Li Yang Yue-Peng Wang Yi-Gang Li Source Type: research

Nebulized platelet-derived extracellular vesicles attenuate chronic cigarette smoke-induced murine emphysema
In this study, a murine model of CS-induced emphysema was used to determine whether nebulized PEP can influence the development of CS-induced emphysema through the mitigation of oxidative stress and inflammation in the lung. Nebulization of PEP effectively delivered the PEP vesicles into the alveolar region, with evidence of their uptake by type I and type II alveolar epithelial cells and macrophages. Lung function testing and morphometric assessment showed a significant attenuation of CS-induced emphysema in mice treated with nebulized PEP thrice weekly for 4 weeks. Whole lung immuno-oncology RNA sequencing analysis revea...
Source: Translational Research : the journal of laboratory and clinical medicine - February 7, 2024 Category: Laboratory Medicine Authors: Weixia Xuan Shaohua Wang Amarilys Alarcon-Calderon Monique Simone Bagwell Rachel Para Faping Wang Chujie Zhang Xue Tian Paul Stalboerger Timothy Peterson Michael S Sabbah Zeji Du Tiffany Sarrafian Ryan Mahlberg Matthew L Hillestad Skylar A Rizzo Christoph Source Type: research

Nebulized Platelet-Derived Extracellular Vesicles Attenuate Chronic Cigarette Smoke-Induced Murine Emphysema
In this study, a murine model of CS-induced emphysema was used to determine whether nebulized PEP can influence the development of CS-induced emphysema through the mitigation of oxidative stress and inflammation in the lung. Nebulization of PEP effectively delivered the PEP vesicles into the alveolar region, with evidence of their uptake by type I and type II alveolar epithelial cells and macrophages. Lung function testing and morphometric assessment showed a significant attenuation of CS-induced emphysema in mice treated with nebulized PEP thrice weekly for 4 weeks. Whole lung immuno-oncology RNA sequencing analysis revea...
Source: Translational Research : the journal of laboratory and clinical medicine - February 7, 2024 Category: Laboratory Medicine Authors: Weixia Xuan Shaohua Wang Amarilys Alarcon-Calderon Monique Simone Bagwell Rachel Para Faping Wang Chujie Zhang Xue Tian Paul Stalboerger Timothy Peterson Michael Sabbah Zeji Du Tiffany Sarrafian Ryan Mahlberg Matt Hillestad Skylar A Rizzo Chris Paradise A Source Type: research

Targeting a cardiac abundant and fibroblasts-specific piRNA (CFRPi) to attenuate and reverse cardiac fibrosis in pressure-overloaded heart failure
Transl Res. 2024 Feb 1:S1931-5244(24)00013-6. doi: 10.1016/j.trsl.2024.01.003. Online ahead of print.ABSTRACTCardiac fibrosis under chronic pressure overload is an end-stage adverse remodeling of heart. However, current heart failure treatments barely focus on anti-fibrosis and the effects are limited. We aimed to seek for a cardiac abundant and cardiac fibrosis specific piRNA, exploring its underlying mechanism and therapeutic potential. Whole transcriptome sequencing and the following verification experiments identified a highly upregulated piRNA (piRNA-000691) in transverse aortic constriction (TAC) mice, TAC pig, and h...
Source: Translational Research : the journal of laboratory and clinical medicine - February 1, 2024 Category: Laboratory Medicine Authors: Bo Chen Bozhong Shi Zijie Zhou Yue Cui Guowei Zeng Lingyan Cheng Xiaoyang Zhang Kai Luo Cong Li Zhongqun Zhu Zhifang Zhang Jinghao Zheng Xiaomin He Source Type: research

Reducing SULT2B1 promotes the interaction of LncRNAgga3-204 with SMAD4 to inhibit the macrophage inflammatory response and delay atherosclerosis progression
This study aims to investigate the impact of sulfotransferase family 2b member 1 (SULT2B1) on the inflammatory response of macrophages and the progression of AS. Here, we reported that SULT2B1 expression increased with the progression of AS. In AS model mice, knockdown of Sult2b1 led to remission of AS and reduced inflammation levels. Further exploration of the downstream molecular mechanisms of SULT2B1 revealed that suppressing Sult2b1 in macrophages resulted in decreased levels of 25HC3S in the nucleus, elevated expression of Lxr, and increased the transcription of Lncgga3-204. In vivo, knockdown of Lncgga3-204 aggravate...
Source: Translational Research : the journal of laboratory and clinical medicine - January 29, 2024 Category: Laboratory Medicine Authors: Hangyu Pan Tongwei Wu Kang Huang Zhongzhou Guo Hongbin Liang Ping Lyu Hui Huang Xinyi Feng Qianqian Wang Jing Hu Yihua He Zhigang Guo Mengzhuo Yin Yanan Zhang Source Type: research