Translational Research : the journal of laboratory and clinical medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Metadherin orchestrates PKA and PKM2 to activate β-catenin signaling in podocytes during proteinuric chronic kidney disease
Transl Res. 2023 Nov 21:S1931-5244(23)00186-X. doi: 10.1016/j.trsl.2023.11.006. Online ahead of print.ABSTRACTPodocyte damage is the major cause of glomerular injury and proteinuria in multiple chronic kidney diseases. Metadherin (MTDH) is involved in podocyte apoptosis and promotes renal tubular injury in mouse models of diabetic nephropathy and renal fibrosis; however, its role in podocyte injury and proteinuria needs further exploration. Here, we show that MTDH was induced in the glomerular podocytes of patients with proteinuric chronic kidney disease and correlated with proteinuria. Podocyte-specific knockout of MTDH i...
Source: Translational Research : the journal of laboratory and clinical medicine - November 23, 2023 Category: Laboratory Medicine Authors: Xiaowen Chen Jing Xiao Danping Tao Yunyi Liang Sijia Chen Lingyu Shen Shuting Li Zerong Zheng Yao Zeng Congwei Luo Fenfen Peng Haibo Long Source Type: research

Repurposing calcium-sensing receptor activator drug cinacalcet for ADPKD treatment
Transl Res. 2023 Oct 30:S1931-5244(23)00177-9. doi: 10.1016/j.trsl.2023.10.005. Online ahead of print.ABSTRACTADPKD is characterized by progressive cyst formation and enlargement leading to kidney failure. Tolvaptan is currently the only FDA-approved treatment for ADPKD; however, it can cause serious adverse effects including hepatotoxicity. There remains an unmet clinical need for effective and safe treatments for ADPKD. The extracellular Ca2+-sensing receptor (CaSR) is a regulator of epithelial ion transport. FDA-approved CaSR activator cinacalcet can reduce cAMP-induced Cl- and fluid secretion in various epithelial cell...
Source: Translational Research : the journal of laboratory and clinical medicine - November 22, 2023 Category: Laboratory Medicine Authors: Pattareeya Yottasan Tifany Chu Parth D Chhetri Onur Cil Source Type: research

Knockdown of ADAM8 inhibits the proliferation, migration, invasion, and tumorigenesis of renal clear cell carcinoma cells to enhance the immunotherapy efficacy
Transl Res. 2023 Nov 20:S1931-5244(23)00183-4. doi: 10.1016/j.trsl.2023.11.003. Online ahead of print.ABSTRACTThe current study performed bioinformatics and in vitro and in vivo experiments to explore the effects of ADAM8 on the malignant behaviors and immunotherapeutic efficacy of renal clear cell carcinoma (ccRCC) Cells. The modular genes most associated with immune cells were screened. Then, prognostic risk models were constructed by univariate COX analysis, LASSO regression analysis and multivariate COX analysis, and their diagnostic value was determined. The correlation between tumor mutation load (TMB) scores and the...
Source: Translational Research : the journal of laboratory and clinical medicine - November 22, 2023 Category: Laboratory Medicine Authors: Hongchen Qu Minghuan Mao Kai Wang Zhongyi Mu Bin Hu Source Type: research

High Comorbidity of Pediatric Cancers in Patients with Birth Defects: Insights from Whole Genome Sequencing Analysis of Copy Number Variations
CONCLUSIONS: This study revealed that P/LP CNVs were common in a large cohort of BD patients with high rate of pediatric cancers. We present a comprehensive spectrum of P/LP CNVs in patients with BDs and various cancers. Notably, deletions involving E2F target genes and genes implicated in mitotic spindle assembly and G2/M checkpoint were identified, potentially disrupting cell-cycle progression and providing mechanistic insights into the concurrent occurrence of BDs and cancers.PMID:37989391 | DOI:10.1016/j.trsl.2023.11.004 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - November 21, 2023 Category: Laboratory Medicine Authors: Hui-Qi Qu Joseph T Glessner Jingchun Qu Yichuan Liu Deborah Watson Xiao Chang Amir Hossein Saeidian Haijun Qiu Frank D Mentch John J Connolly Hakon Hakonarson Source Type: research

Current updates on metabolites and its interlinked pathways as biomarkers for diabetic kidney disease: a systematic review
Transl Res. 2023 Nov 10:S1931-5244(23)00182-2. doi: 10.1016/j.trsl.2023.11.002. Online ahead of print.ABSTRACTDiabetic kidney disease (DKD) is a major microvascular complication of diabetes mellitus (DM) that poses a serious risk as it can lead to end-stage renal disease (ESRD). DKD is linked to changes in the diversity, composition, and functionality of the microbiota present in the gastrointestinal tract. The interplay between the gut microbiota and the host organism is primarily facilitated by metabolites generated by microbial metabolic processes from both dietary substrates and endogenous host compounds. The productio...
Source: Translational Research : the journal of laboratory and clinical medicine - November 12, 2023 Category: Laboratory Medicine Authors: Soumik Das Devi Rajeswari Ganesh Venkataraman Ramprasad Elumalai Sivaraman Dhanasekaran Gnanasambandan Ramanathan Source Type: research

Tumor molecular landscape of Epstein-Barr virus (EBV) related nasopharyngeal carcinoma in EBV-endemic and non-endemic areas: implications for improving treatment modalities
Transl Res. 2023 Nov 8:S1931-5244(23)00178-0. doi: 10.1016/j.trsl.2023.10.004. Online ahead of print.ABSTRACTEpstein-Barr virus (EBV) related- nasopharyngeal carcinoma (NPC) is a squamous carcinoma of the nasopharyngeal mucosal lining. Endemic areas (EA) are east and Southeast Asia, were NPC was recorded with higher incidence and longer estimated survival than in non-endemic area (NEA) such as Europe, We analyzed the gene expression and microenvironment properties of NPC in both areas to identify molecular subtypes and assess biological and clinical correlates that might explain the differences in incidence and outcome bet...
Source: Translational Research : the journal of laboratory and clinical medicine - November 10, 2023 Category: Laboratory Medicine Authors: Deborah Lenoci Carlo Resteghini Mara S Serafini Federico Pistore Silvana Canevari Brigette Ma Stefano Cavalieri Salvatore Alfieri Annalisa Trama Lisa Licitra Loris De Cecco Source Type: research